Ultra-fast cell counters based on microtubular waveguides

Bausch, Cornelius S.; Heyn, Ch.; Hansen, W.; Wolf, Insa M. A.; Diercks, Björn‐Philipp; Guse, Andreas H.; Blick, Robert H.

doi:10.1038/srep41584

Cited by 19 publications

(21 citation statements)

References 22 publications

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“…Swiss‐roll 3D sensors were explored for sensing applications in a microfluidic configuration. For instance, the radial distribution of electric current in the inner channel of the Swiss‐roll architecture allows for the fabrication of highly sensitive impedance based detectors for spectroscopy (Figure c) and tomography applications with sub‐millimeter dimensions . Direct influence of the 3D shape and confinement on biological systems as well as possibilities of cell and tissue manipulation are also investigated using self‐assembled tubular and polygonal shaped structures.…”

Section: Self‐assembled Electronic Devices and Their Shapementioning

confidence: 99%

Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

Karnaushenko

Kang

Schmidt

2019

Adv Materials Technologies

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simple transistors and logics to highly integrated microcontrollers and displays, the latter of which utilizes some of the most technologically advanced processes available in the industry. [3] The success of these technologies has been achieved through enhanced integration of various active functional blocks such as transistors, digital logics, and analog circuits, along with advances in miniaturization and simplification of the overall manufacturing process, eventually leading to large scale, parallel fabrication of silicon chip-based microelectronic components and systems. [4,5] However, many of the manufacturing steps in assembling these electronic components remain either semiparallel or sequential in nature, including processes as dicing, pick and place, packaging, and final assembly of the device. Each additional sequential step increases costs and should ideally be avoided, however substantial streamlining is not always feasible in complex manufacturing processes. [6] More critically, highly integrated silicon-based devices still require several external supporting components for their operation such as wiring, powering, sensing, and communications that cannot be easily integrated within the planar surface of a silicon die. Thus, sensors, actuators, capacitors, coils, antennas, and optics, each crucial for the complete system, are typically placed separately from the silicon chip onto a printed circuit board (PCB), or integrated within another package (Figure 1a). While the need for ever decreasing sizes has demanded tremendous investments and efforts in the manufacture of completed assemblies, the miniaturizing of 3D electronic components (Figure 1b) and systems has nevertheless reached the range of mesoscopic sizes (<1 mm) where the manufacture and assembly of components experience challenges with respect to yield, costs, and reliability. [7] As a result, these issues limit the fabrication potential and commercial viability of components and systems to scales around 1 mm, [8] and despite efforts to improve the planar construction of mesoscopic 3D devices, the results are seen as inefficient and experience difficulties in achieving high performances while maintaining reasonable complexity. Despite the great success in manufacturing active electronics, such concerns are strongly related to the fabrication of passive electronic components like inductors, capacitors, antennas, and resonators where material properties (e.g., mechanical, magnetic, and electrical) and geometry play a crucial role. [8,9] In order to downscale these devices further and improve integration with active electronics, novel fabrication strategies are required.Electronic devices and their components are continually evolving to offer improved performance, smaller sizes, lower weight, and reduced costs, often requiring the state-of-the-art manufacturing and materials to do so. An emerging class of materials and fabrication techniques inspired by self-assembling biological systems shows promise as an alternative to the more traditional m...

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Section: Self‐assembled Electronic Devices and Their Shapementioning

confidence: 99%

Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

Karnaushenko

Kang

Schmidt

2019

Adv Materials Technologies

View full text Add to dashboard Cite

show abstract

“…Also, it can be very challenging if not impossible to probe 3D spatiotemporal activity in‐situ using 2D biosensors. Indeed, as compared to 2D planar geometries, other 3D shapes such as tubular biosensors can show enhanced sensitivity …”

Section: Origami Biosensorsmentioning

confidence: 99%

“…One strategy consists of releasing prestrained bilayers with integrated electrodes that self‐assemble into 3D microstructures with tailored functionalities . With this approach, impedimetric biosensing was used to detect biosamples ranging from HeLa or lymphocyte cells scales down to DNA molecules . The sensing performance of these origami biosensors has been reported to be two to fourfold enhanced as compared to their planar analogs due to higher electric fields and compactness among cells and electrodes imposed by the tubular geometry .…”

Section: Origami Biosensorsmentioning

confidence: 99%

“…With this approach, impedimetric biosensing was used to detect biosamples ranging from HeLa or lymphocyte cells scales down to DNA molecules . The sensing performance of these origami biosensors has been reported to be two to fourfold enhanced as compared to their planar analogs due to higher electric fields and compactness among cells and electrodes imposed by the tubular geometry . It is important to note that the hollow core feature of these tubular geometries is advantageous to couple them with microfluidic components, allowing their use as impedance‐based flow cytometers that are capable to detect single cells in real time and label free .…”

Section: Origami Biosensorsmentioning

confidence: 99%

“…The sensing performance of these origami biosensors has been reported to be two to fourfold enhanced as compared to their planar analogs due to higher electric fields and compactness among cells and electrodes imposed by the tubular geometry . It is important to note that the hollow core feature of these tubular geometries is advantageous to couple them with microfluidic components, allowing their use as impedance‐based flow cytometers that are capable to detect single cells in real time and label free . Ger et al have demonstrated a magnetic origami biosensor self‐assembled by rolling up a magnetic film that actively attracts cells containing diluted magnetite (Fe 3 O 4 ) nanoparticles .…”

Section: Origami Biosensorsmentioning

confidence: 99%

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Origami Biosystems: 3D Assembly Methods for Biomedical Applications

et al. 2018

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Conventional assembly of biosystems has relied on bottom‐up techniques, such as directed aggregation, or top‐down techniques, such as layer‐by‐layer integration, using advanced lithographic and additive manufacturing processes. However, these methods often fail to mimic the complex three dimensional (3D) microstructure of naturally occurring biomachinery, cells, and organisms regarding assembly throughput, precision, material heterogeneity, and resolution. Pop‐up, buckling, and self‐folding methods, reminiscent of paper origami, allow the high‐throughput assembly of static or reconfigurable biosystems of relevance to biosensors, biomicrofluidics, cell and tissue engineering, drug delivery, and minimally invasive surgery. The universal principle in these assembly methods is the engineering of intrinsic or extrinsic forces to cause local or global shape changes via bending, curving, or folding resulting in the final 3D structure. The forces can result from stresses that are engineered either during or applied externally after synthesis or fabrication. The methods facilitate the high‐throughput assembly of biosystems in simultaneously micro or nanopatterned and layered geometries that can be challenging if not impossible to assemble by alternate methods. The authors classify methods based on length scale and biologically relevant applications; examples of significant advances and future challenges are highlighted.

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Microsystems for Single‐Cell Analysis

2017

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Due to the heterogeneity that exists even between cells of the same tissue, it is essential to use techniques and devices able to resolve the characteristics of single biological cells, such as morphology, metabolism, or response to drugs. To that end, different structures with sizes similar to that of individual cells have been developed in recent years, which allow single‐cell studies with high sensitivity and high resolution. By employing a variety of sensing strategies, one can obtain complementary information about individual cells, and thus create a complete picture of cellular properties. This review aims to provide an overview of microscale single‐cell sensors. The progress in micrometer‐sized sensing probes as well as microfluidic and micropatterned devices is described, showing the capabilities of the available systems. In addition, a comprehensive compendium of systems based on rolled‐up microtubes, which have the potential to advance and improve the single‐cell analysis microsystem field, is comprised.

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Ultra-fast cell counters based on microtubular waveguides

Cited by 19 publications

References 22 publications

Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

Shapeable Material Technologies for 3D Self‐Assembly of Mesoscale Electronics

Origami Biosystems: 3D Assembly Methods for Biomedical Applications

Microsystems for Single‐Cell Analysis

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