N-acetyllactosamine and sialosyl-N-acetyllactosamine in normal and malignant human endometrium

Ravn, Vibeke; Mandel, Ulla; Svenstrup, Birgit; Dabelsteen, Erik

doi:10.1007/bf00919335

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…We next demonstrated that DU-PAN-2 was expressed more frequently than CA19-9 in EMACs of any grade (G1, G2, G3), and that it was not related to menopausal status [10]. Our analyses are basically similar to those reported by Ravn et al [16,17].…”

Section: Discussionsupporting

confidence: 79%

“…Like other epithelial neoplasms [5,11,14,21], endometrial adenocarcinomas (EMACs) are also characterized by changes in glycosylation involving HBGA [1-3, 16, 17, 22]. The HBGA type of EMACs in many ways shows a resemblance to that of the secretory endometrium, which is characterized by an increased expression of type 1 carbohydrate antigens [15,16]. In our recent studies, the immunohistochemical expressions of DU-PAN-2 and CA19-9 were considered to be strongly dependent on hormonal regulation during the menstrual cycle, with expression peaks in the late secretory phase [4].…”

Section: Discussionmentioning

confidence: 99%

“…Carbohydrate antigen expressions have been proven to undergo qualitative and quantitative alterations during the normal menstrual cycle and a malignant transformation of the endometrium [1-3, Correspondence to: Masanori Yasuda, MD, Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan. [15][16][17][18]22]. Taking advantage of these findings, some investigators have attempted to synthesize monoclonal antibodies specific for endometrial adenocarcinomas (EMACs) [8,12,13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9.

Muramatsu

Yasuda

Osamura

et al. 2002

Acta Histochem. Cytochem

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9.

Muramatsu

Yasuda

Osamura

et al. 2002

Acta Histochem. Cytochem

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“…The terminal unsubstituted residues of LacNAc were found at the apical membranes of a few scattered glandular epithelial cells in normal endometrium, but could be seen more frequently in atrophic, weakly proliferating glandular epithelial cells [ 46 ]. We found no significant intergroup differences in the expression of both terminal and subterminal residues of N-acetyllactosamine, as well as of fucosylated glycans stained with UEA-I; however, similar correlations of the expression of the corresponding glycoconjugates in the studied epithelial compartments of thin and normal endometrium apparently reflect the universal patterns of expression of glycans’ functional residues, common for glycoconjugates of the endometrial glycocalyx, and may feature appropriate changes during the middle secretory phase, which do not affect endometrial receptivity.…”

Section: Discussionmentioning

confidence: 99%

Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

Зиганшина

Долгушина

Kulikova

et al. 2021

Reprod Biol Endocrinol

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Background Low endometrial receptivity is one of the major factors affecting successful implantation in assisted reproductive technologies (ART). Infertile patients with thin endometrium have a significantly lower cumulative clinical pregnancy rate than patients with normal endometrium. Molecular pathophysiology of low receptivity of thin endometrium remains understudied. We have investigated composition of glycocalyx of the apical surface of luminal and glandular epithelial cells in thin endometrium of infertile women. Methods Thirty-two patients with tubal-peritoneal infertility undergoing in vitro fertilization (IVF) were included in the study. Endometrial samples were obtained in a natural menstrual cycle. Patients were divided into two groups: patients with normal endometrium (≥8 mm) and with thin endometrium (< 8 mm). Histochemical and immunohistochemical analysis of paraffin-embedded endometrial samples was performed using six biotinylated lectins (UEA-I, MAL-II, SNA, VVL, ECL, Con A) and anti-LeY and MECA-79 monoclonal antibodies (MAbs). Results Complex glycans analysis taking into account the adjusted specificity of glycan-binding MAbs revealed 1.3 times less expression of MECA-79 glycans on the apical surface of the luminal epithelial cells of thin endometrium compared to normal endometrium; this deficiency may adversely affect implantation, since MECA-79 glycans are a ligand of L-selectin and mediate intercellular interactions. The glycans containing a type-2 unit Galβ1-4GlcNAcβ (LacNAc) but lacking sulfo-residues at 6-OH of GlcNAcβ, and binding to MECA-79 MAbs were found; they can be considered as potential markers of endometrium receptivity. Expression of the lectins-stained glycans on the apical surfaces of the luminal and glandular epithelial cells did not differ significantly. Correlation between the expression of difucosylated oligosaccharide LeY on the apical surfaces of the luminal and glandular epithelial cells was found in patients with thin endometrium and recurrent implantation failure. A similar relationship was shown for mannose-rich glycans. Conclusions Specific features of key glycans expression in epithelial compartments of thin endometrium may be essential for morphogenesis of the endometrial functional layer and explain its low receptivity.

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“…Thus, gastric carcinomas were found to be associated with increased expression of ABH and Le a antigens while colonic cancers were associated with expression of Le b and low expression of the other antigens. In other studies, enhanced fucosyltransferase activity was reported in endometrial cancer leading to unexpected expression of Le a , Le b , and H antigens [37, 38]. …”

Section: Blood Group Disease Associationsmentioning

confidence: 98%

The Role of Red Blood Cells in Enhancing or Preventing HIV Infection and Other Diseases

Motswaledi

Kasvosve

Oguntibeju

2013

BioMed Research International

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Aim. To highlight the apparently neglected role of erythrocyte antigens in the epidemiology of infectious diseases, especially HIV, with the prime objective of stimulating research in this area. Method. A literature search was performed on the PubMed for relevant papers from 1984 to 2013, the era covering active HIV research. This was achieved by using the phrases “erythrocyte blood groups HIV” (81 papers) or “red cell antigen, blood groups, and HIV” (60 papers). A manual Google Scholar search was done and supplemented by original papers referenced by various authors. However, the review was limited by the relative scarcity of papers on the subject, and only papers written in English were reviewed during the period October 2012 to September 2013. Results. Many communicable and noncommunicable diseases are associated with specific blood groups. Examples of these diseases are discussed in detail. HIV has been shown to bind to erythrocytes, and candidate erythrocyte-binding molecules and mechanisms are also discussed. Moreover, erythrocyte-HIV binding is associated with increased viral infectivity, thus, underscoring the need to study this phenomenon and its implications for HIV epidemiology. Conclusion. Erythrocyte antigens may be important in the pathogenesis and epidemiology of many diseases, including HIV.

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N-acetyllactosamine and sialosyl-N-acetyllactosamine in normal and malignant human endometrium

Cited by 4 publications

References 25 publications

Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9.

Clinicopathological Analysis of DU-PAN-2 as a Tumor Marker for Endometrial Adenocarcinoma in Comparison with CA19-9.

Epithelial apical glycosylation changes associated with thin endometrium in women with infertility - a pilot observational study

The Role of Red Blood Cells in Enhancing or Preventing HIV Infection and Other Diseases

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