Über den Wert der Serumtherapie bei Diphtherie, insbesondere bei der malignen, toxischen Form

Adolf Bingel's blinded, controlled comparison of different anti-diphtheritic sera in 1918

“…Bingel's defence was clearly persuasive to some clinicians, however, and his request that his trial be replicated was taken up by some other researchers. In 1933, for example, stimulated by Bingel's findings and their own observations of the effects of normal horse serum on the Schick reaction, Hottinger and Toepfer 6 reported four separate trials using alternation to generate comparison groups, some using untreated controls. The largest of these trials alternated 400 patients to either anti-toxin serum or normal serum.…”

“…The largest of these trials alternated 400 patients to either anti-toxin serum or normal serum. 6 Like Bingel, Hottinger and Toepfer were unable to detect any differential effects of the two sera, although they stressed that their sample sizes had been inadequate to dismiss the possibility that important differences might exist. They also reiterated that the responses of infected animals to sera might well differ from the responses of diseased patients.…”