Two new isoquinoline alkaloids from Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in human glioma cancer U87 cells

Guo, Yaru; Wu, Rui-Ling; Qi, Weiyan; Xu, Hanmei

doi:10.1016/j.fitote.2016.03.004

Cited by 25 publications

(19 citation statements)

References 26 publications

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“…Ma et al (2014) further elucidated the effects of Scolopendra subspinipes on cancer cells, specifically A375 human melanoma cells, finding that the extract could inhibit cell growth at the DNA synthesis phase (S-phase), and induce cell apoptosis. And Ding et al (2016) repeat this finding of cell cycle arrest and apoptosis in their investigation of human glioma (U87) cancer cells with isoquinoline alkaloids 1-2 isolated from Scolopendra subspinipes.…”

Section: Feng (Formulas and Herbs That Extinguish Wind)mentioning

confidence: 67%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

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Section: Feng (Formulas and Herbs That Extinguish Wind)mentioning

confidence: 67%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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“…In this review, we list in Table 2 we found that most compounds exhibited moderate cytotoxicity with IC 50 values ranging from 10 to 50 μM. 22,25,27,33,38,40,45,46,53,68,80,[83][84][85][86][87][88]90,93,98,101,105,159 Three Amaryllidaceae alkaloids, lycorine (321), haemanthamine (326), and haemanthidine 327 Table 2. Higher antiproliferative effects also were reported.…”

Section: Various Isoquinoline Alkaloidsmentioning

confidence: 99%

“…182,183 Through the mitochondria apoptosis pathway, 3,8-diolisoquinoline (1) and 1-methoxy-4,5-diolisoquinoline (2) induced apoptosis in U87 cells with the IC 50 values of 3.46 and 2.14 μM; the Bcl-2/Bax protein ratio also was downregulated. 22 6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (7) had a significant antiproliferative effect on human hepatoma (Huh-7) cells in vitro (EC 50 : 13.97 μM) by inhibiting the action of caspase-8 184 and blocked IL-6/JAK2/STAT3 oncogenic signaling in dimethylhydrazine-induced colorectal carcinoma. 185 Good in vivo anti-neoplastic properties were also found.…”

Section: Various Isoquinoline Alkaloidsmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

133

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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“…5A, the first absorption peak represents the cell during the DNA growth period (G1), the second absorption peak represents the DNA of the cell in the mitosis period (G2/M), and the region between the G1 and G2/M absorption peaks represents the DNA of the cell in the synthesis phase (S) [32]. Ding et al [33] used a flow cytometer to measure human cells and analyzed the cell cycle to evaluate the relationship between the cell cycle and apoptosis. Fig.…”

Section: Cytocompatibility Of Pla and Its Compositesmentioning

confidence: 99%

Modulation, functionality, and cytocompatibility of three-dimensional printing materials made from chitosan-based polysaccharide composites

2016

Materials Science and Engineering: C

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Two new isoquinoline alkaloids from Scolopendra subspinipes mutilans induce cell cycle arrest and apoptosis in human glioma cancer U87 cells

Cited by 25 publications

References 26 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Biologically active isoquinoline alkaloids covering 2014–2018

Modulation, functionality, and cytocompatibility of three-dimensional printing materials made from chitosan-based polysaccharide composites

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