Native Chilean Fruits and the Effects of their Functional Compounds on Human Health

Ulloa-Inostroza, Elizabeth M.; Ulloa-Inostroza, Eric G.; Alberdi, Daniela Peña-Sanhueza Miren; González‐Villagra, Jorge; Jaakola, Laura; Reyes‐Díaz, Marjorie

doi:10.5772/67067

Cited by 10 publications

(24 citation statements)

References 138 publications

(203 reference statements)

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“…Regarding the polyphenol composition of the Patagonian berries, Maqui and Calafate have anthocyanins as the main molecule (Brito et al 2014;Fuentes et al 2016;Ruiz et al 2010Ruiz et al , 2013aSchmeda-Hirschmann et al 2019;Simirgiotis et al 2013;Ulloa-Inostroza et al 2017). As expected, our results showed that anthocyanin-rich extracts of Calafate fruits presented higher total anthocyanin concentration (32 mg cyanidin 3-O-glucoside g −1 DW) compared to crude extracts (25 mg cyanidin 3-O-glucoside g −1 DW), which were increased concomitant at increasing extract concentration.…”

Section: Discussionsupporting

confidence: 79%

“…Plant phenolics have radical scavenging and metal chelating potential, being useful to the treatment of worldwide diseases like cardiovascular disorders and cancer (Mocan et al 2016). In Chilean Patagonia, edible fruits of the woody or shrub forest species belonging to the Berberidaceae family, such as Calafate, are rich in antioxidant compounds (Brito et al 2014;Fuentes et al 2016;Ruiz et al 2010;Schmeda-Hirschmann et al 2019;Simirgiotis et al 2013;Ulloa-Inostroza et al 2017). Our results showed that the antioxidant activity, as well as total phenols and total anthocyanin content of Calafate extracts, increased concomitant with the increase of extract concentrations.…”

Section: Discussionmentioning

confidence: 61%

“…As expected, our results showed that anthocyanin-rich extracts of Calafate fruits presented higher total anthocyanin concentration (32 mg cyanidin 3-O-glucoside g −1 DW) compared to crude extracts (25 mg cyanidin 3-O-glucoside g −1 DW), which were increased concomitant at increasing extract concentration. Several works suggest that the highest total anthocyanin content of berries can be found in Calafate and Maqui fruits, especially those harvested in the Chilean Patagonia (Ruiz et al 2010(Ruiz et al , 2013aUlloa-Inostroza et al 2017). Also, it was reported that the total anthocyanin contents were higher in Calafate fruit extract (between 23 and 36 μmol g −1 FW) (Ruiz et al 2013a), followed by Maqui berries (between 16 and 20 μmol g −1 FW), being all high values compared to those detected in blueberries (2.0 μmol g −1 FW) (Ruiz et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…(Calafate) is a native berry from southern Patagonia in Chile and Argentina (Ruiz et al 2010), belonging to the Berberidaceae family (Mariangel et al 2013;Ramirez et al 2015). It is an evergreen shrub 2-3 m high with trifid thorns and little single yellow flowers, which in Chile is grown under wild conditions from Maule to Magallanes regions (Ulloa-Inostroza et al 2017). Calafate fruits are dark blue-purple berries (7-11 mm caliber) (Mariangel et al 2013) that generally are consumed fresh or as jellies, marmalades, and wines (Ruiz et al 2010;Ulloa-Inostroza et al 2017), being recognized by their remarkable antioxidant properties and high content of anthocyanins (Chamorro et al 2019;Ruiz et al 2013a).…”

Section: Introductionmentioning

confidence: 99%

“…It is an evergreen shrub 2-3 m high with trifid thorns and little single yellow flowers, which in Chile is grown under wild conditions from Maule to Magallanes regions (Ulloa-Inostroza et al 2017). Calafate fruits are dark blue-purple berries (7-11 mm caliber) (Mariangel et al 2013) that generally are consumed fresh or as jellies, marmalades, and wines (Ruiz et al 2010;Ulloa-Inostroza et al 2017), being recognized by their remarkable antioxidant properties and high content of anthocyanins (Chamorro et al 2019;Ruiz et al 2013a). Thus, Calafate fruits appear as a new alternative of nutraceutical products potentially useful for the treatment of different degenerative diseases of public interest (Ruiz et al 2013a), which has been poorly explored for this purpose.…”

Section: Introductionmentioning

confidence: 99%

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Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

Calderón-Reyes

Pezoa

Leal

et al. 2020

J Soil Sci Plant Nutr

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Currently, gastric cancer (GC) and gallbladder cancer (GBC) constitute important causes of human deaths related to cancer worldwide. In the last years, several researches are focused on the role of dietary compounds in preventing cancers. The consumption of fruits with high antioxidants, mainly anthocyanins, represents a good option to reduce the risk of chronic human diseases. Calafate (Berberis microphylla G. Forst.) berries, recognized by their remarkable antioxidant properties and high content of anthocyanins, appear as a new alternative to treat degenerative diseases of public interest. The present work was aimed to evaluate the impact of crude and anthocyanin-rich extracts from Calafate fruits on in vitro cell viability and migration capacity of gastric (AGC) and gallbladder (G415) human cancer cell lines, as related with their antioxidant properties. Crude and anthocyanin-rich extracts were obtained from fruits of Calafate grown under field conditions in the south of Chile. Antioxidants, phenols, anthocyanins, and anthocyanidins were determined. In vitro cell viability and migration of AGS and G415 human cancer cell lines at different concentrations of extracts (25-800 μg mL −1) were determined. Anthocyanin-rich extracts of Calafate berries showed comparable antioxidant activity (up to 1200 μg Trolox eq. g −1 DW), slightly lower total phenolic content (12%), but higher total anthocyanin content (25%) compared to the crude extract. The major anthocyanidin molecule detected in both extracts was delphinidin, followed by malvidin, and low concentrations of petunidin, cyanidin, and peonidin. As expected, all of these compounds were detected in higher levels in anthocyanin-rich extracts (up to 2-fold). Noteworthy, our study revealed that Calafate fruit extracts strongly decrease in vitro viability and migration capacity of gastric carcinoma (AGC model) and gallbladder carcinoma (G415 model) human cell lines; however, the anthocyanin-rich extract displayed higher inhibitory effects (up to 70%) compared to crude extracts. These findings allow suggesting that the in vitro antiproliferative potential of Calafate fruit extract is strongly related to the anthocyanin concentration, especially delphinidin.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

Calderón-Reyes

Pezoa

Leal

et al. 2020

J Soil Sci Plant Nutr

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Argentine Patagonia barberry chemical composition and evaluation of its antioxidant capacity

et al. 2020

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An important portion of vitamins, minerals and polyphenols components in human diet are captured from fruit consumption. Argentinean Patagonia Berberis microphylla was characterized with the phenolic content, the proximate composition and the identification and quantification of anthocyanins, not‐anthocyanins and proteins. The antioxidant capacity of berberis ethanolic extracts (EB) was determined by the 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assays. EB was used to reduce production of reactive substances species (ROS) in zebrafish. EB presented a total polyphenols content of 1,035.03 mg GAE/100 g fresh weight (FW). EB presented an ABTS value of 116.25 ± 17 μmol TE/g FW. EB presented a DPPH value of 137.80 ± 1.90 μmol TE/g FW. EB was able of reducing the ROS in zebrafish. Berberies Protein Isolate (BPI) presented proteins with bands from 15 to 62 kDa. BPI presented an ABTS value of 593.11 ± 8.60 μmol TE/g. The BPI duodenal digest presented a value of 641.07 ± 12.60 μmol TE/g digests. Practical applications The practical applications of the present study are to increase scientific knowledge for consumers about the quality and benefits of the consumption of the native fruit (Berberis microphylla) from the Patagonia region of Argentine. This work describes the protein profile of berberies, their digestibility and their antioxidant activity. This study allows to better understand the phytonutrients that make up this fruit. Future studies may identify the peptides present in hydrolyzates. The bio‐compounds of this fruit could be used as functional ingredients by the food industry for different purposes.

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Ethnopharmacology, Phytochemistry and Biological Activities of Native Chilean Plants

Salehi

Sharifi‐Rad

Herrera‐Bravo

et al. 2021

CPD

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: The native flora of Chile has unique characteristics due to the geographical situation of the country, with the vast desert in the North, Patagonia in the South, the Andean Mountains on the east and the Pacific Ocean on the west. This exclusivity is reflected in high concentrations of phytochemicals in the fruits and leaves of its native plants. Some examples are Aristotelia chilensis (Molina) Stuntz (maqui), Berberis microphylla G. Forst. (calafate), Peumus boldus Molina (boldo), Ribes magellanicum Poir. (Magellan currant), Ugni molinae Turcz. (murtilla), Rubus geoides Sm. (miñe miñe), Drimys winteri J.R.Forst. & G.Forst. (canelo), Luma apiculata (DC.) Burret (arrayán) distributed throughout the entire Chilean territory. Some of these Chilean plants have been used for centuries in the country's traditional medicine. The most recent studies of phytochemical characterization of parts of Chilean plants show a wide spectrum of antioxidant compounds, phenolic components, terpenoids and alkaloids, which have shown biological activity in both in vitro and in vivo studies. This manuscript covers the entire Chilean territory characterizing the phytochemical profile and reporting some of its biological properties, focusing mainly on antioxidant, anti-inflammatory, antimicrobial, chemopreventive and cytotoxic activity, and potential against diabetes, metabolic syndrome and gastrointestinal disorders.

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Native Chilean Fruits and the Effects of their Functional Compounds on Human Health

Cited by 10 publications

References 138 publications

Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

Anthocyanin-Rich Extracts of Calafate (Berberis microphylla G. Forst.) Fruits Decrease In Vitro Viability and Migration of Human Gastric and Gallbladder Cancer Cell Lines

Argentine Patagonia barberry chemical composition and evaluation of its antioxidant capacity

Ethnopharmacology, Phytochemistry and Biological Activities of Native Chilean Plants

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