Chemical and biological aspects of octocorals from the Brazilian coast

Almeida, Maria de Lourdes de; Moritz, Maria Izabel G.; Capel, K. C. C.; Pérez, Carlos Daniel; Schenkel, Eloir P.

doi:10.1016/j.bjp.2014.05.002

Cited by 27 publications

(24 citation statements)

References 154 publications

(188 reference statements)

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“…It appears that prey preference is particularly relevant for the evolution of Tritoniidae + Arminidae as species within this group prey exclusively on Octocorallia. Species within Octocorallia are known for their noxious chemical defenses in addition to the nematocysts present in their tissues [ 99 , 100 ], and these defenses could help explain why a switch to octocorals has occurred rarely within Cladobranchia.…”

Section: Discussionmentioning

confidence: 99%

Prey preference follows phylogeny: evolutionary dietary patterns within the marine gastropod group Cladobranchia (Gastropoda: Heterobranchia: Nudibranchia)

et al. 2017

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BackgroundThe impact of predator-prey interactions on the evolution of many marine invertebrates is poorly understood. Since barriers to genetic exchange are less obvious in the marine realm than in terrestrial or freshwater systems, non-allopatric divergence may play a fundamental role in the generation of biodiversity. In this context, shifts between major prey types could constitute important factors explaining the biodiversity of marine taxa, particularly in groups with highly specialized diets. However, the scarcity of marine specialized consumers for which reliable phylogenies exist hampers attempts to test the role of trophic specialization in evolution. In this study, RNA-Seq data is used to produce a phylogeny of Cladobranchia, a group of marine invertebrates that feed on a diverse array of prey taxa but mostly specialize on cnidarians. The broad range of prey type preferences allegedly present in two major groups within Cladobranchia suggest that prey type shifts are relatively common over evolutionary timescales.ResultsIn the present study, we generated a well-supported phylogeny of the major lineages within Cladobranchia using RNA-Seq data, and used ancestral state reconstruction analyses to better understand the evolution of prey preference. These analyses answered several fundamental questions regarding the evolutionary relationships within Cladobranchia, including support for a clade of species from Arminidae as sister to Tritoniidae (which both preferentially prey on Octocorallia). Ancestral state reconstruction analyses supported a cladobranchian ancestor with a preference for Hydrozoa and show that the few transitions identified only occur from lineages that prey on Hydrozoa to those that feed on other types of prey.ConclusionsThere is strong phylogenetic correlation with prey preference within Cladobranchia, suggesting that prey type specialization within this group has inertia. Shifts between different types of prey have occurred rarely throughout the evolution of Cladobranchia, indicating that this may not have been an important driver of the diversity within this group.Electronic supplementary materialThe online version of this article (10.1186/s12862-017-1066-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Prey preference follows phylogeny: evolutionary dietary patterns within the marine gastropod group Cladobranchia (Gastropoda: Heterobranchia: Nudibranchia)

et al. 2017

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“…Despite the great biodiversity present along the Brazilian coastline, an important source of potential biologically active compounds, chemical analysis and bioprospection screening of Brazilian marine organisms is still incipient (Almeida et al, 2014). To this point, the chemistry of marine natural products in Brazil has been focused on sponges, tunicates and brown algae (Berlinck et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…To this point, the chemistry of marine natural products in Brazil has been focused on sponges, tunicates and brown algae (Berlinck et al, 2004). Concerning the chemical studies on octocorals, from the approximately 107 species reported in Brazil to the present date only twenty have been studied, thirteen of them by Brazilian research groups (Almeida et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Biological activities of marine invertebrates extracts from the northeast brazilian coast

et al. 2020

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Abstract This paper reports the in vitro antiproliferative effects, antiprotozoal, anti-herpes and antimicrobial activities of 32 organic extracts of 14 marine sponges and 14 corals collected in northeast Brazilian coast. The ethanolic extracts of the sponges Amphimedon compressa and Tedania ignis, and the acetone extract of Dysidea sp. showed relevant results concerning the antiproliferative effects against A549, HCT-8, and PC-3 cell lines by sulforhodamine B assay, but also low specificity. Concerning the antiprotozoal screening, the ethanolic extract of Amphimedon compressa and the acetone and ethanolic extracts of Dysidea sp. were the most active against Leishmania amazonensis and Trypanosoma cruzi expressing β-galactosidase in THP-1 cells. In the preliminary anti-HSV-1 (KOS strain) screening, the ethanolic extracts of the sponges Amphimedon compressa, Haliclona sp. and Chondrosia collectrix inhibited viral replication by more than 50%. The most promising anti-herpes results were observed for the ethanolic extract of Haliclona sp. showing high selective indices against HSV-1, KOS and 29R strains (SI> 50 and >79, respectively), and HSV-2, 333 strain (IS>108). The results of the antibacterial screening indicated that only the ethanolic extract of Amphimedon compressa exhibited a weak activity against Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli by the disk diffusion method. In view of these results, the extracts of Amphimedon compressa, Tedania ignis and Dysidea sp. were selected for further studies aiming the isolation and identification of the bioactive compounds with antiproliferative and/or antiprotozoal activities. The relevant anti-herpes activity of the ethanolic extract of Haliclona sp. also deserves special attention, and will be further investigated.

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“…In 2014-2015, several reviews covered general and/or specific areas of marine preclinical pharmacology: (a) Marine pharmacology and marine pharmaceuticals: new marine natural products and relevant biological activities published in 2014 and 2015 [311,312]; marine peptides, bioactivities and applications [313]; bioactive terpenes from marine-derived fungi [314]; bioactive marine natural products from actinobacteria with unique chemical structures [315]; Baltic cyanobacteria as a source of biologically active compounds [316]; biological targets of marine cyanobacteria natural products [317]; marine mussels as a source for bioactive compounds for human health [318]; pharmacological potential of cephalopod ink in drug discovery [319]; pharmacologically active Brazilian octocorals [320]; bioactive natural products isolated from marine microorganisms from Brazil [321]; statistical analysis of marine natural product bioactivity from 1985-2012 [322]; metagenomics and marine natural products drug discovery [323]; new horizons for selected marine natural products as drug leads [324]; marine-sourced agents in clinical and late preclinical development [325]; the global marine pharmaceutical pipeline in 2019: approved compounds and those in Phase I, II, and III of clinical development https://www.midwestern.edu/departments/marinepharmacology.xml. (b) Antimicrobial marine pharmacology: biophysical properties of anti-lipopolysaccharide antimicrobial peptides isolated from marine fish [326]; marine peptides and their anti-microbial activities [327]; marine membrane-active peptides as antimicrobials [328]; marine fungi antibacterial compounds [329].…”

Section: Reviews On Marine Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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Chemical and biological aspects of octocorals from the Brazilian coast

Cited by 27 publications

References 154 publications

Prey preference follows phylogeny: evolutionary dietary patterns within the marine gastropod group Cladobranchia (Gastropoda: Heterobranchia: Nudibranchia)

Prey preference follows phylogeny: evolutionary dietary patterns within the marine gastropod group Cladobranchia (Gastropoda: Heterobranchia: Nudibranchia)

Biological activities of marine invertebrates extracts from the northeast brazilian coast

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

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