Type 2 diabetes and risk of hospital admission or death for chronic liver diseases

Wild, Sarah H.; Morling, Joanne R; McAllister, David A; Kerssens, J.J.; Fischbacher, Colin; Parkes, Julie; Roderick, Paul; Sattar, Naveed; Byrne, Christopher D.

doi:10.1016/j.jhep.2016.01.014

Cited by 67 publications

(28 citation statements)

References 29 publications

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“…The liver is crucial to carbohydrate metabolism and glucose homoeostasis, and hepatic dysfunction causes glucose abnormalities that can lead to the development of DM, which is prevalent in chronic liver disease patients. 33,34 Non-alcoholic fatty liver disease, alcoholic liver disease and HCV infection have been found to be strongly associated with T2DM. [35][36][37] However, the relationship between HBV infection and T2DM remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Comparison of type 2 diabetes mellitus incidence in different phases of hepatitis B virus infection: A meta‐analysis

Shen

Zhang

Wang

et al. 2017

Liver International

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Section: Discussionmentioning

confidence: 99%

Comparison of type 2 diabetes mellitus incidence in different phases of hepatitis B virus infection: A meta‐analysis

Shen

Zhang

Wang

et al. 2017

Liver International

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“…Patients with NAFLD and T2D have a high prevalence of NASH and advanced fibrosis[3,15,57-59], and consistently, T2D is a strong predictor of the severity and progression of histologically assessed hepatic fibrosis[25,27,57,60]. Moreover, T2D is also an important predictor of the development of HCC[61,62] and an increased risk of all-cause and liver-related mortality[60,63,64]. …”

Section: Nafldmentioning

confidence: 99%

Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV

Lonardo¹,

Ballestri²,

Guaraldi³

et al. 2016

WJG

101

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Fatty liver, which frequently coexists with necro-inflammatory and fibrotic changes, may occur in the setting of nonalcoholic fatty liver disease (NAFLD) and chronic infections due to either hepatitis C virus (HCV) or human immunodeficiency virus (HIV). These three pathologic conditions are associated with an increased prevalence and incidence of cardiovascular disease (CVD) and type 2 diabetes (T2D). In this multidisciplinary clinical review, we aim to discuss the ever-expanding wealth of clinical and epidemiological evidence supporting a key role of fatty liver in the development of T2D and CVD in patients with NAFLD and in those with HCV or HIV infections. For each of these three common diseases, the epidemiological features, pathophysiologic mechanisms and clinical implications of the presence of fatty liver in predicting the risk of incident T2D and CVD are examined in depth. Collectively, the data discussed in this updated review, which follows an innovative comparative approach, further reinforce the conclusion that the presence of fatty/inflamed/fibrotic liver might be a shared important determinant for the development of T2D and CVD in patients with NAFLD, HCV or HIV. This review may also open new avenues in the clinical and research arenas and paves the way for the planning of future, well-designed prospective and intervention studies.

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“…In the last few years, a gradual increase in incidences has been reported, inducing metabolic alterations and cardiovascular complications [129][130][131]. Early treatment with dietary and/or pharmacological hygienic measures in patients with prediabetic states can reduce the incidence of diabetes [132]. However, clearly there is a genetic predisposition that is favored by some factors such as obesity or a sedentary lifestyle [133][134][135].…”

Section: Native Chilean Fruits As a Source Of Antioxidantsmentioning

confidence: 99%

Native Chilean Fruits and the Effects of their Functional Compounds on Human Health

Ulloa-Inostroza¹,

Ulloa-Inostroza²,

Alberdi³

et al. 2017

Superfood and Functional Food - An Overview of Their Processing and Utilization

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In recent years, there has been great interest in the nutraceutical compounds of fruits from native Chilean plant species. In this context, fruits of Amomyrtus meli (Meli), Aristotelia chilensis (Maqui), Berberis microphylla (Calafate), Luma apiculata (Arrayán), Luma chequén (Chequén), and Ugni molinae (Murtilla) growing predominantly in Chilean forests have been studied. This chapter has compiled the existing information about antioxidant activity and antioxidant compound contents of the above mentioned fruit species and their association with the prevention of pathophysiological disorders in humans, such as inflammation, diabetes, and cardiovascular diseases. Results show that the antioxidant compounds of these species, particularly anthocyanins, decrease inflammation as well as the risk of diabetes and cardiovascular diseases. Therefore, consumption of these fruits is a good alternative for preventing cardiovascular and age-related diseases and pathophysiological disorders.

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Type 2 diabetes and risk of hospital admission or death for chronic liver diseases

Cited by 67 publications

References 29 publications

Comparison of type 2 diabetes mellitus incidence in different phases of hepatitis B virus infection: A meta‐analysis

Comparison of type 2 diabetes mellitus incidence in different phases of hepatitis B virus infection: A meta‐analysis

Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV

Native Chilean Fruits and the Effects of their Functional Compounds on Human Health

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