UJI IRITASI DAN AKTIVITAS PERTUMBUHAN RAMBUT TIKUS PUTIH: EFEK SEDIAAN GEL APIGENIN DAN PERASAN HERBA SELEDRI (Apium graveolens L.)

Kuncari, Emma Sri; Iskandarsyah, Iskandarsyah; Praptiwi,

doi:10.22435/mpk.v25i1.4092.15-22

Cited by 27 publications

(38 citation statements)

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“…Blood flow through the circulatory system will carry adequate nutrition and oxygen supply for hair follicles so that the process of hair growth can occur (Musdalipah and Karmilah, 2018). This is in accordance with research conducted by Kuncari et al (2015) that good hair growth is caused by the stimulation of nutrients received by hair follicles, the maximum process of blood circulation to the hair follicles, and the presence of a substance that can maintain moisture skin that will be overgrown by hair. According to Indriana et al (2018) the process of dilation of blood vessels is known as vasodilation.…”

Section: Resultssupporting

confidence: 72%

“…Compounds such as flavonoids, alkaloids, and saponins can increase the production of the hormone DHT. These compounds act as antioxidants that can strengthen and prevent hair damage (Kuncari et al, 2015). In addition, antioxidants are believed to be able to repair damaged hair cells and produce new cells that will accumulate into active tissue that divides to form a skin condition that is conducive to hair growth (Suhery et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…Substances that trigger the growth of hair length can be raised by activating dormant hair cells, or by repairing oxidative damage that occurs (Kuncari et al, 2015). Besides being influenced by substances found in cayenne pepper leaves, the rate of hair growth is also influenced by the nutritional intake possessed by each test animal (Sari and Adityo, 2016).…”

Section: Resultsmentioning

confidence: 99%

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TOPICAL APPLICATION OF Capsicum frutescens LEAF EXTRACT AS HAIR TONIC IN MICE (Mus musculus)

2020

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The research aims to determine the effect of giving cayenne leaf extract in increasing the length and amount of hair on mice. This research belongs to the type of quantitative research. This research used a Completely Randomized Design (CRD) in consisting of 5 treatment and 4 repetitions. The treatments consisted of NC (negative control, not treated), PC (positive control, given a commercial hair extract), P1 (cayenne leaf extract 10%), P2 (cayenne leaf extract 20%), and P3 (cayenne leaf extract 30%). Research parameters included the increase of the hair length and amount of hairs growing in mice. The result showed that giving extract of cayenne leaf significantly influences the length and amount of hairs in mice, with 10% concentration (P2) was the optimum concentration of the extract that can trigger the hair growth. It can be concluded that given extract of cayenne leaf can increase the hairs growth in mice and has potential as hair tonic.

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Section: Resultssupporting

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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TOPICAL APPLICATION OF Capsicum frutescens LEAF EXTRACT AS HAIR TONIC IN MICE (Mus musculus)

2020

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“…Observation of erythema and edema was carried out at intervals of 24, 48 and 72 hours. Erythema and edema appearing were recorded and scored according to Table 2 (Kuncari et al, 2015). Score that obtained were used to determine the primary irritation index using a formula:…”

Section: Skin Irritation Testmentioning

confidence: 99%

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Lebang¹,

Siampa

Nurmiati

2021

JFG

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Chili pepper leaves have been used empirically as wound healing caused by sharp objects. Several studies show its antibacterial and wound healing activity. This study aims to make gel from chili leaves extract, then to determine its wound healing activity and its irritating properties on rat’s skin. Gel was made using variations type and concentration of gelling agent, consist of carbopol 0.5%, 0.75%, 1% and hydroxypropylmetlcellulose at 2.5%, 5% and 7.5% respectively. Cycling test then conducts to determined its physical stability. Gel that physically stable then evaluated its activity as a wound healer and skin irritation test. Results showed that all formula has no altered on organoleptic properties and pH value. Gel that made from 0.5% carbopol (F2) and 7.5% of HMPC (F5) has no change in spreadability and adhesion properties. Based on statistically analysis using paired t-test and one-way ANOVA, it concludes that F2 and F5 physically stable and could follow wound healer evaluation. Wound healer evaluation show that healing time (days) of carbopol base gel (F2) is 10.2±1.26, HPMC based gel is 8±0.82. Length of incision wound (cm) at the 8th day are 0.5±0.183 for F2 and 0.06±0.071 for F5. Statistically analysis of healing time (p<0.01) and wound length (p<0.05) show that F5 that contain 5% HPMC has significantly different compare to negative control. The results of the irritation test showed that gel formulas not caused erythema and edema on rat’s skin. It can be concluded that gel of chili pepper leave extract that made with 5% of HPMC has wound healing activity and safety to use.

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“…Artinya hand sanitizer kitosan larut air pada semua formulasi yaitu F0, F1, F2, F3, dan F4 tidak melepaskan bahan-bahan kimia yang menyebabkan iritasi terhadap kulit punggung tikus yang berarti produk aman. Hal ini didukung Kuncari et al (2015) bahwa semakin kecil nilai Indeks iritasi pada kulit, maka semakin baik pula sediaan produk yang diujikan. Nilai Indeks iritasi dibawah 0,4 dapat dikatakan sediaan suatu produk aman.…”

Section: Uji Iritasi In Vivo Hand Sanitizerunclassified

Utilization of Water-Soluble Chitosan as Antiseptic Hand Sanitizer

Chamidah

Widiyanti

Fabiyani

2019

JFS

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Shrimp wastes produced by manufacturers are mostly limited to be utilized by small industries. They only can turn the waste into chips and shrimp pastes even though it can be used as chitosan. The scarcity of shrimp waste utilized as chitosan is often constrained due to the lack of chitosan dissolve in water caused by the length of the molecular chain. In order to optimize the chitosan utilization, depolymerization is used; such as using H2O2. Chitosan depolymerization enables chitosan to be water soluble and has a high antibacterial ability, which can be applied as an antiseptic of hand sanitizer which has been derived from synthetic materials. The used method is an experimental method which includes the processing of making water-soluble chitosan with test parameters of deacetylation, solubility, moisture content, and yield. Furthermore, the manufacture of hand sanitizers is carried out in vitro and in vivo. The results showed that water-soluble chitosan can be made at 13% H2O2 concentration at 40°C with deacetylation degree 94.21%, 90% solubility, 10.60% moisture content and 3.5% yield. Moreover, after becoming a hand sanitizer, it was able to inhibit Escherichia coli and Staphylococcus epidermidis bacteria at concentrations of 120 mg/ml, respectively 19.53 mm and 21.12 mm, which were relatively strong. Resulted in MIC values 0.28% and 0.27%, and MBC values 1.12% and 1.08%, and also without causing irritation or edema on mouse skin.

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UJI IRITASI DAN AKTIVITAS PERTUMBUHAN RAMBUT TIKUS PUTIH: EFEK SEDIAAN GEL APIGENIN DAN PERASAN HERBA SELEDRI (Apium graveolens L.)

Cited by 27 publications

References 0 publications

TOPICAL APPLICATION OF Capsicum frutescens LEAF EXTRACT AS HAIR TONIC IN MICE (Mus musculus)

TOPICAL APPLICATION OF Capsicum frutescens LEAF EXTRACT AS HAIR TONIC IN MICE (Mus musculus)

Study of Wound Healing Activity and Skin Irritation of Chili Leaves (Capsicum frutescens L.) Gel in Rats (Rattus novergicus)

Utilization of Water-Soluble Chitosan as Antiseptic Hand Sanitizer

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