Úlcera péptica gastroduodenal e infecção pelo Helicobacter pylori na criança e adolescente

Bittencourt, Paulo Fernando Souto; Rocha, Gifone A.; Penna, Francisco José; Queiroz, Dulciene M.

doi:10.1590/s0021-75572006000600004

Cited by 25 publications

(11 citation statements)

References 63 publications

(77 reference statements)

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“…Initial infection with this organism is usually silent but symptoms and pathologic changes occur later in life. The clinical conditions and pathologic changes associated with H. pylori infection include gastritis, gastric and duodenal ulcers, gastric cancers, iron deficiency anaemia and idiopathic thrombocytopenic purpura (ITP) [5–8]. H. pylori infection exhibits a varied geographic distribution on both local and global scales.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa

et al. 2017

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BackgroundHelicobacter pylori infection affects more than half of the world’s population. It is generally acquired during childhood with no symptoms but has long- term clinical sequelae. This study estimated the prevalence of H. pylori infection amongst children in a rural environment in Africa.MethodsWe conducted a cross-sectional study over a four (4)-month period within two rural communities. 240 asymptomatic children were tested using lateral flow immunochromatographic assay for the qualitative detection of H. pylori antigen in a fecal specimen. Statistical analysis and processing was done using Stata version 11.ResultsThe mean age of the participants was 10.5 ± 2.7 years with the predominant age range being 8–10 years (34.6%), and a mean household size of 7.1 ± 1.7. The study population showed a female preponderance of 57.1%. 88% of the H. pylori positive children lacked pipe and borehole drinking water. All of the positive H. pylori children practiced open-air defecation. The overall prevalence of H. pylori infection among children in this study was at least 14.2%.ConclusionOur study demonstrated a high prevalence of H. pylori infection among children in a rural setting. Educational status of parents did not affect H. pylori prevalence but increasing household numbers, female gender, source of drinking water other than pipe and borehole, open-air defecation and younger age were associated with a higher H. pylori prevalence.

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Section: Introductionmentioning

confidence: 99%

Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa

et al. 2017

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“…H. pylori infection is a major health problem in many parts of the world, occurring in 40 - 50% and 80 - 90% of the population in developed and developing countries respectively (2). …”

Section: Introductionmentioning

confidence: 99%

Frequency of sabA Gene in Helicobacter pylori Strains Isolated From Patients in Tehran, Iran

Pakbaz¹,

Shirazi²,

Ranjbar³

et al. 2013

Iran Red Crescent Med J

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Background:The importance of sialic acid binding adhesin (sabA) as a new outer membrane protein in gastroduodenal diseases has been recognized. The prevalence rate of sabA gene varies in different geographic areas. Objectives: The aim of this study was to determine the frequency of sabA gene in Helicobacter pylori (H. pylori) strains isolated from different clinical outcomes in Tehran, Iran. Patients and Methods:The study included 120 patients with dyspeptic symptoms admitted to the endoscopy suite of gastroenterology section of Firouzgar University Hospital, Tehran, Iran from March to August 2011. Gastric biopsy specimens were evaluated for the presence of H. pylori using standard microbiological method and polymerase chain reaction (PCR) assay. The sabA genopositive was determined by PCR in H. pylori strains. Results: H. pylori isolates were recovered from 82 patients with duodenal ulcer (DU; n = 17), gastric ulcer (GU; n = 15), gastric cancer (GC; n = 13), and gastritis (G; n = 37). The frequency of sabA gene in H. pylori strains was 100% in gastric cancer, 86.7% in gastric ulcer, and 83.3% in both gastritis and duodenal ulcer. Conclusions: This is a report on the prevalence of sabA gene in H. pylori isolated from different gastric patients in Iran. The results showed a high prevalence of sabA in our clinical H. pylori isolates.

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“…It is considered the commonest bacterial infection in humans [ 12 , 13 ]. The prevalence of infection varies from age to age, ethnicity and especially socioeconomic status which is an important determinant and inversely correlated with the infection [ 4 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Conservative approaches to this issue suggest that 50% of the population is affected by H. pylori and it is considered the commonest bacterial infection in humans [ 4 ]. Genetic sequencing analysis suggests that humans have been infected with H. pylori since their first migration from Africa some 58,000 years ago [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies

et al. 2017

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BackgroundHelicobacter pylori (H. pylori) infection affects about 50% of the world population and its association with environmental factors and host properties is involved in gastric carcinogenesis. The study aimed to estimate the prevalence of H. pylori in samples of gastric mucosa biopsies, correlate the presence of the bacteria in the sample with the variables age, sex and origin, to identify the types of lesions found in patients with H. pylori, and to evaluate the association of the lesions with the region of the gastric mucosa.MethodsA cross-sectional, retrospective study was carried out in Aracaju, Sergipe, Brazil, from January 2013 to December 2015. A total of 45,206 gastric mucosal biopsies were obtained from patients submitted to upper gastrointestinal endoscopy. Of the reports evaluated, 12,909 met the inclusion criteria since they presented the patient’s demographic data as well as the histopathological characteristics of gastric mucosal regions and positivity for H. pylori. Data were analyzed by IBM SPSS Statistic 20 and subjected to descriptive analyses (categorical variables) and inferential (Pearson’s Qui-square and linear association tests) and multiple correspondence analyses. Significance level adopted 5%.ResultsOf the total of 12,909 (28.6%) reports evaluated, 67% (8,647) came from urban areas and 64.5% (8,320) were female. The mean age (standard deviation (SD)) was 43 years, ranging from 8 to 100 years, prevailing between 21 and 60 years. Among the types of gastric mucosa analyzed, 95.5% (12,322) were of the antral mucosa. The absence of glandular atrophy, the mild infection intensity for H. pylori, the absence of metaplasia, the presence of foveolar hyperplasia and lymphoid follicles were statistically significant (P < 0.001) in this region. In the fundic region, the evidence of fibrinoleucocytic crust and lymphoid follicles was significant (P < 0.001). There was no evidence of associated ulcerated lesions or significant relationship with intestinal metaplasia in the antral mucosa, whereas the fundic mucosa had a strong association with lymphoid follicles. The prevalence of active H. pylori infection in this study was 30.93%.ConclusionDetection rate of H. pylori and its association with acute and chronic inflammation should be taken into account. The antral region has shown higher incidence and the presence of H. pylori was strongly associated with foveolar hyperplasia and lymphoid follicles.

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Úlcera péptica gastroduodenal e infecção pelo Helicobacter pylori na criança e adolescente

Cited by 25 publications

References 63 publications

Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa

Prevalence of helicobacter pylori infection among children living in a rural setting in Sub-Saharan Africa

Frequency of sabA Gene in Helicobacter pylori Strains Isolated From Patients in Tehran, Iran

Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies

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