Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Abstract

Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis

“…Then the culture medium was discarded. After that, the cells were cultured with the culture medium containing 0, 0.4, 0.8 and 1.2 mg/mL (11) of S. lyratum polysaccharide, which was marked as the control group, S. lyratum polysaccharide L group, S. lyratum polysaccharide M group, S. lyratum polysaccharide H group. After 24 h of incubation, 10μL CCK-8 was added and incubated for 2 h, and the optical density (OD) was measured by a microplate reader (wavelength 450 nm).…”

Traditional Chinese Medicine is an Alternative Therapeutic Option for Treatment of Pseudomonas aeruginosa Infections

“…On the other hand, deficient immune response results in chronic and persistent bacterial infections (Smith et al, 2009). Immunomodulation is an important function of TCM, which activates or suppresses the immune responses of a variety of immune cells, including macrophages (Jian et al, 2019), dendritic cells (Chen et al, 2006), T cells (Guo et al, 2015), B cells (Kawakita et al, 1987a) and NK cells (Hoffman et al, 2020). The immunomodulatory effects of TCM on host immunity in the context of P. aeruginosa infections have been evaluated in past decade (Table 5) (Kong et al, 2015;Hou et al, 2016;.…”

Osthole Induces Apoptosis and Inhibits Proliferation, Invasion, and Migration of Human Cervical Carcinoma HeLa Cells

“…In the past decades, Chinese medicine therapy has shown remarkable potential as an alternative for cervical cancer treatment or as auxiliary reagents that support cancer treatment owing to their high efficiency and low toxicity [ 4 ]. An increasing number of natural antineoplastic agents were employed in the preclinical and clinical assessments.…”