1951
DOI: 10.1172/jci102412
|View full text |Cite
|
Sign up to set email alerts
|

The Mechanism of Hemolysis in Paroxysmal Cold Hemoglobinuria. Ii. Observations on the Behavior and Nature of the Antibody 1

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
11
0
1

Year Published

1951
1951
1983
1983

Publication Types

Select...
7
3

Relationship

1
9

Authors

Journals

citations
Cited by 21 publications
(12 citation statements)
references
References 6 publications
0
11
0
1
Order By: Relevance
“…In our patient the direct antiglobulin test remained positive with antiblobulin re agents containing anti-complement compo nents. Although the D-L antibody is known to be a biphasic hemolysin, it may exhibit agglutinating ability at a lower temperature [14], as was exhibited in the serum and red cell eluates of our patient (table II).…”
Section: Serological Studiesmentioning
confidence: 63%
“…In our patient the direct antiglobulin test remained positive with antiblobulin re agents containing anti-complement compo nents. Although the D-L antibody is known to be a biphasic hemolysin, it may exhibit agglutinating ability at a lower temperature [14], as was exhibited in the serum and red cell eluates of our patient (table II).…”
Section: Serological Studiesmentioning
confidence: 63%
“…In contrast, the immunological character of paroxysmal cold hemoglobinuria is unique in that it requires complement for antibody fixation as well as for subsequent hemolysis. Characterization of the PCH antibody has not helped to explain this phenomenon, since the hemolysin is a gammaglobulin of the pseudoglobulin type (25) and thus falls in the same class as other antibodies.…”
Section: Discussionmentioning
confidence: 99%
“…Perhaps another analogy again exists in the interaction of erythrocytes with cold or "incomplete" antibodies. In this reaction serum factors resembling complement, are required for the combination of the antibody with the erythrocyte ("cold phase") and for the hemolysis of the cell ("warm phase") 13,14 The dual and different requirements for the interaction of properdin could be" considered biologically economic. The bactericidal activity of the properdin system which appears to require all four components of complement results in bacteriolysis.…”
Section: W Edgw Ood and P Illem Ermentioning
confidence: 99%