Type-1 chain histo-blood group antigens (Lea, monosialosyl-Lea, disialosyl-Lea, Leb, and H) in normal and malignant human endometrium

Abstract

Type-1 chain histo-blood group antigens such as the Lewis (Le)a, monosialosyl-Le(a), Le(b) and H antigens show an increased expression in endometrial carcinomas. However, the possibility that these antigens are expressed under genetic or hormonal influence in endometrial carcinomas has not been considered. In the present study, the expression of type-1 chain carbohydrate antigens in normal and malignant endometrium was evaluated by immunohistochemistry and related to both genetic and hormonal factors. The glands of normal, non-secretory endometria expressed, in contrast with surface epithelial cells, Le(a), Le(b), disialosyl-Le(a), and H determinants infrequently. Adenomatous hyperplasias and endometrial carcinomas showed an increased expression of type-1 chain carbohydrates that was qualitatively influenced by the erythrocyte Lewis phenotype and the secretor status. Whereas Le(a+b-) non-secretors mainly accumulated Le(a) antigen, and only limited amounts of Le(b) antigen, Le(a-b+) secretors expressed H, Le(b) and Le(a) antigens. The expression of type-1 chain antigens showed no association with the serum-oestrogen level or to the hormone-receptor status. Thus the Lewis secretor status has a qualitative influence on the increased expression of type-1 chain antigens, which, however, seem to be unrelated to hormonal factors. Our findings suggest an increased activity of the Se-gene-defined or a closely related fucosyl-transferase in neoplastic endometrial epithelial cells.

Immunohistochemical expression of core 2 β1,6‐N‐acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid‐type endometrial carcinoma: a novel potential prognostic factor

“…Thus, core 2 branches are thought to be involved in metastasis by increasing the adhesiveness of tumour cells to vascular endothelial cells via sialyl Lewis antigens . The expression of sLe x and sLe a in endometrial carcinoma and normal endometrium has also been reported . However, markedly increased expression of sLe x or sLe a in this carcinoma has not been reported.…”