The Nature and Interactions of the Properdin System

Wedgwood, Ralph; Pillemer, Louis

doi:10.1159/000205491

Cited by 15 publications

(4 citation statements)

References 2 publications

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“…Listed in table 5 are the known properties of this material, properdin, which has such diverse and striking actions. Properdin is a protein which by earlier studies of its physical properties was considered to be a 3-2-globulin (63). However, the electrophoretic characteristics and other physical properties suggest that a preferable terminology by current convention is that of a -y-1-globulin (37).…”

Section: Inactivation Of Newcastle Disease Virusmentioning

confidence: 99%

Serum and Tissue Inhibitors of Virus

Ginsberg¹

1960

Bacteriological Reviews

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Section: Inactivation Of Newcastle Disease Virusmentioning

confidence: 99%

Serum and Tissue Inhibitors of Virus

Ginsberg¹

1960

Bacteriological Reviews

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“…By the 1930s, a “classical pathway” of the sequential activation of four serum complement fractions C1-C4-C2-C3, had been characterized, triggered by infection-specific immune reactants. This remained the only recognized complement activation pathway until the late 1950s ( 7 ), when Louis Pillemer, at Western Reserve University, introduced the notion of an “alternative pathway” with his discovery of properdin ( 8 , 9 ). The relevance of this alternative pathway is now acknowledged for its central importance in health and disease.…”

Section: Introductionmentioning

confidence: 99%

Coagulation and complement: Key innate defense participants in a seamless web

2022

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In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is activated and complement is regulated, wrote, “In the study of biological processes, the accumulation of information is often accelerated by a narrow point of view. The fastest way to investigate the body’s defenses against injury is to look individually at such isolated questions as how the blood clots or how complement works. We must constantly remind ourselves that such distinctions are man-made. In life, as in the legal cliché, the devices through which the body protects itself form a seamless web, unwrinkled by our artificialities.” Our aim in this review, is to highlight the critical molecular and cellular interactions between coagulation and complement, and how these two major component proteolytic pathways contribute to the seamless web of innate mechanisms that the body uses to protect itself from injury, invading pathogens and foreign surfaces.

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“…N el so n (11) in 1958, postulated its effect as that of an antibody, thereby trans ferring it into the field of acquired immunity. Pillemer in 1958 (12) now believe properdin to be a "peculiar type of antibody", very non-specific and differing from conventional antibody systems.…”

Section: Introductionmentioning

confidence: 99%