Two‐phase delivery using a horse oil and adenosine‐loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Yang, Hyung Kook; Kim, S.; Jang, Mingyu; Kim, Hyeon-Jun; Lee, Seung‐Hee; Kim, You-Seong; Eom, Younghyon Andrew; Kang, Geonwoo; Chiang, Liching; Baek, Joon Sang; Ryu, Ja Hyun; Lee, Ye Eun; Koh, Jaesuk; Jung, Hyungil

doi:10.1111/jocd.12768

Cited by 23 publications

(16 citation statements)

References 24 publications

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“…In 498 study subjects (87%) the treatment location was on the face, in 46 study subjects (8%) on the extremities and in 27 study subjects (5%) the location was in an easily accessible place for the study person (the chest, arms and shoulder). The preponderance of female patients and face as a region of interest is due to the considerable amount of included studies on facial wrinkle improvement 19–25,27,28,30,32 . In 15 articles, 16,19–28,30–33 hyaluronic acid was utilized as a polymer basis for the DMN.…”

Section: Resultsmentioning

confidence: 99%

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Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review

Decker

Logé

Hoeksema

et al. 2023

The Journal of Dermatology

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Intra-and transdermal drug delivery via the skin offers a non-to minimally-invasive, effective, and patient-compliant method for administrating substances such as medication or vaccines. 1-3 Intra-and transdermal delivery is considered profoundly safe, maintains a steady plasma concentration and avoids the significant hepatic first-pass metabolism effect which limits the biological availability in enteral administration. [1][2][3][4] Parenteral administration via cutaneous penetration is considered to be painful and when done frequently harbors the risk of infection, is inconvenient, and reduces patient compliance. 2,5,6 Topical

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Section: Resultsmentioning

confidence: 99%

“…Yang et al 32 compared DMN loaded with horse oil and Ad to Ad‐loaded DMN (HOS‐Ad‐DMN & Ad‐DMN, respectively). The research group found an improvement in skin elasticity, skin hydration, average and maximum depth of wrinkles in both groups after 8 weeks of treatment compared to baseline.…”

Section: Resultsmentioning

confidence: 99%

Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review

Decker

Logé

Hoeksema

et al. 2023

The Journal of Dermatology

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“…Results obtained showed that Ado was delivered via the horse DMNs (HOS‐Ado‐DMN) after skin penetration and horse oil was delivered into the skin through the microchannels created by the Ado‐DMNs. This formulation was compared with Ado‐DMN patches and results revealed that there is significantly improved skin elasticity, hydration, dermal density, and wrinkles with HOS‐Ado‐DMN without adverse effects 66 …”

Section: Ado Formulationsmentioning

confidence: 99%

“…This formulation was compared with Ado‐DMN patches and results revealed that there is significantly improved skin elasticity, hydration, dermal density, and wrinkles with HOS‐Ado‐DMN without adverse effects. 66 …”

Section: Ado Formulationsmentioning

confidence: 99%

The possible role of the nucleoside adenosine in countering skin aging: A review

et al. 2022

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Skin aging is a complex biological process. Skin aspect is considered as a sign of well‐being and of beauty. In view of this, noninvasive and/or minimally invasive anti‐aging strategies were developed. Adenosine, a well‐known nucleoside, may play a role in skin rejuvenation. Adenosine receptors belong to the G protein‐coupled receptors superfamily and are divided into four subtypes: A1, A2A, A2B, and A3. The adenosine receptors expressed by skin are mainly the A1 and A2A subtypes. In the hypodermis, adenosine through the A1 receptor stimulates lipogenesis and adipogenesis. In the dermis, adenosine through the A2A receptor subtype stimulates collagen production. Moreover, the nucleoside increases new DNA synthesis and subsequently protein synthesis in dermal cells. Activation of adenosine receptors by interacting with various skin layers may induce a decrease in the amount of wrinkles, roughness, dryness, and laxity. This article has reviewed the mechanisms through which adenosine modulates biological mechanisms in the skin tissues and the effect of preparations containing adenosine or its derivatives on the skin.

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“…Combined approaches have led to improved transdermal delivery and efficacy compared to the individual applications of DMN or topical formulations. Another study reported the use of a two-phase (hydrophilic and lipophilic phase) delivery system consisting of a DMN patch (containing adenosine) and horse oil spread on the edge of the patch [15]. The oil phase was delivered into the skin through the channels created by the DMNs, and adenosine, a hydrophilic drug loaded within the DMNs, was delivered.…”

Section: Introductionmentioning

confidence: 99%

A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery

Song¹,

Jun²,

Park³

et al. 2020

Polymers

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Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective transdermal drug delivery without loading drugs themselves by introducing TEMPO-oxidized bacterial cellulose nanofibers (TOBCNs), which are well dispersed, while retaining their unique properties in the aqueous phase. The SDMN patch fabricated by the micro-molding of a TOBCN/hydrophilic biopolymer mixture had a two-layer structure comprising a water-soluble needle layer and a TOBCN-containing insoluble backing layer. Moreover, the SDMN patch, which had a hole in the backing layer where TOBCNs are distributed uniformly, could offer novel advantages for the delivery of large quantities of active ingredients. In vitro permeation analysis confirmed that TOBCNs with high water absorption capacity could serve as drug reservoirs. Upon SDMN insertion and the application of drug aqueous solution through the drug inlet hole, the TOBCNs rapidly absorbed the solution and supplied it to the needle layer. Simultaneously, the needle layer dissolved in body fluids and the drug solution to form micro-channels, which enabled the delivery of larger quantities of drugs to the skin compared to that enabled by solution application alone.

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Two‐phase delivery using a horse oil and adenosine‐loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

Abstract: HOS-Ad-DMN patches are a safe and efficient system for skin restoration and wrinkle improvement.

Cited by 23 publications

References 24 publications

Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review

Dissolving microneedles for effective and painless intradermal drug delivery in various skin conditions: A systematic review

The possible role of the nucleoside adenosine in countering skin aging: A review

A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery

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