Qualitative and Quantitative Analysis of <i>Potentilla fulgens</i> Roots by NMR, Matrix‐assisted Laser Desorption/Ionisation with Time‐of‐Flight MS, Electrospray Ionisation MS/MS and HPLC/UV

Choudhary, Alka; Manukonda, Radhika; Chatterjee, Anupam; Banerjee, Uttam Chand; Singh, Inder Pal

doi:10.1002/pca.2547

Cited by 21 publications

(20 citation statements)

References 24 publications

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“…15 Qualitative and quantitative analysis of P. fulgens roots by nuclear magnetic resonance spectroscopy, matrix-assisted laser desorption/ionization with time-of-flight mass spectrometry (MS), electrospray ionization MS/MS and high-performance liquid chromatography/ultraviolet have also been reported. 16 Phytochemical investigations of the root parts of P. fulgens have shown the presence of a novel bioflavonoid potifulgene along with epicatechin. 17 It has also been reported that the aerial parts contain two new triterpenes, potentene-A and potentene-B, as well as three known compounds, afzelchin-4 α!8″ catechin, epiafzelechin, and rutin.…”

Section: Introductionmentioning

confidence: 99%

Effect of Potentilla Fulgens L. on Selected Enzyme Activities and Altered Tissue Morphology in Diabetic Mice

2018

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Introduction The objective of the present study was to investigate the in vitro inhibitory effect of the Potentilla fulgens extract on amylase, α- and β-glucosidase, and lipase, as well as its effect on the ultrastructure of the liver, of the kidneys, and of the eye tissues in alloxan-induced diabetic mice. The present study was designed to get further insight regarding the action of P. fulgens from what has been previously known and reported about this plant. Materials and Methods Roots of P. fulgens were extracted with 10 volumes of aqueous-methanol solution (1:4), and the prepared extract was used for in vitro inhibitory activity on amylase, α-glucosidase, β-glucosidase, and lipase. Afterwards, the plant extract was intraperitoneally administered for alternated days (250 mg/kg body weight) to diabetic mice for 4 weeks, and an ultrastructural examination of the liver, the kidneys and the eye tissues was performed using a transmission electron microscope (JEM-100 CX II, Jeol Ltd., Tokyo Japan). Results The P. fulgens extract showed inhibitory activity against all the four enzymes (amylase, α- and β-glucosidase, and lipase), with the highest percentage of inhibition (94.57% ± 0.16 at 1 mg/mL) being observed against α-glucosidase when compared with the standard. The ultrastructural studies revealed a distortion in the structure of the nuclei and of the mitochondria in the kidneys and liver tissues of diabetic mice. Distortion of cell shape and disturbed orientation was observed in the eye lens of diabetic mice. The P. fulgens extract reversed/protected/reduced the ultrastructural alteration observed in the tissues (liver, kidney, and eye lens) of diabetic mice. Conclusion The inhibitory effect of the P. fulgens extract against the aforementioned enzymes and its protective effect on the tissues of diabetic mice against alloxan-induced diabetes add further insight into the antidiabetic properties of this plant.

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Section: Introductionmentioning

confidence: 99%

Effect of Potentilla Fulgens L. on Selected Enzyme Activities and Altered Tissue Morphology in Diabetic Mice

2018

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“…Several flavanols and triterpenes have been estimated in the crude extract by HPLC-UV method. Ursolic acid (0.82 ± 0.05 %) and epicatechin (0.67 ± 0.03 %) were found to be the major compounds in the tested sample of roots [19]. Antibacterial assay by agar diffusion method…”

Section: Standardization Of Extractmentioning

confidence: 99%

“…Recently, a few reports on its cancer preventing and anti-diabetic properties have been documented [16][17]. We have earlier described isolation and structure elucidation of two new triterpene compounds along with several flavan-3-ol type of compounds from roots of Potentilla fulgens [18,19]. In continuation of the phytochemical investigations and recognizing the role of polyphenols in dental caries management, we planned to undertake extensive studies to evaluate anticariogenic effects of the plant and search for anticariogenic phenolic molecules.…”

Section: Introductionmentioning

confidence: 99%

Anticariogenic potential of <em>Potentilla fulgens</em> extract and its chemical constituents

Choudhary¹,

Bihade²,

Mittal³

et al. 2017

ijpm

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“…Phenolic compounds, quercetin, ellagic acid and kaempferol were reported for the first time in n-butanol fraction of P. fulgens , acts as potential antioxidative and cancer chemopreventive agents [31].…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

Potentilla fulgens: A Systematic Review on Traditional Uses, Pharmacology and Phytochemical Study with Reference to Anticancer Activity

Barua¹,

Yasmin²

2018

JNPR

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Potentilla fulgens has been extensively used in folk medicine by the local people of Meghalaya in North East India. Traditionally, the root-stock and the whole plant, Potentilla fulgens are utilized as astringent and tonic for curing the gums from tooth ailments. The aqueous root peel extract of this plant is consumed to get rid of intestinal infections and also the tap root is traditionally chewed along with betel nut (Areca catechu) and betel leaves (Piper betel) for various ailments. North East India has maximum incidence and occurrence of different types of oral cancer due to consumption of tobacco, tobacco related compounds and alcohol. Taking into consideration its high medicinal value and popularity of the plant, we have tried to compile and update the latest research work carried out by other workers and to explore its potential as anticancer therapy with a futuristic approach. Subsequently, the plant has been studied in detail on its various pharmacological activity by few researchers and two reviews were already published in the years 2009 and 2011, encompassing its pharmacological, taxonomical, phytochemical attributes. So, our aim was to explore the latest work done so far post 2011.

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Qualitative and Quantitative Analysis of Potentilla fulgens Roots by NMR, Matrix‐assisted Laser Desorption/Ionisation with Time‐of‐Flight MS, Electrospray Ionisation MS/MS and HPLC/UV

Abstract: It is evident from these analyses that roots of P. fulgens contain flavans, including oligomeric flavanols, as major constituents followed by triterpene acids. The methods described can be applied to other Potentilla species to identify their constituents.

Cited by 21 publications

References 24 publications

Effect of Potentilla Fulgens L. on Selected Enzyme Activities and Altered Tissue Morphology in Diabetic Mice

Effect of Potentilla Fulgens L. on Selected Enzyme Activities and Altered Tissue Morphology in Diabetic Mice

Anticariogenic potential of <em>Potentilla fulgens</em> extract and its chemical constituents

Potentilla fulgens: A Systematic Review on Traditional Uses, Pharmacology and Phytochemical Study with Reference to Anticancer Activity

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