UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Baroroh, Faridah; Aznam, Nurfina; Susanti, Hari

doi:10.12928/pharmaciana.v1i1.515

Cited by 7 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Daun kaca piring (Gardenia jasminoides Ellis) dilaporkan dapat sebagai antihiperglikemik. 4 Selain itu, penelitian lainnya menemukan bahwa daun kaca piring memiliki aktivitas antioksidan. 5 Daun kaca piring juga mempunyai aktivitas sebagai antibakteri.…”

Section: Pendahuluanunclassified

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KACA PIRING (Gardenia jasminoides Ellis) TERHADAP TIKUS PUTIH BETINA (Rattus norvegicus L.) GALUR WISTAR

2022

View full text Add to dashboard Cite

Latar belakang. Kaca Piring (Gardenia jasminoides Ellis) telah digunakan sebagai obat tradisional. Daun Kaca Piring secara empiris digununakan untuk pengobatan hipertensi, nyeri pinggang, dan antidiabedes. Penelitian ini bertujuan untuk mengetahui pemberian dosis oral ekstrak etanol daun kaca piring pada dosis tunggal 24 jam terhadap perubahan perilaku, aktivitas psikomotor, perubahan bobot badan, dan indeks organ pada tikus putih betina (Rattus norvegicus L.) galur wistar. Metode. Daun Kaca Piring diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%. Uji toksisitas akut dilakukan berdasarkan pedoman dari OECD (Organization for Economic Co-operation and Development) Nomor 425. Hewan uji terdiri dari kelompok kontrol, dosis 2000 mg/KgBB dan dosis 5000 mg/KgBB. Pengamatan dilakukan selama 14 hari. Perubahan berat badan dan indeks organ dianalisis menggunakan uji one way ANOVA pada perangkat lunak SPSS Versi 25. Hasil. Hasil menunjukkan hewan uji tidak mengalami mortalitas dengan nilai LD50 lebih besar dari 5000 mg/KgBB. Tidak terdapat perbedaan yang signifikan (p>0.05) terhadap berat badan dan indeks organ. Kesimpulan. Ekstrak etanol daun Kaca Piring tidak mempengaruhi parameter toksisitas akut dan termasuk kedalam kategori praktis tidak toksik.

show abstract

Section: Pendahuluanunclassified

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KACA PIRING (Gardenia jasminoides Ellis) TERHADAP TIKUS PUTIH BETINA (Rattus norvegicus L.) GALUR WISTAR

2022

View full text Add to dashboard Cite

show abstract

“…The separated serum was stored at a temperature of 2 −8℃ so that the serum was not damaged. Each solution was then mixed and let it sit for 10 min at 37℃ then the absorbance was read using a spectrophotometer with a wavelength of 500 nm, and the glucose level was calculated using the formula of GOD-PAP method [15].…”

Section: In Vivo Test On Antidiabetic Tablet Effectmentioning

confidence: 99%

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Kurniawan

Yusuf

2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Fig leaves are reported to have an effect on reducing blood glucose levels. However, the use of fresh leaves makes the effects obtained is not measurable and efficient. AIM: The purpose of this research was to determine the antidiabetic potential of ethanol extract of fig leaves and to optimize tablet dosage formulations. METHODS: Four tablet formulas were made using the wet granulation method. Formula I (FI), Formula I (FII), and Formula III (FIII) groups to give a tablet of ethanol extract of fig leaves with a dose of 40 mg, 60 mg, and 80 mg and placebo treatment group. There were eight groups of male rats strain Wistar treated as follows: Normal control, negative control, positive control (metformin tablets), basis group, placebo treatment group, F1, F2, and F3 groups. The antidiabetic activity was evaluated from a decrease in rat blood glucose levels. Previously, rats were induced first using alloxan 150 mg/kg intraperitoneally to damage β-pancreatic cells so that the rats could experience increased blood glucose levels. After giving treatment to each group for 14 days, a rat blood sample was then taken on days 9 and 14, which were then analyzed by the GOD PAP method with readings carried out using a spectrophotometer with a wavelength of 500 nm. RESULTS: The average weight (mg) of FI tablets (617.8 ± 3.21%), FII (629.35 ± 8.16%), and FIII (643.6 ± 6.21%), and placebo tablet (666.45 ± 4.36%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). For the hardness values of FI (5.7 kg), FII (1.31 kg), and FIII (3.09 kg), placebo tablet (2.98%). The value of friability FI (1.42%), FII (11.8%), and FIII (0.84%), placebo tablet (1.16%). While the disintegration time of FI (11.02 min), FII (10.10 min), and FIII (17.00 min), placebo tablet (12.23%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). Whereas the dissolution rate (DE45) of each formulation decreased with increasing dose of extract, FI (73.73%), FII (74.80%), and FIII (69.80%). The treatment group of the ethanol extract of fig leaves at a dose of 40 mg, ethanol extract of fig leaves at a dose of 60 mg, and ethanol extract of fig leaves at a dose of 80 mg could reduce rats’ blood glucose levels with statistically significant results (p < 0.05) compared to negative group. When it was compared to the positive group, it had significant results with a statistical value (p < 0.05). CONCLUSION: Ethanol extract of fig leaf tablets had a significant effect on lowering rats’ blood glucose levels.

show abstract

“…Penderita diabetes melitus tipe-2 biasanya mengkonsumsi glibenklamid untuk menurunkan kadar glukosa darah dikarenakan mampu menstimuli sekresi insulin (Baroroh et al, 2011). Pemberian glibenklamid secara terus menerus dapat menimbulkan degranulasi pada sel-sel β-pankreas (Ling et al, 2006).…”

Section: Pendahuluanunclassified

Pengaruh Ekstrak Daun dan Buah Ketapang Terhadap Malondialdehida Pankreas Rattus norvegicus Jantan dengan Hiperglikemia yang Diinduksi Aloksan dan Pakan Tinggi Lemak

Satrianawaty

Christela

Josua

et al. 2019

HTMJ

View full text Add to dashboard Cite

<pre>Diabetes mellitus is a chronic disease caused by high levels of blood glucose. A high-fat diet can cause hyperglycemia .Hyperglycemia will cause the formation of free radicals which can damage cells. Aloksan is a chemical that can damage beta cells, resulting in decreased insulin production. Ketapang (Terminalia catappa) is a plant that can be used because of its antioxidant content. The administration of ketapang extract (Terminalia catappa) is thought to reduce levels of malondialdehyde. Malondialdehyde is a biomarker for the occurrence of lipid peroxidation in the body caused by an increase in free radicals due to the occurrence of oxidative stress.</pre> This study used Wistar rats divided into 4 groups. Three groups will be given high-fat diet for 7 days followed by induced alloxan at a dose of 90 mg / kgBW to increase blood glucose levels and pancreatic malondialdehyde levels. Then 2 groups will be given treatment for 14 days. The first treatment group was given Ketapang extract with a dose of 600 mg / kgBW and the second treatment group which was given glibenclamide using a dose of 0.09 mg / kgBW.<pre> The results showed that there was a significant decrease in pancreatic malondialdehyde in Wistar rats induced by glibenclamide (p = 0.016). In the group induced by ketapang leaf and fruit extract (Terminalia catappa) there was a decrease in malondialdehyde levels but was not significant (p = 0.916).</pre> Conclusions, this study indicated that the administration of ketapang leaf and fruit (Terminalia catappa) extract were able to reduce the levels of pancreatic malondialdehyde given a high-fat diet and induced by alloxan.

show abstract

UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR

Abstract: (-60), 0, 30, 60, 120, 180, 240, dan

Cited by 7 publications

References 0 publications

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KACA PIRING (Gardenia jasminoides Ellis) TERHADAP TIKUS PUTIH BETINA (Rattus norvegicus L.) GALUR WISTAR

UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN KACA PIRING (Gardenia jasminoides Ellis) TERHADAP TIKUS PUTIH BETINA (Rattus norvegicus L.) GALUR WISTAR

The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats

Pengaruh Ekstrak Daun dan Buah Ketapang Terhadap Malondialdehida Pankreas Rattus norvegicus Jantan dengan Hiperglikemia yang Diinduksi Aloksan dan Pakan Tinggi Lemak

Contact Info

Product

Resources

About