Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Xu, Qinglin; Xiu, Weijun; Li, Qiang; Li, Xiaoye; Ding, Meng; Yang, Dongliang; Mou, Yongbin; Dong, Heng

doi:10.1016/j.mtbio.2023.100559

Cited by 31 publications

(17 citation statements)

References 145 publications

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“…In addition, ultrasound-responsive inorganic nanomaterials, especially metallic oxide nanoparticles composed of zinc oxide or titanium dioxide, exhibit excellent efficacy for eradicating microbes. 31 In comparison to light, ultrasound offers significant advantages in terms of tissue penetration and phototoxicity reduction. Particularly, SDT can treat deep-seated lesions beyond the reach of light via targeted delivery and accumulation of SS.…”

Section: Current Strategies For Controlling Infections and Detecting ...mentioning

confidence: 99%

Nano-based theranostic approaches for infection control: current status and perspectives

Huang,

Hu,

et al. 2024

Mater. Chem. Front.

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Section: Current Strategies For Controlling Infections and Detecting ...mentioning

confidence: 99%

Nano-based theranostic approaches for infection control: current status and perspectives

Huang,

Hu,

et al. 2024

Mater. Chem. Front.

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“…A more detailed and comprehensive review of antibiotic treatment, photodynamic therapy, photothermal therapy, sonodynamic therapy, and gas therapy can be seen in these reviews. [ 52,63,64 ] The merits and demerits of different antibacterial methods are briefly summarized in Table 2 . [ 23b,70 ] To date, multimodal antibacterial therapies employing combinations of antibiotic treatment, photodynamic therapy, gas therapy, etc., have been performed.…”

Section: Current Clinical Strategiesmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.

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“…Nanozymes with enzyme-like activity show great potential as antibiofilm nanoagents due to their unique antibacterial mechanism by catalyzing ROS generation. − To date, several nanozymes have been studied to treat implant infections, such as PDA–ferrocene–Nd–Ti plates, MnO 2 –silica diatom microparticles, and CuFe 2 O 4 /GO nanoparticles. − But the low activity of nanozymes to catalyze the generation of ROS often limits their antibacterial activity. , As reported, external stimulation, such as light and US irradiation, can further improve their catalytic activity. − Compared with light irradiation, US irradiation has the advantage of deeper tissue penetration, which facilitates its use in the treatment of implant infections. − …”

Section: Introductionmentioning

confidence: 99%

Self-Adaptive Antibiofilm Effect and Immune Regulation by Hollow Cu₂MoS₄ Nanospheres for Treatment of Implant Infections

Yang

Dong

Xiu

et al. 2023

ACS Appl. Mater. Interfaces

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Implant infections are difficult to cure by traditional antibiotic therapy due to bacterial biofilm-induced antibiotic tolerance and impaired immune responses. To efficiently treat implant infections, therapeutic agents need to kill bacteria and regulate the inflammatory response of immune cells during the biofilm elimination process. Herein, multifunctional smart hollow Cu 2 MoS 4 nanospheres (H-CMS NSs) with pH-responsive enzymelike activities were prepared for self-adaptively eliminating biofilms and regulating the inflammation of macrophages in implant infections. During biofilm infection, the tissue microenvironment around implants is acidic. H-CMS NSs with oxidase (OXD)/ peroxidase (POD)-like activities can catalyze reactive oxidative species (ROS) generation for directly killing bacteria and polarizing macrophages to a proinflammatory phenotype. Moreover, the POD-like activity and antibacterial property of H-CMS NSs can be further enhanced under ultrasound (US) irradiation. After the elimination of biofilms, the tissue microenvironment around implants shifts from acidic to neutral. H-CMS NSs show catalase (CAT)-like activity and eliminate excessive ROS, which polarizes macrophages to anti-inflammatory phenotype and promotes healing of infected tissue. This work provides a smart nanozyme with self-adaptive regulation of the antibiofilm activity and immune response by regulating ROS generation/elimination according to the different pathological microenvironments in implant infections during the different therapeutic stages.

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Cited by 31 publications

References 145 publications

Nano-based theranostic approaches for infection control: current status and perspectives

Nano-based theranostic approaches for infection control: current status and perspectives

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Self-Adaptive Antibiofilm Effect and Immune Regulation by Hollow Cu₂MoS₄ Nanospheres for Treatment of Implant Infections

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Cited by 31 publications

References 145 publications

Nano-based theranostic approaches for infection control: current status and perspectives

Nano-based theranostic approaches for infection control: current status and perspectives

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Self-Adaptive Antibiofilm Effect and Immune Regulation by Hollow Cu2MoS4 Nanospheres for Treatment of Implant Infections

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Product

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Self-Adaptive Antibiofilm Effect and Immune Regulation by Hollow Cu₂MoS₄ Nanospheres for Treatment of Implant Infections