Two-Year Whey Protein Supplementation Did Not Enhance Muscle Mass and Physical Function in Well-Nourished Healthy Older Postmenopausal Women

Zhu, Kun; Kerr, Deborah A.; Meng, Xingqiong; Devine, Amanda; Solah, Vicky; Binns, Colin; Prince, Richard

doi:10.3945/jn.115.218297

Cited by 84 publications

(95 citation statements)

References 26 publications

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“…Some studies [11, 37, 38] have demonstrated a beneficial effect of nutritional supplementation independent of exercise on muscle strength, physical function, and lean mass in older adults, but others have not [39, 40]. This discrepancy may, in part, be explained by a heterogeneity of response to supplementation in older adults.…”

Section: Discussionmentioning

confidence: 99%

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

et al. 2017

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Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P < 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P < 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training.Trial Registration: ClinicalTrials.gov NCT02281331

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Section: Discussionmentioning

confidence: 99%

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

et al. 2017

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“…After removing duplicates, 1137 identified articles remained of which 1068 were excluded during review of title and abstract (FIGURE 1). Full texts of the remaining 69 articles were obtained and assessed, yielding eight applicable articles for the meta-analysis [11,12,15,16,[21][22][23][24]. In total, we received individual participant data from six articles, which was used for the individual participant data analysis [11,12,15,[21][22][23].…”

Section: Resultsmentioning

confidence: 99%

“…In the pooled dataset (n=486), the mean age at baseline was 74.9 ± 5.1 years and 72.4% (n=352) of the participants was female. Participants in the pooled analysis were healthy (n=282) [11,21,23], sarcopenic (n=78) [22], frail (n=65) [15], diabetic (n=67) [12,22] or had cancer (n=1) [23]. The two studies that were not integrated in the pooled analysis, since we were unable to receive the data, were conducted in healthy females [16] and residential care habitants [24].…”

Section: Participantsmentioning

confidence: 99%

The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: Individual participant data and meta-analysis of RCT's

Tieland

Franssen

Dullemeijer

et al. 2017

The Journal of nutrition, health and aging

110

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“…These observations validated our experimental design to analyze the effect of various protein supplementations in a rodent model of aging. While the rats had free access to food, they were fed with a low-protein standard diet (10% by weight of protein, instead of the normal protein diet at 16%), since previous studies regarding aging have highlighted the ineffectiveness of protein supplementation in subjects who had adequate energy, nutrient, and protein intakes [39–41]. Furthermore, in light of previous reports showing that ingestion of a nutritional supplement immediately after exercise can improve the net protein balance [42, 43], with stimulation of skeletal muscle protein synthesis [44], boluses as free access drinking solution were given immediately following the treadmill sessions.…”

Section: Discussionmentioning

confidence: 99%

Soluble Milk Protein Supplementation with Moderate Physical Activity Improves Locomotion Function in Aging Rats

Lafoux¹,

Baudry²,

Bonhomme³

et al. 2016

PLoS ONE

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Aging is associated with a loss of muscle mass and functional capacity. Present study was designed to compare the impact of specific dairy proteins on muscular function with or without a low-intensity physical activity program on a treadmill in an aged rat model. We investigated the effects of nutritional supplementation, five days a week over a 2-month period with a slow digestible protein, casein or fast digestible proteins, whey or soluble milk protein, on strength and locomotor parameters in sedentary or active aged Wistar RjHan rats (17–19 months of age). An extensive gait analysis was performed before and after protein supplementation. After two months of protein administration and activity program, muscle force was evaluated using a grip test, spontaneous activity using an open-field and muscular mass by specific muscle sampling. When aged rats were supplemented with proteins without exercise, only minor effects of different diets on muscle mass and locomotion were observed: higher muscle mass in the casein group and improvement of stride frequencies with soluble milk protein. By contrast, supplementation with soluble milk protein just after physical activity was more effective at improving overall skeletal muscle function in old rats compared to casein. For active old rats supplemented with soluble milk protein, an increase in locomotor activity in the open field and an enhancement of static and dynamic gait parameters compared to active groups supplemented with casein or whey were observed without any differences in muscle mass and forelimb strength. These results suggest that consumption of soluble milk protein as a bolus immediately after a low intensity physical activity may be a suitable nutritional intervention to prevent decline in locomotion in aged rats and strengthen the interest to analyze the longitudinal aspect of locomotion in aged rodents.

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Two-Year Whey Protein Supplementation Did Not Enhance Muscle Mass and Physical Function in Well-Nourished Healthy Older Postmenopausal Women

Cited by 84 publications

References 26 publications

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial

The impact of dietary protein or amino acid supplementation on muscle mass and strength in elderly people: Individual participant data and meta-analysis of RCT's

Soluble Milk Protein Supplementation with Moderate Physical Activity Improves Locomotion Function in Aging Rats

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