Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Miao, Zhaohua; Jiang, Shanshan; Ding, Mengli; Sun, Siyuan; Ma, Yan; Younis, Muhammad Rizwan; He, Gang; Wang, Jingguo; Lin, Jing; Cao, Zhong; Huang, Peng; Zha, Zhengbao

doi:10.1021/acs.nanolett.9b05035

Cited by 143 publications

(95 citation statements)

References 42 publications

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“…By growing CeO 2 NPs in situ on montmorillonite (MMT) sheets, Zhao et al designed CeO 2 @ MMT nanozymes with SOD-type, CAT-type and • OH scavenging properties to directly target the inflammatory colon for IBD therapy [394]. In this system, MMT alleviated the potential nanotoxicity of CeO 2 NPs via reducing their https://doi.org/10.1007/s40820-021-00674-8 © The authors [396]. On the one hand, Rh-PEG NDs possessed similar RONS removal capacity as natural CAT, thereby alleviating the inflammation of colon disease.…”

Section: Application In Relieving Inflammationmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Application In Relieving Inflammationmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…Nanomaterials with controlled physicochemical properties are useful in the construction of tumor nano vaccines [37] . Moreover, co‐delivering antigens and adjuvants with nanoparticles is an effective method [38] to induce a robust immune response.…”

Section: The Application Of Nanotechnology In Immune Checkpointsmentioning

confidence: 99%

“…Nanomaterials with controlled physicochemical properties are useful in the construction of tumor nano vaccines. [37] Moreover, co-delivering antigens and adjuvants with nanoparticles is an effective method [38] to induce a robust immune response. The increasing leaps in nanotechnology have greatly accelerated the research on nano-vaccine that is easier to synthesize, more biocompatible, [39] and has better therapeutic effects.…”

Section: Nanotechnology Based On Vaccinesmentioning

confidence: 99%

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

Sun

et al. 2020

ChemistrySelect

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Tumor immunotherapy has received worldwide attention in cancer treatment owing to its apparent advantages, such as strong specificity and long curative effect. Among them, significant progress has been made on the immune checkpoint therapy in recent years. FDA approved PD‐L1/PD‐1 and CTLA‐4 immune checkpoint inhibitors have been broadly used in a variety of malignant tumors. However, because of the low response rate of immune checkpoint drugs, its clinical application has been greatly hindered. With the prominence of nanotechnology in bio‐medicine, the application of nanotechnology in immune checkpoints has also gained more and more attention. The combination of radiotherapy, chemotherapy, phototherapy, magnetic therapy and other methods in nanotechnology makes an excellent promoting effect in the treatment of immune checkpoint drugs. This article reviews the recent breakthroughs of nanotechnology in immune checkpoint blocking therapy, mainly focusing on the significant advantages of the combination of nanotechnology‐based immune checkpoint blocking therapy with other treatment methods. In addition, we also discussed the challenges in this area and pointed out some potential directions for future development.

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“…However, the risk of nanotoxicity and the slow elimination of metal nanoparticles seriously limit their clinical application potential. [ 8–11 ] One ideal alternative strategy could be intracellular synthesis of nanoparticles from small molecule precursors (intracellular bottom‐up synthesis, iBuS) in response to tumor‐related stimuli (e.g., pH, redox, or enzyme activity). [ 12–15 ] In this way, the excess precursor molecules could be eliminated by renal clearance, whereas the nanoparticles could be formed and trapped in tumor cells, thus enhancing corresponding therapy.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Bottom‐up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX‐2 Inactivation

Feng

2021

Adv Funct Materials

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The clinical application of photothermal therapy (PTT) is limited by the accuracy of thermal damage and the risk of tumor metastasis and relapse induced by hyperthermia‐related inflammation. Intracellular bottom‐up synthesis (iBuS) of CuS nanoparticles from small‐molecule precursors inside tumor cells triggered by tumor specific stimuli is a promising strategy to enhance the precision of PTT treatment and reduce the risk of nondegradable metal nanoparticles. Herein, monolocking nanoparticles (MLNPs) with Cu‐meloxicam complexes encapsulated by human serum albumin (HSA) are reported, which efficiently form CuS nanodots via the elevated concentration of endogenous H2S inside tumor cells and meanwhile release meloxicam for anti‐inflammatory effects. The intracellular bottom‐up fabrication of CuS nanodots is directly visualized by TEM. An enhanced PTT effect is observed with 4T1 cells caused by additional meloxicam‐induced inactivation of the COX‐2 enzyme. After systemic administration, MLNPs completely ablate tumors under laser exposure, simultaneously inhibiting the inflammation induced by photothermal damage, and can be cleared via the kidney into urine. This strategy provides a new route for activated multimodal therapy, which could be applicable to precisely combat cancer.

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Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Cited by 143 publications

References 42 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Combined Application of Nanotechnology and Multiple Therapies with Tumor Immune Checkpoints

Intracellular Bottom‐up Synthesis of Ultrasmall CuS Nanodots in Cancer Cells for Simultaneous Photothermal Therapy and COX‐2 Inactivation

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