Two new coumarins from Euonymus hamiltonianus

Tantray, Mudasir Ahmad; Shawl, A. S.; Khuroo, Mohammad Akbar; Bhat, Bilal Ahmad

doi:10.1016/j.fitote.2007.11.013

Cited by 7 publications

(5 citation statements)

References 1 publication

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“…Coumarins are rare in Celastraceae species since only four of them have been reported from Gymnosporia senegalensis var. spinosa [39], Euonymus hamiltonianus [40], the Brazilian species, Maytenus guianesis [20], and recently, in Monteverdia communis [41]. The results in the present work are in accordance with those previous reported, since coumarins were only detected in the fruits of Q. ilicina and root bark of E. enantiophyllus.…”

Section: Phytochemical Analysissupporting

confidence: 92%

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Núñez,

Martínez,

Castillo

et al. 2024

Plants

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Chagas disease and leishmaniasis are among the most widespread neglected tropical diseases, and their current therapies have limited efficacy and several toxic side effects. The present study reports the chemical and antikinetoplastid profiles of extracts from five Salvadoran Celastraceae species against theTrypanosoma cruzi epimastigotes stage and Leishmania amazonensis and Leishmania donovani promastigote forms. The phytochemical profile evinced the presence of flavonoids, tannins, sterols, and triterpenes as the main components in all plant species, whereas quinonemethide triterpenoids (QMTs) were restricted to the root bark of the studied species. Antikinetoplastid evaluation highlights the root bark extracts from Zinowewia integerrima, Maytenus segoviarum, and Quetzalia ilicina as the most promising ones, exhibiting higher potency against T. cruzi (IC50 0.71–1.58 µg/mL) and L. amazonensis (IC50 0.38–2.05 µg/mL) than the reference drugs, benznidazole (IC50 1.81 µg/mL) and miltefosine (IC50 2.64 µg/mL), respectively. This potent activity was connected with an excellent selectivity index on the murine macrophage J774A.1 cell line. These findings reinforce the potential of QMTs as antikinetoplastid agents for the development of innovative phytopharmaceuticals and the plant species under study as a source of these promising lead compounds.

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Section: Phytochemical Analysissupporting

confidence: 92%

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Núñez,

Martínez,

Castillo

et al. 2024

Plants

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“…Although 7-methylated and 7-prenylated coumarins and their derivatives are known, this is the first example of a 7-hydroxyethyl coumarin. It could possibly arise from the oxidative degradation of a prenyl group [3,24,25,28]. Coumarins have not been reported previously from the Hyacinthaceae [12].…”

Section: Isolation and Characterization Of Compounds From R Cryptopodusmentioning

confidence: 96%

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis

et al. 2020

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Background: Homoisoflavonoids have been shown to have potent anti-proliferative activities in endothelial cells over other cell types and have demonstrated a strong antiangiogenic potential in vitro and in vivo in animal models of ocular neovascularization. Three species of Rhodocodon (Scilloideaea subfamily of the Asparagaceae family), endemic to Madagascar, R. cryptopodus, R. rotundus and R. cyathiformis, were investigated.Purpose: To isolate and test homoisoflavonoids for their antiangiogenic activity against human retinal microvascular endothelial cells (HRECs), as well as specificity against other ocular cell lines.

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“…Although 7-methylated and 7-prenylated coumarins and their derivatives are known, this is the first example of a 7hydroxyethyl coumarin. It could possibly arise from the oxidative degradation of a prenyl group (El-Sharkawy and Mahmoud, 2016;Tantray et al, 2008;Tesso et al, 2005;Yang et al, 2013). Coumarins have not been reported previously from the Hyacinthaceae (Mulholland et al, 2013).…”

Section: Isolation and Characterization Of Compounds From R Cryptopodusmentioning

confidence: 96%

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus,Rhodocodon rotundus and Rhodocodon cyathiformis

Mas‐Claret

Whitmore

Sishtla

et al. 2019

67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in Cooperat

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Two new coumarins from Euonymus hamiltonianus

Cited by 7 publications

References 1 publication

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus,Rhodocodon rotundus and Rhodocodon cyathiformis

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