Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus <i>Paramuricea</i>

Ns, Reddy; Jk, Reed; Re, Longley; Ae, Wright

doi:10.1021/np040147u

Cited by 22 publications

(14 citation statements)

References 9 publications

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“…There are no chemical studies on this species, but from the genus Paramuricea, cytotoxic linderazulenes (Reddy et al, 2005), caffeine (Imre et al, 1987), linderazulene (Imre et al, 1981), and simple indole derivatives in P. chamaeleon (Cimino and De Stefano, 1978) have been isolated.…”

Section: Paramuricea Placomus (Linnaeus 1758)mentioning

confidence: 99%

Chemical and biological aspects of octocorals from the Brazilian coast

Almeida

Moritz

Capel

et al. 2014

Revista Brasileira de Farmacognosia

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Section: Paramuricea Placomus (Linnaeus 1758)mentioning

confidence: 99%

Chemical and biological aspects of octocorals from the Brazilian coast

Almeida

Moritz

Capel

et al. 2014

Revista Brasileira de Farmacognosia

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“…[13] Interestingly, 4 was also obtained as a purple pigment from many marine gorgonians. [12,[14][15][16] Similarly, detailed analysis of the 1D and 2D NMR data as well as comparison of them with the published values led to identification of 5 and 6 as curzerenone [4] and 8,12-epoxy-1(10),4(15),7,11germacratetraen-6-one. [5] Compound 5 was previously identified from several Curcuma species, [6,11,[17][18][19][20][21] whereas 6 was only found in C. zedoaria.…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpenoids from the rhizomes of Curcuma aeruginosa

Boutsada¹,

Giang

Linh

et al. 2018

Vietnam Journal of Chemistry

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Six sesquiterpenoids were isolated from a methanol extract of Curcuma aeruginosa rhizomes by using various chromatographic separations. Their structures were elucidated as pyrocurzerenone (1), dehydrochromolaenin (2), curzeone (3), linderazulene (4), curzerenone (5), and 8,12-epoxy-1(10),4(15),7,11-germacratetraen-6-one (6) by extensive NMR spectroscopic analysis as well as comparison with the reported data. This is the first report of isolation of compounds 1, 2, 4, and 6 from C. aeruginosa.

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“…Linked to their elevated biodiversity and levels of ecosystem functioning, VMEs are growing in recognition as providers of important ecosystem services. Poriferans and cold-water corals, for example, have been shown to provide a strong link between pelagic and benthic foodwebs (Hentschel et al, 2002;Pile and Young, 2006;van Oevelen et al, 2009;Cathalot et al, 2015), and numerous VME-indicator taxa have been associated with the provision of novel biomolecules (Wright et al, 2004;Reddy et al, 2005;Skropeta, 2008;Jobstvogt et al, 2014). The wider biotechnological potential of poriferans in providing new designs for fibre optics, glass, civil engineering and even semiconductors is also starting to be recognised (Hogg et al, 2010).…”

Section: The Value Of Vulnerable Marine Ecosystemsmentioning

confidence: 99%

On the Influence of Vulnerable Marine Ecosystem Habitats on Peracarid Crustacean Assemblages in the Northwest Atlantic Fisheries Organisation Regulatory Area

et al. 2019

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Vulnerable marine ecosystems (VMEs) are considered hotspots of biodiversity and ecosystem functioning in the deep sea, but are also characterised by a high vulnerability to disturbance and a low recovery potential. Since 2006, a series of United Nations General Assembly (UNGA) resolutions have been developed, attempting to ensure the protection of VMEs in international waters. In the Northwest Atlantic Fisheries Organisation (NAFO) Regulatory Area, large areas of seabed have been closed to bottom-contact fishing to protect VMEs. However, knowledge of the influence of VME-indicator taxa on macrofaunal assemblages, and the appropriateness of current fishery closures for protecting macrofaunal biodiversity in this area is limited. Here we investigate relationships between the prevalence of VME-indicator taxa [poriferans (sponges), gorgonian corals, and pennatulaceans (sea pens)] and an extensive suite of peracarid crustacean biodiversity metrics in the NAFO Regulatory Area. We also examine whether the current NAFO VME closures protect areas of significantly elevated peracarid diversity. Of the VME-indicator taxa analysed, poriferans were found to have by far the greatest influence over peracarid assemblages. Assemblage structure was altered, and peracarid abundance, biomass, richness, diversity, and variability were enhanced in areas of elevated poriferan biomass, whilst assemblage evenness was slightly depressed in these areas. These findings reaffirm the perception of poriferans as crucial components of VMEs. In contrast, gorgonian coral density had little influence over the faunal assemblages investigated, perhaps reflecting their relatively low prevalence in the study area. Similarly, pennatulaceans were found to influence peracarid assemblages only weakly. This too may reflect a moderately low density of Pennatulacea in the study area. Our results highlight that the application of taxon distribution model outputs to ecological investigations and management decisions in data-limited environments should be treated with caution. Finally, our results indicate that the current system of fishery closures in the NAFO Regulatory Area may not be optimal in terms of providing adequate protection to VMEs against the impacts of bottom trawling.

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Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea

Cited by 22 publications

References 9 publications

Chemical and biological aspects of octocorals from the Brazilian coast

Chemical and biological aspects of octocorals from the Brazilian coast

Sesquiterpenoids from the rhizomes of Curcuma aeruginosa

On the Influence of Vulnerable Marine Ecosystem Habitats on Peracarid Crustacean Assemblages in the Northwest Atlantic Fisheries Organisation Regulatory Area

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