COSMOtherm as an Effective Tool for Selection of Deep Eutectic Solvents Based Ready-To-Use Extracts from Graševina Grape Pomace

Abstract

The aim of this work is to develop an industrially suitable process for the sustainable waste disposal in wine production. The proposed process involves the development of an environmentally friendly method for the isolation of biologically active compounds from Graševina grape pomace according to the green extraction principles, in order to obtain a ready-to-use extract. In this process, deep eutectic solvents (DES) were used as extraction solvents. Aiming to save time in selecting the optimal DES that would provide the most efficient Graševina pomace polyphenols extraction, the user-friendly software COSMOtherm was used and 45 DES were screened. Moreover, the prepared extracts were chemically and biologically characterized to confirm their safety for human application. Computational and experimental results proved the applicability of COSMOtherm in the selection of the optimal DES for the environmentally friendly preparation of the ready-to-use extract from Graševina grape pomace with expected application in the cosmetic industry.

Valorization of Wine-Making By-Products’ Extracts in Cosmetics

“…The latter can be used for an environmentally friendly recovery of polyphenols from grape pomaces to be used in subsequent cosmetic applications. This software is expected to save time and reduce the experimental costs of the solvent selection process [48].…”

White Grape Pomace Valorization for Remediating Purposes

“…These can be further purified and valorized. Their second property refers to the capacity of promoting the hydrolysis of the pomace cellular walls for a more accessible release of the nutrients [37], as well as for obtaining eutectic solvents [38] or using as a source of natural antibiotics for the poultry industry [39]. The considered methods have the primary objective of developing sustainable analytic methods and reducing the impact on the ecosystems throughout the circular economy concept.…”

Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.

“…ILs and DES have similar physicochemical properties, but DES are easier and more affordable to synthesize and store [8]. Moreover, DES can be tailored to produce combinations with suitable physicochemical features that allow for the extraction of a specific group of bioactive molecules, for a particular purpose [10].…”

“…In other words, they change their state from solid to liquid when mixed in a proper ratio [11,12]. The hypothesis is that the mixture of the primary metabolites forms an alternative media to water and lipids in the living organisms, which enables the synthesis of poorly water-soluble or insoluble molecules (e.g., rutin, cellulose, and lignin), and biochemical reactions in harsh environmental conditions such as drought, cold, and salt stress [10]. This concept led to the discovery of natural deep eutectic solvents (NADES), a new generation of DES, consisting of a mixture of primary metabolites such as sugars, organic acid, amino acids, and chlorine derivates [3].…”