Ultra-thin liquid film extraction based on a gas–liquid–liquid double emulsion in a microchannel device

Wang, Kai; Kang, Qin; Wang, Tao; Luo, Guangsheng

doi:10.1039/c4ra14489a

Cited by 25 publications

(24 citation statements)

References 29 publications

(30 reference statements)

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“…The three‐phase microflows are effective platforms for the studies in various fields, including biology, chemistry, materials, and engineering . Early in 2005, a protein crystallization process in a glass capillary was successfully demonstrated by Zheng and Ismagilov, where the gas/liquid/liquid three‐phase flow in microchannel was first reported and inert gas slugs were used to prevent droplet coalescence.…”

Section: Introductionmentioning

confidence: 99%

Gas/liquid/liquid three‐phase flow patterns and bubble/droplet size laws in a double T‐junction microchannel

et al. 2015

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The double T‐junction microchannel is a classical microstructured chemical device used to generate gas/liquid/liquid three‐phase microflows. An experimental study that focused on the three‐phase flow phenomena and bubble/droplet generation rules in a double T‐junction microchannel was introduced. Based on the published knowledge of gas/liquid and liquid/liquid two‐phase microflows, new flow patterns were carefully defined: bubble cutting flow, spontaneous break‐up and bubble cutting coupling flow, and bubble/droplet alternate break‐up flow. According to the classical correlations of bubble and droplet volumes and their generation frequency ratio, the operating criteria for creating different three‐phase flow patterns were established and a model for the dimensionless average bubble and droplet volumes in the three‐phase microflows was developed. These various three‐phase microflows have great application potential in material science and flow chemistry synthesis. © 2015 American Institute of Chemical Engineers AIChE J, 61: 1722–1734, 2015

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Section: Introductionmentioning

confidence: 99%

Gas/liquid/liquid three‐phase flow patterns and bubble/droplet size laws in a double T‐junction microchannel

et al. 2015

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“…Double emulsions have enormous potential for a wide range of applications including vesicle preparation, 1 drug delivery, 2 chemical extraction, 3 materials synthesis, [4][5][6][7][8] and the controlled release of encapsulated actives. 9 They can also be analysed in commercial fluorescenceactivated cell sorting (FACS) machines, where the requirement for an aqueous carrier fluid makes the technique incompatible with simple water-in-oil single emulsions with this technique.…”

Section: Introductionmentioning

confidence: 99%

Rapid preparation of highly reliable PDMS double emulsion microfluidic devices

Gong

Nally

et al. 2016

RSC Adv.

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This article presents a simple and highly reliable method for preparing PDMS microfluidic double emulsion devices that employs a single-step oxidative plasma treatment to both pattern the wettability of microchannels and to bond the chips. As a key component of our strategy we use epoxy glue to define the required hydrophobic zones and then remove this after plasma treatment, but prior to bonding. This novel approach achieves surface modification and device sealing in a single process, which reduces chip preparation times to minutes and eliminates the need for unreliable coating processes. The second key element of our procedure is the maintenance of the patterned surfaces, where we demonstrate that immediate filling of the prepared device with water or the use of solventextracted PDMS vastly extends the operational lifetimes of the chips. The reliability of this technique is confirmed by generating water-in-oil-in-water (W/O/W) double emulsion droplets with controlled core/shell structures and volumes, while its versatility is demonstrated by simply using a different placement of the epoxy glue on the same chip design to create oil-in-water-in-oil (O/W/O) double emulsion droplets. Both W/O/W and O/W/O double emulsion droplets can therefore be created from the same soft-lithography mould. This simple method overcomes one of the key problems limiting the wider use of double emulsions lack of reliability while its speed and simplicity will facilitate the high-throughput production of monodisperse double emulsions. Our method is demonstrated to produce double emulsion down to 55 µm in diameter and could be readily extended to produce microfluidic chips with more complex hydrophilic and hydrophobic patterns.

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“…6b), because the double emulsion structure not only enables the direct gas-oil contact, but also largely increased the water-oil interfacial area given a fixed oil volume. In fact, the overall liquid-liquid mass transfer coefficients of the double emulsion structure have been theoretically and experimentally proved to be as much as two orders of magnitude higher than those of the separately dispersed droplets [21,41,43,66]. However, no predominant difference in the extraction efficiency was found between these two dispersion scenarios (Fig.…”

Section: Reaction-extraction Couplingmentioning

confidence: 97%

“…This coupling has the advantages of improving the target product yield (e.g., due to the equilibrium reaction shift to the product side or the suppression of the product degradation in the reactive liquid phase) or simplifying the process workup (e.g., due to the process integration in one flow). Another promising case is in the inert gas assisted liquid-liquid reaction study in microreactors, where the presence of an inert gas (e.g., as discrete bubbles) into an otherwise liquid-liquid flow in microreactors largely increases the extraction and/or reaction efficiency therein [36,39,43], which can lead to a reduced reaction time or solvent use. The synthesis of nanoparticles can also benefit from three-phase flow processing in microreactors.…”

Section: Article Highlightsmentioning

confidence: 99%

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Manipulation of gas-liquid-liquid systems in continuous flow microreactors for efficient reaction processes

2020

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Gas-liquid-liquid flow in microreactors holds great potential towards process intensification of operation in multiphase systems, particularly by a precise control over the three-phase contact patterns and the associated mass transfer enhancement. This work reviews the manipulation of gas-liquid-liquid three-phase flow in microreactors for carrying out efficient reaction processes, including gas-liquid-liquid reactions with catalysts residing in either liquid phase, coupling of a gas-liquid reaction with the liquid-liquid extraction, inert gas assisted liquid-liquid reactions and particle synthesis under three-phase flow. Microreactors are shown to be able to provide well-defined flow patterns and enhanced gas-liquid/liquid-liquid mass transfer rates towards the optimized system performance. The interplay between hydrodynamics and mass transfer, as well as its influence on the overall microreactor system performance is discussed. Meanwhile, future perspectives regarding the scale-up of gas-liquid-liquid microreactors in order to meet the industrial needs and their potential applications especially in biobased chemicals and fuels synthesis are further addressed.

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Ultra-thin liquid film extraction based on a gas–liquid–liquid double emulsion in a microchannel device

Abstract: A gas–liquid–liquid double emulsion with ultra-thin liquid film is proposed for the mass transfer enhancement of an extreme phase ratio system.

Cited by 25 publications

References 29 publications

Gas/liquid/liquid three‐phase flow patterns and bubble/droplet size laws in a double T‐junction microchannel

Gas/liquid/liquid three‐phase flow patterns and bubble/droplet size laws in a double T‐junction microchannel

Rapid preparation of highly reliable PDMS double emulsion microfluidic devices

Manipulation of gas-liquid-liquid systems in continuous flow microreactors for efficient reaction processes

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