Ultrasensitive electrochemical molecularly imprinted sensor based on AuE/Ag-MOF@MC for determination of hemoglobin using response surface methodology

Multivariate Optimization of Electrochemical Biosensors for the Determination of Compounds Related to Food Safety—A Review

“…As can be seen from the few examples shown, experimental design is widely used for the optimization of electrochemical sensors in many aspects, such as the optimization of electrochemical technique parameters [82][83][84][85], the composition of the surface modifica-tion [86][87][88][89], and accumulation parameters [90][91][92][93], among several other examples. The most common designs used to obtain the response surface in the mentioned examples are Box-Behnken and central composite.…”

Design of a label-free aptasensor for electrochemical determination of hemoglobin: investigation of the peroxidase-like activity of hemoglobin for the sensing of different substrates

“…Most of the Hb-based biosensors reported in the literature suffer from slow rates of direct electron transfer caused by different factors including deep burying of heme groups in the polypeptide chain structure, irreversible denaturation and the lack of the spatial structure that is essential for Hb catalytic behavior. [24][25][26][27] These limitations and others will restrain the direct electron transfer. Therefore, the proposed strategy based on the strongly binding aptamer-target enhances hemoglobin orientation, thus improving the analytical performance of the biosensor.…”

Electrochemical Sensing of Favipiravir with an Innovative Water-Dispersible Molecularly Imprinted Polymer Based on the Bimetallic Metal-Organic Framework: Comparison of Morphological Effects

“…In this context, to overcome these obstacles, metal–organic frameworks have been expanded for the selective recognition of drugs. They have been demonstrated to improve the imprinted efficiency as modifiers in various biochemical and chemical sensors [ 23 , 24 ] because of their high catalytic and electrical properties, high chemical stability, sufficient sensitivity, and good active surface area. The prevailing involvement of MOF composite in a diversity of sensing technologies highlights the necessity for strategies that promote rapid determination and high selectivity in the presence of several interfering agents.…”