Frequency of sabA Gene in Helicobacter pylori Strains Isolated From Patients in Tehran, Iran

Abstract

Background:The importance of sialic acid binding adhesin (sabA) as a new outer membrane protein in gastroduodenal diseases has been recognized. The prevalence rate of sabA gene varies in different geographic areas. Objectives: The aim of this study was to determine the frequency of sabA gene in Helicobacter pylori (H. pylori) strains isolated from different clinical outcomes in Tehran, Iran. Patients and Methods:The study included 120 patients with dyspeptic symptoms admitted to the endoscopy suite of gastroenterology section of Firouzgar University Hospital, Tehran, Iran from March to August 2011. Gastric biopsy specimens were evaluated for the presence of H. pylori using standard microbiological method and polymerase chain reaction (PCR) assay. The sabA genopositive was determined by PCR in H. pylori strains. Results: H. pylori isolates were recovered from 82 patients with duodenal ulcer (DU; n = 17), gastric ulcer (GU; n = 15), gastric cancer (GC; n = 13), and gastritis (G; n = 37). The frequency of sabA gene in H. pylori strains was 100% in gastric cancer, 86.7% in gastric ulcer, and 83.3% in both gastritis and duodenal ulcer. Conclusions: This is a report on the prevalence of sabA gene in H. pylori isolated from different gastric patients in Iran. The results showed a high prevalence of sabA in our clinical H. pylori isolates.

Frequency of Helicobacter pylori hopQI, hopQII and sabA Genes Among Iranian Patients with Gastroduodenal Diseases

“…In three previous studies from Iran, the frequency of sabA was reported as 86.6%, 83.6%, and 100%, respectively, with no association with the severity of clinical outcomes (32)(33)(34), and this was in line with the current findings and another study from Japan (29). In comparison with the above-mentioned studies from different countries, the current results showed a considerably lower rate of sabA.…”

Social and Cultural Context Affecting the Activities of Women Painters of Pahlavi Era (1925-1978)

“…(mousavi, 2007) Finally in the year 1940 the fine art faculty was established, which was the first state school at high education level started activity. (Pakbaz, 2002) In respect and by the passage of time the attention to issues and the necessity of action <ministry of education, religious contribution, and fine arts industries>, <beautiful arts general office> and <culture and art ministry> the Pahlavi era changed the art into a planned and possessing a responsible foundation. there were two contrastive tendencies existed during the official art of the Reza Shah art era.…”

“…Eclectic sculpture and architecture-the installment of the stature in urban settings-and attention to the pre-Islamic art era were also in fashion at that time and by the dismissal of the Reza Shah a new era of art was set on. (Pakbaz, 2002) Almost 70 years after the modernism movement in the west its reflections reached Iran and provided a chance for renovation in art areas. So that <open minded people" excitedly were in search of new ways, and their tempted curiosity, moved them towards trying different methods from impressionism to cubism, from surrealist fantasies up to imaginary formation. "…”

Frequency of Helicobacter pylori blood-group antigen-binding adhesion 2 and sialic acid binding adhesion genes among dyspeptic patients in Tabriz, Iran

“…6 SabA binds to carbohydrates and has an important role in initial colonization of H. pylori. 7 Previous studies reported that presence of these factors is associated with the development of gastric cancer, 7 so these molecules influence the severity of inflammation and disease outcome. 8 However, the association between these factors and clinical outcomes has not exactly been determined, and the prevalence of the H. pylori babA2 and sabA genotypes has not yet been determined in Tabriz, Iran.…”

“…6 A study in Tehran, Iran, showed sabA presences in 86.7% with gastric ulcer, and in 83.3% with gastritis and duodenal ulcer. 7 It has been proposed that sabA-positive status is negatively associated with ulcer diseases. We also found that the sabA status was related to clinical outcome in this area and the sabA gene was significantly associated with the presence of non-ulcer diseases (P = 0.005).…”