1929
DOI: 10.1172/jci100219
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Observations on Paroxysmal Hemoglobinuria 1

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1937
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Cited by 12 publications
(5 citation statements)
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“…Agglutination following the cold phase was slight and the cells were easily resuspended, in contrast to the marked agglutinating properties of hemolytic amounts of isoantibodies or to cold agglutinins. It is further noted that hemolysin activity was present in a fraction which contained little or none of the Kline antibody, corroborating observations made many times previously (8,27) that the D-L antibody is distinct from the antibody responsible for the serologic tests for syphilis.…”
Section: H the Kinetics Of The Hemolytic Reactionsupporting
confidence: 86%
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“…Agglutination following the cold phase was slight and the cells were easily resuspended, in contrast to the marked agglutinating properties of hemolytic amounts of isoantibodies or to cold agglutinins. It is further noted that hemolysin activity was present in a fraction which contained little or none of the Kline antibody, corroborating observations made many times previously (8,27) that the D-L antibody is distinct from the antibody responsible for the serologic tests for syphilis.…”
Section: H the Kinetics Of The Hemolytic Reactionsupporting
confidence: 86%
“…DISCUSSION There have been many conflicting reports concerning the properties of the D-L antibody and the characteristics of the hemolytic reaction. A number of early investigators (7,8) in their original observations demonstrated that hemolysis occurred even though fresh serum was not present in the initial cold phase. Hoover and Stone, Moss, and Cooke (4-6) demonstrated that fresh serum as a source of complement was required in the cold phase with the antibodies they were studying.…”
Section: H the Kinetics Of The Hemolytic Reactionmentioning
confidence: 99%
“…As a result of infection with the spirochete of syphilis (2,3), the patient produces a factor that, under proper conditions, hemolyzes his own erythrocytes. Hemoglobinuria is thus a dramatic manifestation of the ability of an infectious agent to induce the body to destroy one of its tissues.…”
mentioning
confidence: 99%
“…Hemoglobinuria is thus a dramatic manifestation of the ability of an infectious agent to induce the body to destroy one of its tissues. Such "auto-immunization" is not dependent on any specific blood group antigen (2,3), and the serum antibody is active not only against the patient's erythrocytes but also against erythrocytes from other individuals.…”
mentioning
confidence: 99%
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