Two New Cytotoxic and Virucidal Trisulfated Triterpene Glycosides from the Antarctic Sea Cucumber Staurocucumis liouvillei

Abstract

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 microg/mL.

Cosmeceuticals Properties of Sea Cucumbers: Prospects and Trends

“…Saponins are reported as the major bioactive compound in many effective traditional Chinese and Indian herbal medicines [58]. They play an important role in chemical defence and possess a wide spectrum of pharmacological activities [59][60][61][62][63][64][65][66][67][68]. The majority of sea cucumber saponins, generally known as Holothurins, are usually triterpene glycosides, belonging to the holostane type group rather than non-holostane [62].…”

Vii Foro Iberoamericano De Los Recursos Marinos Y La Acuicultura

“…En estas especies se presentan nuevas saponinas y sapogeninas, glucósidos triterpénicos con grupos sulfatos, todos extraídos a partir de los órganos de Cuvier de estos organismos. Estos compuestos presentan propiedades biológicas como antifúngicos, antitumorales, anti-protozoarios, biocidas en general, y un gran espectro de actividad antiviral no solo a nivel de bioensayo sino ya a nivel de formas farmacéuticas tales como: inyectables, supositorios, y tabletas, específicamente inhibidor de reverso transcriptasa VIH (Silchenko et al,2002;Maier et al, 2001;Miyamoto et al, 1990) con perspectivas reales en el tratamiento contra esta pandemia y también frente al tratamiento de HSV (Maier et al, 2001;Avilov et al, 2000aAvilov et al, , 1998bAvilov et al, , 1997cCollin, 1999;Miyamoto et al, 1992aMiyamoto et al, , 1990bAvilov et al, 1998;Rodriguez et al, 1991;Beutler et al, 1993).…”

The Effects of Sea Cucumber as an Anti-gastritis, Anti-gastric Ulcer, and Anti-Helicobater

“…항바이러스, 항암, 항응고, 항골다공증 등 많은 효능이 보고되 었다 (6)(7)(8)(9)(10)(11)(12) 위염의 억제율 계산 위염을 유발시켰을 때 실험약물에 의한 위염의 억제작용 은 다음과 같이 대조군의 지수 및 면적의 억제율(%)로 inhibition ratio(%)를 나타내었다. Fig.…”