U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women

Lee, Yea-Chan; Son, Da‐Hye; Kwon, Yu‐Jin

doi:10.3390/ijerph17082657

Cited by 15 publications

(18 citation statements)

References 43 publications

(67 reference statements)

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“…This study provides further evidence that sleep duration is independently associated with hyperuricemia after adjusting for known risk factors and potential confounders. Unlike a U-shaped curve reported in Korean women [22], our findings indicated that longer sleep (>8 h) could also reduce the incidence of hyperuricemia significantly, which was consistent with previous studies [23,32]. In this prospective longitudinal study, sufficient samples and prospective study design avoided reverse causality by chronological order.…”

Section: Discussionsupporting

confidence: 90%

“…In this study, only 36.16% of participants had a recommended sleep duration, and over one-half of participants slept less than 7 h. Our results are in line with several previous studies that estimated the association of sleep duration with hyperuricemia. Consistent with previous cross-sectional studies [22,23,31], short sleep duration was considered as a risk factor for hyperuricemia in this study. Appropriate public health actions should be taken to increase the sleep time of the population to reduce the damage to health caused by sleep that is too short, especially among subgroups with a low HDL-C, a high TG, or those who are not overweight.…”

Section: Discussionsupporting

confidence: 75%

“…However, there is still a lack of research on the relationship between sleep duration and uric acid levels. A recent cross-sectional study showed a U-shaped relationship between sleep duration and uric acid levels in Korean women [22]. The risk for higher serum UA increased 54% in the short sleep duration group and 94% in long group, compared with that in participants who slept for 7-8 h. Moreover, evidence from an elderly Mediterranean population showed an inverse association between sleep duration and serum UA concentrations [23].…”

Section: Introductionmentioning

confidence: 97%

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Association of Sleep Duration with Hyperuricemia in Chinese Adults: A Prospective Longitudinal Study

Shi²,

Sun³

et al. 2022

IJERPH

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Little is known about the association of sleep duration with hyperuricemia. Especially lacking is evidence from longitudinal studies. Based on the MJ Health Examination Database in Beijing, China, a prospective study was designed. Participants were classed into short, normal, and long groups by sleep duration. The Cox regression model was used to estimate the hazard risk of hyperuricemia for short or long sleep duration compared with the normal group after adjusting for potential confounders. During a median 3.08 years follow-up, 4868 (14.31%) incident hyperuricemia events were documented among 34,025 participants with a crude incidence rate of 39.49 per 1000 persons. Years after adjusting for potential confounders, a 7% higher risk of hyperuricemia in the short sleep duration group (<7 h, 95% confidence interval: 1.01–1.14) and a 15% lower risk in the long sleep duration group (≥8 h, 95%CI: 0.74–0.97) were found compared with the normal group (7–8 h) (p for trend < 0.001). Nevertheless, the association of the short sleep duration group was marginally significant after further adjustment of the count of white blood cells (hazard ratio: 1.07, 95%CI: 1.00 –1.13). Sleep duration was inversely associated with hyperuricemia, which highlights the public health significance of sufficient sleep duration for preventing hyperuricemia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 97%

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Association of Sleep Duration with Hyperuricemia in Chinese Adults: A Prospective Longitudinal Study

Shi²,

Sun³

et al. 2022

IJERPH

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“…First, a major explanation is inflammation, a key factor strongly associated with depression [ 33 ]. Studies have reported both short and long sleep durations and poor sleep quality to be associated with increased inflammatory cytokines such as CRP and IL6 [ 34 – 36 ]. Second, good sleep quality could help increase levels of melatonin [ 37 ], a pleiotropic regulator molecule that has been reported to alleviate depressive symptoms [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

The association of sleep duration and quality with depressive symptoms in older Chinese women

et al. 2022

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Poor sleep quality or short and long sleep duration are associated with many negative health outcomes, such as diabetes, hypertension, and fatigue, which may directly or indirectly correlate with poor mental health. Although, the association between sleep duration and quality, and depressive symptoms has been examined, the results of these studies were inconsistent and evidence specifically on older women is lacking. Therefore, we designed a cross-sectional study to evaluate the association between sleep duration and quality, and depressive symptoms in a relatively large sample of older Chinese women. The data were collected from 1,429 older women aged ≥60 years during bone-health examinations in Shanghai. Information on sleep duration and quality were assessed using a self-reported questionnaire. Depressive symptoms were assessed using the Zung self-rating depression scale (SDS), and depressive symptoms were considered present for SDS scores ≥ 45. Logistic regression models were used to analyze the association between sleep and depressive symptoms. After adjusting for all potential confounding factors, a J-shaped association was found between sleep duration and depressive symptoms. When a sleep duration of 6–8 hours was set as a reference, the odds ratios and 95% confidential intervals of short and long sleep duration were 1.31 (0.99, 1.73) and 2.10 (1.40, 3.16), respectively. Moreover, sleep quality was inversely associated with the prevalence of depressive symptoms (p for trend = 0.040). When the SDS cut-off score defining depressive symptoms was changed to 40 and 50, these associations were somewhat weakened, but the trend did not change. This study replicated and extended prior research findings that sleep duration and quality may influence mental health in older women.

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“…Moreover, as standard MR is based on the assumption of linearity (24), it would overlook non-linear effects (25). Given that a U-shaped observational association between sleep duration and hyperuricemia was reported in a previous study (18), it is a key research priority to explore the potential non-linear causal relationship between sleep duration and hyperuricemia.…”

Section: Introductionmentioning

confidence: 93%

Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

Zou

Wang

et al. 2022

Front. Nutr.

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BackgroundObservational studies have suggested a potential non-linear association between sleep duration and hyperuricemia. However, the causal nature and sex-specific differences are poorly understood. We aimed to determine the shape of sex-specific causal associations between sleep duration and hyperuricemia in the UK Biobank.MethodsLogistic regression was used to investigate the observational association between self-reported sleep duration and hyperuricemia among 387,980 white British participants (mean age: 56.9 years and 46.0% males). Linear and non-linear Mendelian Randomization (MR) analyses were performed to assess the causal association between continuous sleep duration and hyperuricemia. The causal effects of genetically predicted short (<7 h) and long (>8 h) sleep durations on hyperuricemia were further estimated, respectively.ResultsTraditional observational analysis suggested U- and J-shaped associations between sleep duration and hyperuricemia in females and males, respectively. Linear MR did not support the causal effect of sleep duration on hyperuricemia. Non-linear MR demonstrated an approximately U-shaped causal association between continuous sleep duration and hyperuricemia in overall participants and females, but not in males. Genetically predicted short sleep duration was significantly associated with hyperuricemia in females (OR [95% CI]: 1.21 [1.08–1.36]; P = 0.001), but not in males (1.08 [0.98–1.18]; P = 0.137). By contrast, genetically predicted long sleep duration was not significantly associated with the risk of hyperuricemia in either females or males.ConclusionGenetically predicted short sleep duration is a potential causal risk factor for hyperuricemia for females but has little effect on males. Long sleep duration does not appear to be causally associated with hyperuricemia.

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U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women

Cited by 15 publications

References 43 publications

Association of Sleep Duration with Hyperuricemia in Chinese Adults: A Prospective Longitudinal Study

Association of Sleep Duration with Hyperuricemia in Chinese Adults: A Prospective Longitudinal Study

The association of sleep duration and quality with depressive symptoms in older Chinese women

Linear and non-linear Mendelian randomization analyses of sex-specific associations between sleep duration and hyperuricemia

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