Two New Prenylated Xanthones from the Bark of Garcinia xanthochymus

Chen, Yu; Yang, Guangzhong; Zhong, Fangfang; He, Hongwu

doi:10.5012/bkcs.2010.31.11.3418

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…The five known xanthones isolated from G. xanthochymus bark in this study were identified as symphoxanthone ( 2 ) [15], jacarelhyperols B ( 3 ) [16,17,18], garcinenones Y ( 4 ) [19], 3,4-dihydro-3,6,7,11-tetrahydroxy-8,9-di-(3-methyl-2-butenyl)-2,2-dimenthyl-pyrano-[2,3-c]xanthone ( 5 ) [20], and 7-geranyl-1,3,5,6-tetrahydroxy-8-(3-menthyl-2-butenyl)xanthone ( 6 ) [14] through comparison of the spectroscopic data with the literature. The NMR spectrum map of the known compounds was shown in Supplementary Materials Figures S5–S30.…”

Section: Resultsmentioning

confidence: 99%

Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway

Jin

Shi

Liu

et al. 2019

IJMS

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Xanthones are important chemical constituents of Garcinia xanthochymus and varied bioactivities including cytotoxicity. However, their anti-tumor mechanism has remained unknown. Here, we isolated and identified a new xanthone named garciniaxanthone I (1) and five known compounds from the bark of G. xanthochymus. Their structures were elucidated by NMR analysis and HRESIMS. The anti-proliferation activities of all isolated compounds were evaluated on four human tumor cell lines (HepG2, A549, SGC7901, MCF-7). The results demonstrated that the anti-proliferation activity of xanthone was related to the number and location of prenyl groups. We further found that garciniaxanthone I (GXI) could induce HepG2 apoptosis and enhance the expression of cleaved caspase-8, caspase-9, and caspase-3. GXI could also increase Bax level and concurrently reduce the overexpression of Bcl-2, Bcl-XL, Mcl-1, and surviving in HepG2 cells. Moreover, GXI could inhibit cell migration of HepG2 cells by inhibiting the expressions of MMP-7 and MMP-9. In summary, our study suggests that GXI could induce HepG2 apoptosis via the mitochondrial pathway and might become a lead compound for liver cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway

Jin

Shi

Liu

et al. 2019

IJMS

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“…Besides, the fruits and leaves of G. xanthochymus are edible and usually eaten by local people. The phytochemical and pharmacological studies reveal that it is a rich resource of polyphenols with antioxidant and anti-diabetic activities [16][17][18][19][20]. Most of these components present in the extract are antioxidants endowed with reducing property.…”

Section: Introductionmentioning

confidence: 99%