Ultrasensitive electrochemical determination of metronidazole based on polydopamine/carboxylic multi-walled carbon nanotubes nanocomposites modified GCE

Abstract

An ultrasensitive electrochemical sensor based on polydopamine/carboxylic multi-walled carbon nanotubes (MWCNTs−COOH) nanocomposites modified glassy carbon electrode (GCE) was presented in this work, which has been developed for highly selective and highly sensitive determination of an antimicrobial drug, metronidazole. The preparation of polydopamine/MWCNTs–COOH nanocomposites/GCE sensor is simple and possesses high reproducible, where polydopamine can be coated on the surface of MWCNTs–COOH via a simple electropolymerization process. Under optimized conditions, the proposed sensor showed ultrasensitive determination for metronidazole with a wide linear detection range from 5 to 5000 µmol/dm3 and a low detection limit of 0.25 µmol/dm3 (S/N = 3). Moreover, the proposed sensor has been successfully applied for the quantitative determination of metronidazole in real drug samples. This work may provide a novel and effective analytical platform for determination of metronidazole in application of real pharmaceutical and biological samples analysis.

Different analytical methods for the determination of metronidazole –A review

“…Life time:1 month. [5] (MNZ) metronidazole based on 1-butyl-3methylimidazolium tetrafluoroborate as (IL) ionic liquid and (SWCNT) single walled carbon nanotube. Using IL in the paste, as a binder, increased the electrode response.…”

Polydopamine‐modified MWCNTs‐glassy Carbon Electrode, a Selective Electrochemical Morphine Sensor

“…In the following, the polydopamine was coated on the surface of the f‐MWCNTs@GCE electrode using electropolymerization method. For this purpose, cyclic voltammetry method was used in 10.0 mM dopamine solution for 10 cycles and a potential window of −0.40–0.70 at a scan rate of 50 mV/s [6].…”

“…Today, due to their fast response, electrochemical methods with suitable sensitivity and selectivity, simplicity, low cost, and low detection limit [5] are widely used in biological sample analysis. Accordingly, numerous electrochemical sensors and biosensors have been devised for pharmaceutical, agricultural, environmental, and food analysis [6]. Sensing layer composition modification for specific interaction with an analyte is crucial for successfully developing voltammetric methods.…”

The theoretical description for the electrochemical determination of 4-4´-dihydroxyazobenzene, assisted by a composite of squaraine dye with cobalt (iii) oxyhydroxide in pair with cobalt (iv) oxide

“…Both redox pair may be applied to the phenolic compounds. Its electroanalytical behavior has been analyzed by either experimental [19][20][21][22] or theoretical [23][24][25][26] means.…”