Über die Wirkstoffe von Asarum europaeum

Abstract

The local anaesthetic activity of both phenylpropanoids of ASARUM EUROPAEUM trans-isoasarone and trans-isoeugenol methyl ether were measured in comparison to the unsubstituted propenyl benzene and to the mono methoxy derivative trans-anethole resp. benzocaine, trans-Isosarone shows local anaesthetic activity with an intensity nearly equal to benzocaine. The quantitative structure-activity relationship in the series of phenylpropanoids has been analysed and established that the activity is increasing according to the number of methoxy groups. The results are compared with the lipophility and the surface activity of the substances. Surface activity changes parallel with the anaesthetic activity while the lipophility changes in contrary.

Antibacterial and antitumour activities of some plants grown in Turkey

“…No tumour formation (100% tumour inhibition) ( Table 4 ) was observed with aqueous extract of A. europaeum that was one of the best tested plants exhibiting strong antibacterial activities against all used bacteria except S. pyogenes in our study ( Tables 2 and 3 ). Gracza [ 16 ] determined and evaluated the biologic activities (local anesthetic and expectorant) of the phenylpropanoids found in A. eurapeum . The phenylpropanoid ingredient of A. europaeum may contribute to the demonstrated strong antibacterial and antitumour activities.…”

“…[ 15 ] Asarum eurapeum contains phenylpropanoids leading to local anesthetic and expectorant activities. [ 16 ] Toth et al. [ 17 ] described the flavonoids of Rhinanthus angustifolius .…”

Asarum Europaeum L. O‘SIMLIGI Tarkibidagi Biologik Faol Moddalarni Aniqlash

“…So far, the chemical composition of the Asarum europaeum L. and their biological activity have not been studied in Uzbekistan. The primary goal of researching this greenery is to identify biologically active substances contained in the plant Asarum europaeum L [11][12].…”

“…Shu paytgacha O'zbekistonda o'suvchi Аsarum europaeum L. o'simligining kimyoviy tarkibi va ularning biologik faolligi o'rganilmagan. Тadqiqotning asosiy maqsadi Аsarum europaeum L. o'simligi tarkibidagi biologik faol moddalarni aniqlashdan iboratdir [11][12].…”

Constituents of Asarum sieboldii with Inhibitory Activity on Lipopolysaccharide (LPS)‐Induced NO Production in BV‐2 Microglial Cells

“…-The Asarum species (Aristolochiaceae) are herbal plants distributed through North America, Europe, and Asia [1]. The roots of these species were used in traditional medicine as antitussive [2], anti-allergic [3], antihyperlipemic [4], expectorant [5] [6], anti-inflammatory [7] [8], anesthetic [9], and antifungal agents [10] [11]. Previous phytochemical work on Asarum species resulted in the isolation of various types of essential oils [5] [12] [13], amides [14] [15], lignans [14] [16], flavonoids [17] [18], terpenoids [19], and alkaloids [20].…”