1958
DOI: 10.1159/000205491
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The Nature and Interactions of the Properdin System

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1959
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Cited by 15 publications
(4 citation statements)
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“…Listed in table 5 are the known properties of this material, properdin, which has such diverse and striking actions. Properdin is a protein which by earlier studies of its physical properties was considered to be a 3-2-globulin (63). However, the electrophoretic characteristics and other physical properties suggest that a preferable terminology by current convention is that of a -y-1-globulin (37).…”
Section: Inactivation Of Newcastle Disease Virusmentioning
confidence: 99%
“…Listed in table 5 are the known properties of this material, properdin, which has such diverse and striking actions. Properdin is a protein which by earlier studies of its physical properties was considered to be a 3-2-globulin (63). However, the electrophoretic characteristics and other physical properties suggest that a preferable terminology by current convention is that of a -y-1-globulin (37).…”
Section: Inactivation Of Newcastle Disease Virusmentioning
confidence: 99%
“…By the 1930s, a “classical pathway” of the sequential activation of four serum complement fractions C1-C4-C2-C3, had been characterized, triggered by infection-specific immune reactants. This remained the only recognized complement activation pathway until the late 1950s ( 7 ), when Louis Pillemer, at Western Reserve University, introduced the notion of an “alternative pathway” with his discovery of properdin ( 8 , 9 ). The relevance of this alternative pathway is now acknowledged for its central importance in health and disease.…”
Section: Introductionmentioning
confidence: 99%
“…N el so n (11) in 1958, postulated its effect as that of an antibody, thereby trans ferring it into the field of acquired immunity. Pillemer in 1958 (12) now believe properdin to be a "peculiar type of antibody", very non-specific and differing from conventional antibody systems.…”
Section: Introductionmentioning
confidence: 99%