Two new stereoisomeric antioxidant triterpenes from Potentilla fulgens

Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P. speciosa L. and P. reptans Willd.) and Their Chemical Composition

“…Besides, Liu et al (2016) reported that the ABTS values of P. fruticosa varied from 303 to 1309 μmol TE/g. In addition, researchers have reported that different Potentilla species have important radical scavenging activities (Choudhary et al, 2013; Rauf et al, 2013; Wang et al, 2013). …”

“…Several classes of natural compounds found in Potentilla species could be responsible for their antiproliferative activity. Previous studies revealed that triterpenoids, tannins and phenolic compounds isolated from Potentilla species exhibited cytotoxic activities against some human cancer cell lines (Li et al, 2007; Tomczyk and Latté, 2009; Choudhary et al, 2013; Rauf et al, 2015). For example two flavonoids (such as chrysin) from P. evestita Th.Wolf showed prominent cytotoxic and antitumor promoting properties (Rauf et al, 2015).…”

Qualitative and Quantitative Analysis of Potentilla fulgens Roots by NMR, Matrix‐assisted Laser Desorption/Ionisation with Time‐of‐Flight MS, Electrospray Ionisation MS/MS and HPLC/UV

“…Markers used for quantitative analysis, that is, catechin ( 1 ), epicatechin ( 5 ), afzelechin ( 7 ), epiafzelechin ( 8 ), catechin (4 α → 8) epicatechin ( 2 ), afzelechin (4 α → 8) catechin ( 3 ), afzelechin (4 β → 8) epicatechin ( 4 ), afzelechin (4 α → 8) epiafzelechin ( 6 ) and epiafzelechin (4 β → 8) epicatechin ( 9 ) were isolated by semi‐preparative HPLC (as described below) from the roots of P. fulgens and characterised by 1 H‐NMR, 13 C‐NMR, two‐dimensional NMR techniques and ESI/HRMS (see Figs S16–S36 in the on‐line Supporting information), as well as by comparison with literature data (Hsu et al ., ; Kashiwada et al ., ; Wan and Chan, ; Ali et al ., ; Ushirobira et al ., ; Ragab et al ., ). Isolation and characterisation of euscaphic acid ( 10 ), fulgic acid A ( 11 ), fulgic acid B ( 12 ), ursolic acid ( 13 ) and corosolic acid ( 14 ) has been described previously (Choudhary et al ., ). The ESI/HRMS data were recorded on Maxis™ ultrahigh resolution TOF (Bruker, Bremen, Germany).…”

“…In recent years, various pharmacological studies conducted on the extracts of this plant have supported its ethnomedical use. The plant extracts have been reported to possess anti-diabetic (Syiem et al, 2002;Syiem and Majaw, 2010), anti-cancer (Radhika et al, 2012), anthelminthic (Roy et al, 2010), gastro-protective (Laloo et al, 2013) and anti-oxidant properties (Choudhary et al, 2013). The plants of this genus have been shown to be rich in triterpenes and polyphenols (Tomczyk and Latte, 2009;Jaitak et al, 2010aJaitak et al, ,2010bKumar et al, 2013).…”

Anticariogenic potential of <em>Potentilla fulgens</em> extract and its chemical constituents

“…Recently, a few reports on its cancer preventing and anti-diabetic properties have been documented [16][17]. We have earlier described isolation and structure elucidation of two new triterpene compounds along with several flavan-3-ol type of compounds from roots of Potentilla fulgens [18,19]. In continuation of the phytochemical investigations and recognizing the role of polyphenols in dental caries management, we planned to undertake extensive studies to evaluate anticariogenic effects of the plant and search for anticariogenic phenolic molecules.…”