Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway

Jin, Shuai; Shi, Kuan; Liu, Liu; Chen, Yu; Yang, Guangzhong

doi:10.3390/ijms20194803

Cited by 15 publications

(14 citation statements)

References 33 publications

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“…In our previous studies, series of PPAPs and xanthones isolated from the barks and fruits of G. xanthochymus exhibited good antitumor activities [ 20 , 21 , 22 ]. To explore more functional chemical constituents as novel tools for cancer therapy, we isolated and identified six new PPAPs together with nine known compounds from the edible fruits of G. xanthochymus .…”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel Polycyclic Polyprenylated Acylphloroglucinols from the Fruits of Garcinia xanthochymus as Antitumor Agents by Suppressing the STAT3 Signaling

Jin

Wang

Gan

et al. 2021

IJMS

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Pharmacologic studies have revealed that polycyclic polyprenylated acylphloroglucinols (PPAPs) collectively exhibit a broad range of biological activities, including antineoplastic potential. Here, six new PPAPs, named garcixanthochymones F–K (3, 5, 7, 8, 11, and 15), together with nine known analogues were isolated from the fruits of Garcinia xanthochymus. Their structures were elucidated based on the spectroscopic data, including UV, HRESIMS, and NMR, and quantum chemical calculations. All the isolated PPAPs were tested for anti-proliferative activity against four human tumor cell lines, including SGC7901, A549, HepG2, and MCF-7. Most of the PPAPs possessed high anti-proliferative activity with IC50 values in the range of 0.89 to 36.98 μM, and significant apoptosis was observed in MCF-7 cells exposed to compounds 2 and 5. Besides, docking results showed that compounds 2 and 5 could strongly combine with the Src homology 2 (SH2) domain of STAT3 via hydrogen bond and hydrophobic interaction, which is one of the key oncogenes and crucial therapeutic targets. Furthermore, compounds 2 and 5 efficiently downregulated the expression of p-STAT3Tyr705 and pivotal effector proteins involved in oncogenic signaling pathways of MCF-7 cells.

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Section: Introductionmentioning

confidence: 99%

Discovery of Novel Polycyclic Polyprenylated Acylphloroglucinols from the Fruits of Garcinia xanthochymus as Antitumor Agents by Suppressing the STAT3 Signaling

Jin

Wang

Gan

et al. 2021

IJMS

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“…Caspase-8, a caspase protein encoded by the Casp8 gene, plays an essential role in cell apoptosis induced by death receptors including the TNF receptors, Fas/Apo1, and DR3 (Varfolomeev et al, 1998). Jin, Shi, Liu, Chen, and Yang (2019) . Therefore, caspase-8 exerts both prodeath and prosurvival effects in different circumstances.…”

Section: Discussionmentioning

confidence: 99%

“…Caspase‐8, a caspase protein encoded by the Casp8 gene, plays an essential role in cell apoptosis induced by death receptors including the TNF receptors, Fas/Apo1, and DR3 (Varfolomeev et al, 1998). Jin, Shi, Liu, Chen, and Yang (2019) showed that a new type of xanthones promoted HepG2 cell apoptosis through enhancing the expression of cleaved caspase‐8, caspase‐9, and caspase‐3. Qiu et al (2019) also found that apigenin inhibited cell proliferation and induced cell apoptosis by activating the caspase‐8 expression.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis

Peng

Liu

Yan

et al. 2020

Journal Cellular Physiology

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Myocardial ischemia/reperfusion (I/R) injury leads to high mortality and morbidity due to the incomplete understanding of the underlying mechanism and the consequent lack of effective therapy. The present study revealed and validated key candidate genes in relation to inflammation and apoptosis pathways underlying myocardial I/R injury. Cathepsin S was identified as the top hub protein based on the protein-protein interaction analysis, and, thus, its role during myocardial I/R injury was further investigated. Myocardial I/R in mice resulted in significantly increased levels of myocardial injury biomarkers (cardiac troponin I, lactic dehydrogenase, and creatinine kinase-MB) and inflammatory cytokines (interleukin-1β [IL-1β], IL-6, and tumor necrosis factor-α), elevated apoptosis rate, and upregulated protein expression of cleaved caspase-8, cleaved caspase-3, and cleaved poly ADP-ribose polymerase. These abovementioned changes were blocked by two different selective cathepsin S inhibitors, LY3000328 or MIV-247. Moreover, Kaplan-Meier survival plot showed that cathepsin S inhibition improved 21-day survival rate following myocardial I/R injury. This study demonstrated that the inhibition of cathepsin S alleviated myocardial I/R-induced injury by suppressing inflammation and apoptosis, which may be used in clinical applications of cardioprotection.

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“…Kandis (Garcinia xanthochymus) secara tradisional digunakan oleh masyarakat untuk penyembuhan luka pasca sunat, membersihkan darah pasca bersalin, dan bengkak. Beberapa senyawa yang terkandung dalam tanaman ini antara lain xanthon, flavonoid, fenolik dan memiliki aktivitas sebagai anti inflamasi (Hamidon et al, 2016) dan senyawa garciniaxanthone mengarah pada pemanfaatannya dalam pengobatan kanker liver (Jin et al, 2019).…”

Section: Jenis-jenis Tumbuhan Berkhasiat Obatunclassified

Traditional Medicinal Plants Used by the Community of Sri Wangi Village, Kapuas Hulu Regency

Yusro

Mariani

2021

JBT

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Kapuas Hulu Regency is a Conservation District because most of its area is protected forest (National Parks and Protected Forests). The existence of people who are close to the forest makes them often interact with plants, one of which is with medicinal plants. This study aimed to analyze the types of medicinal plants used by the community of Sri Wangi Village, Boyan Tanjung District, Kapuas Hulu Regency. This study uses a survey method with data collection techniques by snowball sampling. The data collected is the types of medicinal plants used, the medicinal plants' efficacy, the parts used, processing methods, and administration methods. The results showed that the number of medicinal plants used by the community was 34 species and distributed to 19 families. The highest use is found in the leaves (30%), processed by boiling (43.59%) and used by drinking (43.59%). The data on the types of medicinal plants used by the people of Sri Wangi Village can add to the repertoire of knowledge of medicinal plants in West Kalimantan.

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Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway

Cited by 15 publications

References 33 publications

Discovery of Novel Polycyclic Polyprenylated Acylphloroglucinols from the Fruits of Garcinia xanthochymus as Antitumor Agents by Suppressing the STAT3 Signaling

Discovery of Novel Polycyclic Polyprenylated Acylphloroglucinols from the Fruits of Garcinia xanthochymus as Antitumor Agents by Suppressing the STAT3 Signaling

Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis

Traditional Medicinal Plants Used by the Community of Sri Wangi Village, Kapuas Hulu Regency

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