The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

Rubisz, Piotr; Ciebiera, Michał; Hirnle, Lidia; Zgliczyńska, Magdalena; Łoziński, Tomasz; Dzięgiel, Piotr; Kobierzycki, Christopher

doi:10.3390/ijms20051136

Cited by 44 publications

(60 citation statements)

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“…Uterine fibroid (UF) is the most common benign tumor occurring in women of reproductive age. The name reflects its hard and fibrous consistency, in addition to its characteristic microscopic presentation [1,2]. UF represents a localized proliferation of myometrial smooth muscle cells surrounded by a pseudocapsule of compressed muscle fibers.…”

Section: Uterine Fibroids: Epidemiology and Symptomatologymentioning

confidence: 99%

“…The use of NAMPT [80] (e.g., in the differentiation of tumors such as UFs and LMS) is another interesting issue which is also indirectly related to vitamin B3 and UFs. Although there has been considerable progress in the differentiation of such pathologies, some lesions are still very difficult to distinguish [2,197]. It is possible that the use of such new markers could help in the effective differentiation of lesions, which would provide the patient with the selection of a suitable therapy.…”

Section: New Trends and Possible Future Role Of Vitamins In Uterine Fmentioning

confidence: 99%

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Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Ciebiera

Ali

Zgliczyńska

et al. 2020

IJMS

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Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology.

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Section: Uterine Fibroids: Epidemiology and Symptomatologymentioning

confidence: 99%

Section: New Trends and Possible Future Role Of Vitamins In Uterine Fmentioning

confidence: 99%

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Ciebiera

Ali

Zgliczyńska

et al. 2020

IJMS

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“…According to various data their prevalence may reach up to 70-80% in predisposed groups of women, but the frequency of the detection depends on selected diagnostic methods [3,4]. The risk factors for the UF's development include some modifiable and non-modifiable factors [3,5]. According to recent data, the most important ones are: race, age, premenopausal state, hypertension, positive family history, time since last birth and food additives [3].…”

Section: Uterine Fibroids-overviewmentioning

confidence: 99%

The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside

Ciebiera

Włodarczyk

Zgliczyński

et al. 2020

IJMS

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Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30–40%, but may reach up to 70–80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major reason of the overall deterioration of the quality of life. The mechanisms leading to UFs formation and growth still remain poorly understood. The transformation of smooth muscle cells of the uterus into abnormal, immortal cells, capable of clonal division, is thought to be a starting point of all pathways leading to UF formation. Micro-ribonucleic acids (miRNAs) are non-coding single-stranded RNAs about 22 nucleotides in length, that regulate gene expression. One of recent advances in this field is the comprehension of the role of miRNAs in tumorigenesis. Alterations in the levels of miRNAs are related to the formation and growth of several tumors which show a distinct miRNA signature. The aim of this review is to summarize the current data about the role of miRNAs in the pathophysiology of UFs. We also discuss future directions in the miRNA research area with an emphasis on novel diagnostic opportunities or patient-tailored therapies. In our opinion data concerning the regulation of miRNA and its gene targets in the UFs are still insufficient in comparison with gynecological malignancies. The potential translational use of miRNA and derived technologies in the clinical care is at the early phase and needs far more evidence. However, it is one of the main areas of interest for the future as the use of miRNAs in the diagnostics and treatment of UFs is a new and exciting opportunity.

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“…Diagnostics 2020, 10, x FOR PEER REVIEW 2 of 8 most PEComas have a morphologically distinctive capillary architecture, further studies need to characterize these non-myometrial tumors [2]. One of the most common primary sites for PEComas is the female genitourinary tract, and the uterus is the most involved site after the kidney [3].…”

Section: Case Presentationmentioning

confidence: 99%

“…They have a perivascular distribution and express both melanocytic and smooth muscle markers [1]. Although most PEComas have a morphologically distinctive capillary architecture, further studies need to characterize these non-myometrial tumors [2].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Features of a Uterine Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review

et al. 2020

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Background: Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors. One of the most frequent localizations of PEComas is the female genitourinary tract, and the uterus is the most involved site after the kidney. Correct preoperative diagnosis is rarely achieved due to the presence of nonspecific imaging features. We report a case of a uterine PEComa with particular reference to ultrasound’s role in characterizing this rare occurrence. Case presentation: a 45-year-old White woman came to our observation for cyclic abdominopelvic pain and chronic constipation. The pre-surgical ultrasound examination showed a heterogeneous tumor that was 4 cm in size, localized on the right anterolateral uterine wall. The mass had well-delimited borders and a central hypoechoic portion. The use of color Doppler showed a rich, irregular vasculature in the center with low impedance. The preoperative diagnostic hypothesis was of a smooth muscle tumor of uncertain malignant potential. After careful counseling, a surgical approach was decided upon, including a total laparoscopic hysterectomy with bilateral salpingectomy. The histological and phenotypical features were consistent with a uterine PEComa. At the last follow-up, two years after surgery, the patient is alive and well. Conclusions: Uterine PEComa is a rare occurrence that should be included in the differential diagnosis of uterine wall tumors. It can appear as a small uterine mass with heterogeneous echogenicity and a rich vascular pattern during an ultrasound evaluation. This diagnostic suspicion may assist in better surgical planning.

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The Usefulness of Immunohistochemistry in the Differential Diagnosis of Lesions Originating from the Myometrium

Cited by 44 publications

References 146 publications

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance

The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside

Ultrasound Features of a Uterine Perivascular Epithelioid Cell Tumor (PEComa): Case Report and Literature Review

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