Two novel classification systems for uterine fibroids and subsequent uterine reconstruction after myomectomy

Juhasz-Böss, Ingolf; Jungmann, Peter; Radosa, Julia Caroline; Heesen, Anika von; Ströder, Russalina; Juhasz-Böss, S; Meyberg-Solomayer, G; Solomayer, Erich

doi:10.1007/s00404-016-4268-6

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…The differentiation between benign and malignant myometrial lesions continues to present a considerable challenge for pathologists, and sometimes the final diagnosis remains inconclusive [22,48]. A number of criteria have been suggested in an attempt to unify the classification of the uterine tumors [22,48,49,50]. Based on tumor morphology and biology, four groups of myometrial tumors have been distinguished [51].…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

Rubisz

Ciebiera

Hirnle

et al. 2019

IJMS

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Uterine leiomyomas (LMs), currently the most common gynecological complaint around the world, are a serious medical, social and economic problem. Accurate diagnosis is the necessary prerequisite of the diagnostic-therapeutic process. Statistically, mistakes may occur more often in case of disease entities with high prevalence rates. Histopathology, based on increasingly advanced immunohistochemistry methods, is routinely used in the diagnosis of neoplastic diseases. Markers of the highest sensitivity and specificity profiles are used in the process. As far as LMs are concerned, the crux of the matter is to identify patients with seemingly benign lesions which turn out to be suspicious (e.g., atypical LM) or malignant (e.g., leiomyosarcoma (LMS)), which is not uncommon. In this study, we present the current state of knowledge about the use of immunohistochemical markers in the differential diagnosis of LM, atypical LM, smooth muscle tumors of uncertain malignant potential (STUMP), and LMS, as well as their clinical predictive value.

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Section: Introductionmentioning

confidence: 99%

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

Rubisz

Ciebiera

Hirnle

et al. 2019

IJMS

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“…Uterine fibroids are common benign tumors among women of reproductive age that impair their health and quality of life [1]. The prevalence of uterine fibroids increases with age, and they may be present in over 70% of the premenopausal population [2,3].…”

Section: Introductionmentioning

confidence: 99%

MRI evaluation of endopelvic fascial swelling and analysis of influencing factors in patients with uterine fibroids after high-intensity focused ultrasound ablation

Zhang

Xiao

Sheng

et al. 2020

International Journal of Hyperthermia

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“…Uterine leiomyoma is among the most frequent entities encountered in the practice of gynecology by the age of 50 [14]. There are three types of leiomyomas: intramural (most common), subserosal and submucosal leiomyomas [32,33]. In this study, intramural tumors were the most common type observed, followed by subserosal tumors.…”

Section: Discussionmentioning

confidence: 50%

Assessing the role of serum prolactin levels and coding region somatic mutations of the prolactin gene in Saudi uterine leiomyoma patients

et al. 2020

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Introduction: Uterine leiomyomas (UL) are highly prevalent benign smooth muscle tumors, seen in approximately 70% of women. These hormone responsive tumors are also known to secrete prolactin (PRL), a hormone of the anterior pituitary gland. Elevated levels of serum prolactin are a common clinical finding in different gynecological pathologies including UL. However, the underlying causes for this elevation are not yet clear. Therefore, the main objective of this study is to measure the serum PRL in UL patients and also to investigate its molecular connection with coding region somatic mutations of the PRL gene. Material and methods: The serum PRL levels of UL patients were measured through the ELISA method. The coding region PRL gene mutations in UL and corresponding myometrium tissues were screened through the Sanger sequencing method. Results: Uterine leiomyoma patients demonstrated significant elevation of the PRL hormone level in serum samples (p ≤ 0.01). No somatic coding region mutations in the PRL gene were identified. However, four germline variants (c.570G>A, c.205-102T>A, c.312+177T>C and c.269C>T) were detected. Conclusions: This study is the first one to confirm that serum PRL level elevation among UL patients is not connected to somatic mutations in the PRL gene. However, PRL genetic polymorphisms may indirectly contribute to the disease etiology.

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Two novel classification systems for uterine fibroids and subsequent uterine reconstruction after myomectomy

Cited by 10 publications

References 10 publications

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

MRI evaluation of endopelvic fascial swelling and analysis of influencing factors in patients with uterine fibroids after high-intensity focused ultrasound ablation

Assessing the role of serum prolactin levels and coding region somatic mutations of the prolactin gene in Saudi uterine leiomyoma patients

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