Über Kältehämoglobinurie

Donath, Julius; Landsteiner, Karl

doi:10.1007/978-3-642-92404-0_3

Cited by 8 publications

(7 citation statements)

References 53 publications

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“…This is particularly interesting in view of what occurs when a patient spontaneously has a paroxysm. The actual time during which the PROTOCOL 1 December 7,1922. Patient L. 0.…”

mentioning

confidence: 99%

“…Patient F. V. Blood drawn from arm vein; one portion was allowed to clot at room temperature; serum separated as soon as clot had formed and test set up at once; a second portion was citrated and used for the preparation of the red cell suspension. Control Another question upon which discordant results have been reported (6,7) is the possible effect of CO2 either as a substitute for chilling or as an auxilliary factor in bringing about union of the hemolysin and the red cells. The experiments I have done with CO2 were entirely negative (8).…”

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confidence: 99%

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Observations on Paroxysmal Hemoglobinuria 1

Mackenzie

Frühbauer²

1929

J. Clin. Invest.

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“…This is particularly interesting in view of what occurs when a patient spontaneously has a paroxysm. The actual time during which the PROTOCOL 1 December 7,1922. Patient L. 0.…”

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confidence: 99%

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confidence: 99%

Observations on Paroxysmal Hemoglobinuria 1

Mackenzie

Frühbauer²

1929

J. Clin. Invest.

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“…Old serum 4 The experiments performed were identical with those described under "heat-inactivated serum" and the results were the same, i.e., marked hemolysis occurred only when the cells were tapped in the cold.…”

Section: Demonstration Of the Cold Hemolysis Phenomenonmentioning

confidence: 71%

Cold Hemagglutination and Cold Hemolysis. The Hemolysis Produced by Shaking Cold Agglutinated Erythrocytes

Stats¹

1945

J. Clin. Invest.

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“…There is for instance not yet a definite explanation for the occur- Mention may also be made of the autohemagglutinins found in infections with protozoa and of autohemolysins (paroxysmal hemoglobinuria), apparently specific (20,21) for human blood in cases of syphilis, though this phenomenon is rarely met with. Perhaps these observations may be indicative of an autoimmunization.…”

Section: Discussionmentioning

confidence: 99%

Experiments on the Production of Wassermann Reagins by Means of Trypanosomes

Landsteiner

Scheer

1927

Journal of Experimental Medicine

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According to the original view of the discoverers the Wassermann reaction was considered, in analogy to the common serological reactions, as being caused by antibodies specific for the infecting microorganisms. This view became doubtful and was abandoned by most authors when it was shown that syphilitic sera react with alcoholic extracts of organs, presumably with lipoids present in these extracts (1-3). The use of extracts of normal instead of syphilitic organs (1) has since been accepted almost generally for the technique of the Wassermann reaction. Several main hypotheses have been advanced in order to explain the formation and properties of the Wassermann reagins. Some authors believed that the action of the syphilitic sera was due not to immune bodies but to non-specific changes of the serum proteins. Others regarded, the reagins as antibodies formed either by autoimmunization with lipoidal substances from the infected organism or with lipoids derived from the spirochetes (cf. Bergel). In the latter case one had to assume that the antibodies produced act not only upon the homologous antigen but also upon lipoids of very different origin.The hypotheses implying an immunization against lipoids met with the difficulty that the attempts to induce the formation of antibodies by injection of lipoids, as a rule, did not yield clear-cut and consistent results. In the positive experiments recorded there was no certainty as to the absence of small quantities of antigenic proteins in the material injected or else the amount of antibody formation was rather insignificant. I 1 Regarding the antigens of blood corpuscles see "On the antigens of red blood corpuscles. The question of lipoid antigens," by K. Landsteiner and J. van der Scheer,

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Über Kältehämoglobinurie

Cited by 8 publications

References 53 publications

Observations on Paroxysmal Hemoglobinuria 1

Observations on Paroxysmal Hemoglobinuria 1

Cold Hemagglutination and Cold Hemolysis. The Hemolysis Produced by Shaking Cold Agglutinated Erythrocytes

Experiments on the Production of Wassermann Reagins by Means of Trypanosomes

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