Ultra-sensitive detection of bacterial toxin with silicon nanowire transistor

Mishra, Nishikant; Maki, Wusi C.; Cameron, Eric; Nelson, R. O.; Winterrowd, Paul; Rastogi, Shiva K.; Filanoski, Brian; Maki, G.K.

doi:10.1039/b802036a

Cited by 58 publications

(40 citation statements)

References 15 publications

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“…One first explanation could be a transfer of charges (electrons) of the bacteria into the nanowires which fill the traps previously mentioned, and thus could and contribute to the decrease of the electrical resistivity of the nanowires [23]. Another possible reason is that the electrically charged bacteria may behave as biological gate resulting as wellknown field effect [13][14][15]17] on the SiNWs. At last, other explanation is that bacteria may act as additional conducting paths randomly distributed between teeth thanks to hooking effect of bacteria into the SiNWs network.…”

Section: Resultsmentioning

confidence: 99%

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Bacteria electrical detection using 3D silicon nanowires based resistor

Borgne

Pichon

Salaün

et al. 2018

Sensors and Actuators B: Chemical

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Section: Resultsmentioning

confidence: 99%

“…In this case nanowires act as sensing elements. However, few works report on SiNWs use as great promising method for label free, ultra-sensitive and real-time detection of bacteria [17,18].…”

Section: Introductionmentioning

confidence: 99%

Bacteria electrical detection using 3D silicon nanowires based resistor

Borgne

Pichon

Salaün

et al. 2018

Sensors and Actuators B: Chemical

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“…The use of silicon nanowires (SiNW) as the sensitive element of such sensor systems was firstly demonstrated by Lieber and coworkers (15). It has been shown that the devices can be very versatile to detect biomolecules such as DNA (14)(15)(16)(17), proteins (15), antibodies or antigens (18), bacterial toxins (19), virus (20,21), cell secretes (22), cardiac markers (23), and electrical activity of cardiac cells (24)(25)(26) as well as of neurons (27).…”

Section: Introductionmentioning

confidence: 99%

Top-Down Processed SOI Nanowire Devices for Biomedical Applications

Ingebrandt

Eschermann

et al. 2011

ECS Trans.

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We present silicon nanowire (SiNW) devices, which were fabricated in a top-down process from silicon-on-insulator (SOI) substrates with a high yield. Electronic characterization proved reliable electronic properties. Here we report the versatile use of the devices in different applications like label-free sensing of DNA hybridization, electronic detection of cellular signals, and detection of proteins. Compared to micro-sized devices, the SiNWs show an improved sensitivity. Analyses of the electronic cell-nanowire contact showed that the important seal resistance is largely increased, which is a prerequisite for highly-sensitive detection of cellular activity. In all applications the SiNW devices show a reliable performance and are highly interesting for future biomedical products.

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“…Some electrochemical devices which are imunosensors along with cerium oxide nanoparticles and chitosan nanocomposites using nanowire based transistors and carbon nanotubes which detect several toxins like staphylococcal enterotoxin [21] and cholera toxin [22]. These detector systems at nano level have an advantage that they are able to detect impurities, pollutants and toxic chemicals in very low quantity even at nanolevel [23].…”

Section: Detection Of Chemicalsmentioning

confidence: 99%

Nanotechnology and Food. Is Nanotechnology for Food Applications Safe? : A Review

Khan¹

2015

NSTOA

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Nanoscience & Technology: Open AccessOpen Access Review Article nanotechnology arising a new emerging discipline called food nanotechnology. Literally Food and Drug Administration USA (FDA) gives the definition of food nanotechnology in a sense that the nanomaterials used in this case can have size up to 1000 nm because there has been some evidences that even at larger size the particles have same behavior at smaller scale [3].The technology provides its services in almost all sectors of food from production to marketing. In agriculture sector there are several applications available like nano-tech based pesticides and fertilizers with effective impact on plant growth, targeted genetic engineering and molecular farming with the help of nano-vectors which is hoping to take the place of viral vectors [4]. In food processing various industries are also taking leads and making the food with better quality and good nutritive value by utilizing the knowledge of nanotechnology and applying it in food sciences. For example, high impermeable packaging nanomaterials are used for protection of food from UV radiations and providing more strength to keep the food protected from outer environment, thus increasing their shelf life. Beside, nanosensors are also used for the detection of chemicals, gases and pathogens which can represent the spoilage and its rate. In modern terminology a word is given to such type of packaging which is known as smart packaging. Nutritive supplements using polymeric nano-coating with greater bioavailability are also introduced to complete the nutritional requirements. And it is a fact that the most participating research in food nanotechnology is in food processing section in which many researchers and industries are increasing their research in food safety with the help of nanotechnology. Some studies suggested that people are not accepting the direct involvement of nano-particles in food [5] due to some risk factors. So it is needed to provide some safety measurements by creating methods that avoid such direct involvement to reduce the risk and satisfy the community. Organization of Food Structure at Nano-LevelNanoparticles are not always synthetic but nature provide us a view of thinking how these particles are present in nature in various forms as in food, which is a combination of nano versus micro-particles. These molecules make an ordered organization AbstractFood nanotechnology is a combined discipline of food science and nanotechnology. It provides many applications almost in all areas of food technology. This article reviews the main focus in food nanotechnology research of food safety in various forms in which nano-biosensors and antimicrobials nano-agents are the works of interest. These tools are helpful in providing food security and together with nano-coating materials. It makes the base of smart packaging. It is now being estimated from the review that these nanoagents have great contribution in food safety but the health hazard risks due to accumulation of nanomaterials in food s...

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Ultra-sensitive detection of bacterial toxin with silicon nanowire transistor

Cited by 58 publications

References 15 publications

Bacteria electrical detection using 3D silicon nanowires based resistor

Bacteria electrical detection using 3D silicon nanowires based resistor

Top-Down Processed SOI Nanowire Devices for Biomedical Applications

Nanotechnology and Food. Is Nanotechnology for Food Applications Safe? : A Review

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