Ultrasensitive detection of bioanalytes based on signal amplification of coil-integrated giant magnetoimpedance biosystems

Guo, Lei; Zhi, Shaotao; Sun, Xuecheng; Lei, Chong; Zhou, Yong

doi:10.1016/j.snb.2017.01.095

Cited by 21 publications

(7 citation statements)

References 24 publications

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“…Until now, much effort has been made in the development of a nextgeneration bioanalytical system incorporating magnetosensors. Numerous magnetic sensors, such as magneto-resistive sensors, 16,17 magnetic impedance, 18 hall sensors, 19,20 spinvalves 21 and superconducting quantum interference devices 22 have been reported as biosensors for biomagnetic eld detection.…”

Section: Introductionmentioning

confidence: 99%

Sensitive detection of cardiac troponin T based on superparamagnetic bead-labels using a flexible micro-fluxgate sensor

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Sensitive detection of cardiac troponin T based on superparamagnetic bead-labels using a flexible micro-fluxgate sensor

et al. 2017

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“…Magnetic biosensors based on detecting stray magnetic fields induced by immunomagnetic paricles have generated considerable research interest due to the potential for the development of high-performance bioanalyte assay systems. In addition to a low detection limit, a sensing system based on magnetosensors with magnetic bead-labels and sandwich immunoassays is easily manipulated, with a fast response time, and are miniaturized [ 18 – 21 ] when compared to other immunosensing techniques. This makes the technique a viable potential candidate for the rapid analysis of biomolecules and especially for point-of-care platforms.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies focused on developing a new generation of compact bioanalytical systems by incorporating magnetosensors. A number of magnetic biosensors including magneto-resistive sensors [ 18 ], spin-valves [ 19 ], hall sensors [ 20 ], giant magneto-impedance sensors [ 21 ], and superconducting quantum interference devices (SQUIDS) [ 22 ] have been proposed as biosensors for biomagnetic measurements.…”

Section: Introductionmentioning

confidence: 99%

A sensitive and innovative detection method for rapid C-reactive proteins analysis based on a micro-fluxgate sensor system

et al. 2018

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A sensitive and innovative assay system based on a micro-MEMS-fluxgate sensor and immunomagnetic beads-labels was developed for the rapid analysis of C-reactive proteins (CRP). The fluxgate sensor presented in this study was fabricated through standard micro-electro-mechanical system technology. A multi-loop magnetic core made of Fe-based amorphous ribbon was employed as the sensing element, and 3-D solenoid copper coils were used to control the sensing core. Antibody-conjugated immunomagnetic microbeads were strategically utilized as signal tags to label the CRP via the specific conjugation of CRP to polyclonal CRP antibodies. Separate Au film substrates were applied as immunoplatforms to immobilize CRP-beads labels through classical sandwich assays. Detection and quantification of the CRP at different concentrations were implemented by detecting the stray field of CRP labeled magnetic beads using the newly-developed micro-fluxgate sensor. The resulting system exhibited the required sensitivity, stability, reproducibility, and selectivity. A detection limit as low as 0.002 μg/mL CRP with a linearity range from 0.002 μg/mL to 10 μg/mL was achieved, and this suggested that the proposed biosystem possesses high sensitivity. In addition to the extremely low detection limit, the proposed method can be easily manipulated and possesses a quick response time. The response time of our sensor was less than 5 s, and the entire detection period for CRP analysis can be completed in less than 30 min using the current method. Given the detection performance and other advantages such as miniaturization, excellent stability and specificity, the proposed biosensor can be considered as a potential candidate for the rapid analysis of CRP, especially for point-of-care platforms.

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“…They are made by the rotating-water spinning-method and have 10 mm in diameter, high permeability and almost zero magnetostriction coefficient. Guo et al employed a coil-integrated giant magneto-impedance (GMI) biosensor to improve the magnetization level of magnetic particles [ 12 ]. The proposed giant magneto-impedance (GMI) biosensor is composed of symmetrical meandering Ni 77 Fe 23 /Cu/Ni 77 Fe 23 sensing elements for biomagnetic measurement and with an integrated-3D-solenoid coil for signal amplification.…”

Section: Introductionmentioning

confidence: 99%

Improving the Electrical Contact Performance for Amorphous Wire Magnetic Sensor by Employing MEMS Process

Chen

et al. 2018

Micromachines

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This paper presents a novel fabrication method for amorphous alloy wire giant magneto-impedance (GMI) magnetic sensor based on micro electro mechanical systems (MEMS) technology. In this process, negative SU-8 thick photoresist was proposed as the solder mask due to its excellent properties, such as good stability, mechanical properties, etc. The low melting temperature solder paste was used for the electrical connections with the amorphous alloy wire and the electrode pads. Compared with the conventional welding fabrication methods, the proposed micro electro mechanical systems (MEMS) process in this paper showed the advantages of good impedance consistency, and can be fabricated at a low temperature of 150 °C. The amorphous alloy wire magnetic sensor made by the conventional method and by the micro electro mechanical systems (MEMS) process were tested and compared, respectively. The minimum resistance value of the magnetic sensor made by the conventional welding method is 19.8 Ω and the maximum is 28.1 Ω. The variance of the resistance is 7.559 Ω2. The minimum resistance value of the magnetic sensor made by micro electro mechanical systems (MEMS) process is 20.1 Ω and the maximum is 20.5 Ω. The variance of the resistance is 0.029 Ω2. The test results show that the impedance consistency by micro electro mechanical systems (MEMS) process is better than that of the conventional method. The sensor sensitivity is around 150 mV/Oe and the nonlinearity is less than 0.92% F.S.

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Ultrasensitive detection of bioanalytes based on signal amplification of coil-integrated giant magnetoimpedance biosystems

Cited by 21 publications

References 24 publications

Sensitive detection of cardiac troponin T based on superparamagnetic bead-labels using a flexible micro-fluxgate sensor

Sensitive detection of cardiac troponin T based on superparamagnetic bead-labels using a flexible micro-fluxgate sensor

A sensitive and innovative detection method for rapid C-reactive proteins analysis based on a micro-fluxgate sensor system

Improving the Electrical Contact Performance for Amorphous Wire Magnetic Sensor by Employing MEMS Process

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