Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Kaennakam, Sutin; Mudsing, Kamonwan; Rassamee, Kitiya; Siripong, Pongpun; Tip‐pyang, Santi

doi:10.1007/s11418-018-1240-8

Cited by 17 publications

(8 citation statements)

References 14 publications

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“…EtOAc fractions from methanolic extracts of leaves and stems had the most active DPPH antioxidant activity and were shown to be more effective than the Trolox positive control. The ranges of antioxidant capacity obtained are within similar ranges to other species of the same family, both for DPPH and ABTS [28][29][30][31] . Likewise, F-EtOAc leaf fractions had α-glucosidase inhibitory activity, similar to other species in the Clusiaceae family 29,[32][33][34] .…”

Section: Discussionsupporting

confidence: 70%

The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts

Silva-Rivas¹,

Bailón-Moscoso²,

Cartuche³

et al. 2020

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Introduction: The prevalence of diabetes has increased more rapidly in low and middleincome countries than in high-income countries. Type 2 diabetes mellitus (DM2), which is the most common form of diabetes, is caused by the inefficient use of insulin in the body and is characterized by disrupted insulin action or secretion. Also, oxidative stress plays an important role in the development of disease. The goal of this study is to identify the antioxidant and hypoglycemic properties of Clusia latipes, an endemic species of Central and South America. Methods: The antioxidant and hypoglycemic capacity of the extracts (hexane, ethyl acetate, and methanol) of the leaves and stems of Clusia latipes were evaluated. From the most potent extract, the phytochemical study was carried out and fractionated. Antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), while hypoglycemic capacity was measured by alpha-glucosidase inhibition. Results: The extracts with the highest antioxidant capacity are the extracts with the highest α-glucosidase inhibition activity. Inhibitory activity increased in samples extracted with medium polar (ethyl acetate) and polar (methanol) solvents. Phytochemical screening of these extracts revealed the presence of alkaloids, carbohydrates, flavonoids/xanthones, quinones, saponins, and tannins. The highest α-glucosidase inhibitory activity was detected in the ethyl acetate fraction obtained from leaf methanol extract, with a half-maximal inhibitory concentration (IC 50 ) value of 0.90 μg/ml. The major constituent isolated from the same fraction was isoquercitrin.

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Section: Discussionsupporting

confidence: 70%

The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts

Silva-Rivas¹,

Bailón-Moscoso²,

Cartuche³

et al. 2020

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“…In 2019, Kaennakam et al reported the isolation of two new xanthones, i.e., schomburgones A and B from the bark of Garcinia schomburgkiana. Unfortunately, these compounds are nonactive against HepG2, MCF-7, HT-29, HeLa S-3, and KB cancer cells, with IC 50 values of 45.05-69.22 µM [68].…”

Section: Isolation Of Xanthone Derivativesmentioning

confidence: 99%

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

et al. 2021

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The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.

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“…Unauthorized distribution is strictly prohibited. oxyguttiferone K (9) [16], oblongifolin G (10) [17]. The chemical structures of the known compounds were confirmed by NMR spectroscopic data and comparison with previously published data.…”

Section: Accepted Manuscriptmentioning

confidence: 84%

“…Five undescribed polyprenylated benzoylphloroglucinol derivatives (1)(2)(3)(4)(5), named garschomcinols A-E, and five known analogues (6)(7)(8)(9)(10) were isolated from the branches of Garcinia schomburgkiana. Their structures were determined on the basis of 1D and 2D NMR and HRESIMS analyses.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives from the Branches of Garcinia schomburgkiana

et al. 2022

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Five undescribed polyprenylated benzoylphloroglucinol derivatives (1‒5), named garschomcinols A‒E and five known analogues (6‒10) were isolated from the branches of Garcinia schomburgkiana. Their structures were determined on the basis of 1D and 2D NMR and HRESIMS analyses. The absolute configuration of the bicyclo[3.3.1]nonane core structure of the polyprenylated benzoylphloroglucinols were assigned by comparison of their experimental ECD data with those of related compounds. All isolated compounds were evaluated for their cytotoxicity in vitro against five cancer cell lines. Compound 6 showed potent cytotoxicity against five cancer cell lines including KB, HeLa S3, HT-29, MCF-7, and Hep G2 with IC50 values in the range of 5.05‒7.03 µM.

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Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Cited by 17 publications

References 14 publications

The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts

The Antioxidant and Hypoglycemic Properties and Phytochemical Profile of Clusia latipes Extracts

An Update on the Anticancer Activity of Xanthone Derivatives: A Review

Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives from the Branches of Garcinia schomburgkiana

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