2007
DOI: 10.1002/chin.200703169
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Two New Sesquiterpene Lactones from the Leaves of Laurus nobilis

Abstract: Laurus nobilis L. (Lauraceae) is an evergreen tree widespread in the Mediterranean area and Europe, and as a folk medicine, the decoction or tea of bay leaves is often used as a carminative, intestinal and gastric antispasmodic, against diarrhea , for rheumatic pains, in diseases of the respiratory tract, as a cough sedative, to treat asthma and cardiac diseases , 1-3) and in cases of dysmenorrhea (pers. comm.). Previous phytochemical investigations have led to the isolation of several classes of secondary met… Show more

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Cited by 7 publications
(13 citation statements)
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“…The anticancer activities of these extracts have driven the bioactivity-guided isolation of the responsible active compounds. Thus, lauroside B (76), a megastigmane glycoside from a methanolic extract of laurel leaves [211]; kaempferol-3-O-pcoumarate (134), a flavonoid from an ethyl acetate extract of laurel leaves [85]; costunolide (16), santamarine (28), reynosin (31), 11,13-dehydrosantonin (42), gazaniolide (45), spirafolide (48), and lauroxepine (65), sesquiterpenoids from a methanolic extract of laurel fruits [39]; anhydroperoxycostunolide (21) and 3-oxoeudesma-1,4(15),11(13)triene-12,6α-olide (43), sesquiterpenoids from a hot water extract of laurel leaves [94]; dehydrocostus lactone (22) and 3-chlorodehydrocostus lactone (25), sesquiterpenoids from a petroleum ether extract of laurel leaves [50]; costunolide (16), dehydrocostus lactone (22), 3-chlorodehydrocostus lactone (25), and lactone 49, sesquiterpenoids from a chloroform extract of laurel leaves [50,207]; lucentolide (20), anhydroperoxycostunolide (21), santamarine (28), reynosin (31), hydroperoxide-magnolialide (32), magnolialide (35), 3-peroxyarmefolin (36), 11,13dehydrosantonin (42), tubiferin (44), some more eudesmane lactones (30, 33, 34, 37, 38, 47), and several -hydroxyesters (60-64), all sesquiterpenoids from a dichloromethane extract of laurel leaves [52], have been isolated as the active compounds.…”
Section: Review On Laurus Nobilismentioning
confidence: 99%
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“…The anticancer activities of these extracts have driven the bioactivity-guided isolation of the responsible active compounds. Thus, lauroside B (76), a megastigmane glycoside from a methanolic extract of laurel leaves [211]; kaempferol-3-O-pcoumarate (134), a flavonoid from an ethyl acetate extract of laurel leaves [85]; costunolide (16), santamarine (28), reynosin (31), 11,13-dehydrosantonin (42), gazaniolide (45), spirafolide (48), and lauroxepine (65), sesquiterpenoids from a methanolic extract of laurel fruits [39]; anhydroperoxycostunolide (21) and 3-oxoeudesma-1,4(15),11(13)triene-12,6α-olide (43), sesquiterpenoids from a hot water extract of laurel leaves [94]; dehydrocostus lactone (22) and 3-chlorodehydrocostus lactone (25), sesquiterpenoids from a petroleum ether extract of laurel leaves [50]; costunolide (16), dehydrocostus lactone (22), 3-chlorodehydrocostus lactone (25), and lactone 49, sesquiterpenoids from a chloroform extract of laurel leaves [50,207]; lucentolide (20), anhydroperoxycostunolide (21), santamarine (28), reynosin (31), hydroperoxide-magnolialide (32), magnolialide (35), 3-peroxyarmefolin (36), 11,13dehydrosantonin (42), tubiferin (44), some more eudesmane lactones (30, 33, 34, 37, 38, 47), and several -hydroxyesters (60-64), all sesquiterpenoids from a dichloromethane extract of laurel leaves [52], have been isolated as the active compounds.…”
Section: Review On Laurus Nobilismentioning
confidence: 99%
“…Sesquiterpenoids: It was reported in 1971 [35] the isolation from laurel roots of the first sesquiterpene lactone: laurenobiolide (11). Since then, ten more lactones with a germacrane skeleton (12)(13)(14)(15)(16)(17)(18)(19)(20)(21) have been isolated from roots [36,37], fruits [38,39] and leaves [37,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] (Figure 4). Dehydrocostus lactone (22), zaluzanin D (24) and eremanthin (26) were the first lactones isolated from laurel with a guaiane skeleton [38], and santamarine (28) and reynosin (31) the first ones with a eudesmane skeleton [40].…”
mentioning
confidence: 99%
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“…Laurus nobilis (Lauraceae), one of the main sources of plant volatile oils, is an evergreen shrub that can grow up to 8 meters tall. It has dark green leaves about 8-14 cm long and 3-4 cm wide [12,13].…”
Section: Introductionmentioning
confidence: 99%