Ultrasonication effect on size distribution of functionalized porous silicon microparticles

Chistè, Elena; Ischia, Gloria; Scarpa, Marina; Daldosso, N.

doi:10.1088/2053-1591/ab1210

Cited by 2 publications

(5 citation statements)

References 29 publications

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“…With these experimental findings, we set up a protocol to get positively charged SPIONs to the pSi-COOH microparticles, whose morphology and porosity have been carefully characterized in previously published works. [14,28] The resulting sample (namely pSi-SPIONs microparticles) was dispersed in PBS.…”

Section: Spions Characterization and Functionalizationmentioning

confidence: 99%

“…[13] To homogenize the microparticles dimension and to reduce and manage their average size, we recently established a simple post-synthesis procedure, based on ultrasounds, without affecting the optical properties. [14] One of the main concerns about the acceptance of this material in theranostics was the fast PL quenching in biological media. To overcome this issue, the pSi microparticles surface has been coated either with organic polymer (e.g., PEG or chitosan) by covalent attachment [15] or with inorganic atomic layer deposition (ALD) of TiO 2 resulting in a shell with tunable thickness.…”

Section: Introductionmentioning

confidence: 99%

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Porous Si Microparticles Infiltrated with Magnetic Nanospheres

et al. 2020

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Porous silicon (pSi) microparticles obtained by porosification of crystalline silicon wafers have unique optical properties that, together with biodegradability, biocompatibility and absence of immunogenicity, are fundamental characteristics to candidate them as tracers in optical imaging techniques and as drug carriers. In this work, we focus on the possibility to track down the pSi microparticles also by MRI (magnetic resonance imaging), thus realizing a comprehensive tool for theranostic applications, i.e., the combination of therapy and diagnostics. We have developed and tested an easy, quick and low-cost protocol to infiltrate the COOH-functionalized pSi microparticles pores (tens of nanometers about) with magnetic nanospheres (SPIONs—Super Paramagnetic Iron Oxide Nanoparticles, about 5–7 nm) and allow an electrostatic interaction. The structural properties and the elemental composition were investigated by electron microscopy techniques coupled to elemental analysis to demonstrate the effective attachment of the SPIONs along the pores’ surface of the pSi microparticles. The magnetic properties were investigated under an external magnetic field to determine the relaxivity properties of the material and resulting in an alteration of the relaxivity of water due to the SPIONs presence, clearly demonstrating the effectiveness of the easy functionalization protocol proposed.

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Section: Spions Characterization and Functionalizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

et al. 2020

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“…For both BM and USF the resulting particles have a range of morphologies and are not spherical. Typical morphologies for pSi particles formed via these techniques can be seen from scanning electron microscopy images, such as those in the following studies [9,12,20]. Depending on the type of comminution process employed, a significant decrease in overall porosity can result.…”

Section: Introductionmentioning

confidence: 99%

“…However, microparticles or nanoparticles are needed for a range of in-vivo applications such as biomedical therapy, which exploit the medical biodegradability and very low toxicity of mesoporous silicon [3]. Different methods are available for converting porous silicon (pSi) films to particles such as mechanical milling [4][5][6] and ultrasonic fragmentation (USF) [7][8][9]. Particle size reduction via milling can be conducted in a dry or wet environment [6], whereas ultrasonic fragmentation utilises liquid immersion of particles.…”

Section: Introductionmentioning

confidence: 99%

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Preserving surface area and porosity during fabrication of silicon aerocrystal particles from anodized wafers

et al. 2020

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Porous silicon layers on wafers are commonly converted into particles by mechanical milling or ultrasonic fragmentation. The former technique can rapidly generate large batches of microparticles. The latter technique is commonly used for making nanoparticles but processing times are very long and yields, where reported, are often very low. With both processing techniques, the porosity and surface area of the particles generated are often assumed to be similar to those of the parent film. We demonstrate that this is rarely the case, using air-dried high porosity and supercritically dried aerocrystals as examples. We show that whereas ball milling can more quickly generate much higher yields of particles, it is much more damaging to the nanostructures than ultrasonic fragmentation. The latter technique is particularly promising for silicon aerocrystals since processing times are reduced whilst yields are simultaneously raised with ultrahigh porosity structures. Not only that, but very high surface areas (> 500 m2/g) can be completely preserved with ultrasonic fragmentation.

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Ultrasonication effect on size distribution of functionalized porous silicon microparticles

Cited by 2 publications

References 29 publications

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Porous Si Microparticles Infiltrated with Magnetic Nanospheres

Preserving surface area and porosity during fabrication of silicon aerocrystal particles from anodized wafers

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