Immunohistochemical expression of core 2 β1,6‐<i><scp>N</scp></i>‐acetylglucosaminyl transferase 1 (<scp>C</scp>2<scp>G</scp>n<scp>T</scp>1) in endometrioid‐type endometrial carcinoma: a novel potential prognostic factor

Miyamoto, Tsutomu; Suzuki, Asuka; Asaka, Ryoichi; Ishikawa, Kaori; Yumura, Yasushi; Kobara, Hisanori; Nakayama, Jun; Shiozawa, Tanri

doi:10.1111/his.12107

Cited by 12 publications

(7 citation statements)

References 22 publications

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“…Notably, overexpression of GCNT1 has been reported to be associated with progression of prostate cancer (39, 40). Indeed up-regulation of GCNT1 has been reported in many cancer types, including endometrial carcinoma (41), breast cancer (42), bladder cancer (43), testicular germ cell tumor (44), and colorectal and pulmonary carcinoma (45, 46). Transfection of this gene into the GCNT1 -negative prostate carcinoma cell line LNCaP was reported to facilitate adhesion of the cells to type IV collagen and laminin, which may be a factor in aggressive tumor formation (40).…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array

Gao

Liu

Zhang

et al. 2014

Journal of Biological Chemistry

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Background: F77 is a previously uncharacterized prostate cancer-associated antigen.Results: Using a microarray of sequence-defined glycolipids and neoglycolipids, mucin-O-glycan designer arrays, and mass spectrometry, we demonstrate that F77 antibody recognizes blood group H on 6-linked branches of poly-N-acetyllactosamine backbones.Conclusion: F77 antigen is expressed on glycolipids and on glycoprotein O-glycans.Significance: F77 antigen can now be explored rationally as a cancer biomarker.

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Section: Discussionmentioning

confidence: 99%

Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array

Gao

Liu

Zhang

et al. 2014

Journal of Biological Chemistry

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“…A short study (n=84) conducted by Miyamoto et al evaluated C2GnT1 expression using immunohistochemistry in paraffin-embedded endometrial tissues. High C2GnT1 expression correlated with high grade and advanced stage tumors [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

Prognostic molecular biomarkers in endometrial cancer: A review

Hernandez¹,

González-Montiel²,

Allos-Villalva³

et al. 2019

J Cancer Res Ther.

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Background: Endometrial cancer (EC) is the fourth most common malignancy in women worldwide and the most common gynecological cancer in developed countries. The endometrioid subtype has an excellent prognosis with conventional treatment; however, recurrence reduces overall survival. Objective: Describe the most relevant evidence regarding selected potential molecular biomarkers that may predict overall survival (OS), relapse-free survival (RFS), and cancer-specific survival (CSS) in EC. Methods: An exhaustive search was performed in PUBMED with the search terms endometrial cancer, molecular biomarker, and survival. We selected original articles written in English about endometrial cancer, molecular biomarkers, and that included survival analysis published between January 2000 and December 2016. Results: Several molecular prognostic biomarkers have been studied in terms of survival and therapeutic response in women with endometrial cancer; hormone receptors, microRNAs, and other molecules have emerged as potentially useful biomarkers, including HER2, p21, HE4, PTEN, p27, ANCCA, and ANXA2. Conclusions: The use of biomarkers in the assessment of OS, RFS, and CSS requires large trials to expand our understanding of endometrial carcinogenesis. Several molecular markers are significantly associated with a high tumor grade and advanced clinical stage in EC and, therefore, could have additive effects when combined.

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“…Anti‐αGlcNAc (clone HIK1083, mouse IgM) was purchased from Kantokagaku. Rabbit polyclonal antibodies against α4GnT 11 and core 2 β‐1,6‐ N ‐acetylglucosaminyltransferase (C2GnT) 26 were prepared as described previously. Anti‐trefoil factor 2 (TFF2), rabbit polyclonal antibodies, was purchased from Proteintech.…”

Section: Methodsmentioning

confidence: 99%

Glycosylation of MUC6 by α1,4‐linked N‐acetylglucosamine enhances suppression of pancreatic cancer malignancy

et al. 2021

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Immunohistochemical expression of core 2 β1,6‐N‐acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid‐type endometrial carcinoma: a novel potential prognostic factor

Abstract: C2GnT1 appears to be involved in the biological aggressiveness of endometrial carcinoma. C2GnT1 might become a novel prognostic factor for endometrial carcinoma.

Cited by 12 publications

References 22 publications

Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array

Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array

Prognostic molecular biomarkers in endometrial cancer: A review

Glycosylation of MUC6 by α1,4‐linked N‐acetylglucosamine enhances suppression of pancreatic cancer malignancy

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