Ultrasound activatable microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy

Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

“…Liang et al. developed a CuO 2 /TiO 2 heterostructure consisting of CuO 2 nanoclusters and oxygen vacancy-rich porous titanium oxide (OVTiO 2 ) nanosheets, and subsequently incorporated the complex into microneedles to enhance the effects of sono-chemodynamic and thermal antibacterial therapy [ 141 ]. In in vitro experiments, the number of MRSA and P. aeruginosa colonies in the CuO 2 /TiO 2 +US group was reduced by 7.30 and 7.35 orders of magnitude, respectively, after 5 ​min of US radiation (1.0 ​W/cm 2 , 1 ​MHz), with an inhibition rate >99.9999%.…”

“…(H) IL-6 and TNF- α levels in the sera of mice at the end of different treatments. (I) The blood test panel of mice after 12 days of treatment [ 141 ]. Copyright©2022 Acta Materialia Inc.…”

Carbomer Hydrogel Composed of Cu2O and Hematoporphyrin Monomethyl Ether Promotes the Healing of Infected Wounds

“…13 In addition, Cu 2 O nanoparticles triggered by the laser would produce photogenerated electron−hole pairs that would contribute to antibacterial, which is called the hole effect. 14 These character makes it a brilliant choice serving as a carrier of drugs and a basic wound dressing material. In brief, a compound hydrogel system for skin curing was completed.…”

Manganese Dioxide/Gold-based Active Tumor Targeting Nanoprobes for Enhancing Photodynamic and Low-Temperature-Photothermal Combination Therapy in Lung Cancer

“…The design and preparation of multifunctional nanoplatforms with integrated functions have aroused extensive interest among nanobiotechnologists. Recently, an increasing number of diagnostic nanoprobes have been developed based on inorganic, organic, and organic/inorganic nanomaterials for image-guided photodynamic therapy (PTT), photothermal therapy (PDT), and acoustic therapy of cancer. − In addition to these laser or ultrasound-mediated therapies, there are also chemodynamic therapy (CDT) that produce singlet states to kill tumor cells by Fenton or Fenton-like reaction in the presence of H 2 O 2 . , The surface functional groups of these nanomaterials ( e.g. , inorganic materials) are relatively easy to modify, which can be used to encapsulate drugs and are equipped with a variety of imaging/healing properties. − Although they have excellent therapeutic efficacy in animal models, their inherent low biodegradation is a serious obstacle to their clinical use.…”

“…1−5 In addition to these laser or ultrasound-mediated therapies, there are also chemodynamic therapy (CDT) that produce singlet states to kill tumor cells by Fenton or Fenton-like reaction in the presence of H 2 O 2 . 6,7 The surface functional groups of these nanomaterials (e.g., inorganic materials) are relatively easy to modify, which can be used to encapsulate drugs and are equipped with a variety of imaging/ healing properties. 8−10 Although they have excellent therapeutic efficacy in animal models, their inherent low biodegradation is a serious obstacle to their clinical use.…”