Two New Cinnamic Acid Esters from Marine Brown Alga Spatoglossum variabile.

Hayat, Safdar; Atta‐ur‐Rahman, Atta‐ur‐Rahman; Choudhary, Muhammad Iqbal; Khan, Khalid Mohammed; Abbaskhan, Ahmed

doi:10.1002/chin.200307169

Cited by 3 publications

(3 citation statements)

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“…These were in agreement with the findings of Hsu [22] and Onofrejovaa et al [44]. Hayat et al [21] reported that cinnamic acid and some of its esters occur in brown alga Spatoglossum variabile (family: Dictyoaceae). Moreover, our present data show that hydroquinone can be detected only in the studied brown alga species while bromophenol was characteristic for the investigated red seaweeds.…”

Section: -Ii) Effect Of Polyphenolsupporting

confidence: 90%

Anti-mutagenic potential of algal extracts on chromosomal aberrations in Allium cepa L.

Mansour

Mahfouz

Maher

2017

Acta Biologica Hungarica

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In the present study, sodium azide (SA) toxicity and the anti-mutagenic effects of different algal extracts at 0.1% and 0.2% concentrations were studied on the mitotic index (MI), chromosomal and nuclear aberrations using Allium cepa L. root assay. Moreover, phytochemical screening of photosynthetic pigments, antioxidants compounds, total antioxidant, DPPH scavenging activity, polysaccharides, and phenolic contents were done for two red seaweeds (Laurencia obtusa (Hudson) Lamouroux and Polysiphonia morrowii Harvey) and for one brown seaweed (Dictyopteris delicatula Lamouroux). Treatment with 300 μg/ml sodium azide (SA) induced the highest number of aberrations in A. cepa root. A highly significant decrease in the MI appeared after treatment with SA, whereas its value increased following different algal extracts treatments. The highest anti-mutagenic inhibition activity of Dictyopteris delicatula added at 0.2% concentration was 72.96%, 69.84%, 56.89% and 43.59% with the algal polyphenol, polysaccharide, aqueous and methanol extract treatments, respectively. The different algal extracts minimized the genotoxicity and exhibited anti-mutagenic potential against SA in a dose-dependent manner. Phytochemical studies showed that Dictyopteris delicatula contained the highest total phenol, chlorophyll-a and carotenoid quantity. Moreover it exhibited the highest total antioxidant and DPPH scavenging activities. Total polysaccharides and the weight percentage of sulphated polysaccharides were relatively higher in Polysiphonia morrowii followed by Laurencia obtusa. Hydroquinone and bromophenol were detected only in the studied brown and red seaweeds, respectively. Polysiphonia morrowii and Laurencia obtusa contained the highest quantity of galactose, rhmnose and xylose, while Dictyopteris delicatula contained fucose and mannitol as main monosaccharide units. In conclusion, the studied seaweeds may be considered as rich sources of natural antioxidants. Meanwhile the investigated different algal extracts can minimize the genotoxicity in a dose-dependent manner and exhibit anti-mutagenic potential against the mutagenic substance sodium azide.

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Section: -Ii) Effect Of Polyphenolsupporting

confidence: 90%

Anti-mutagenic potential of algal extracts on chromosomal aberrations in Allium cepa L.

Mansour

Mahfouz

Maher

2017

Acta Biologica Hungarica

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“…Dictyotales is the most thoroughly investigated order of brown alga (Konig & Wridgt, 1993) in phytochemical terms, and investigation of the biological activities of marine brown alga belonging to Dictyotales has shown that these exhibit antibacterial, antiviral, and cytotoxic activities (Gerwick et al, 1981). Previously, our group reported new metabolites (cinnamic acid ester and aurone derivatives) from the marine brown alga Spatoglossum variabile (Atta-Ur-Rahman et al, 2001;Hayat et al, 2002). In this study, we now report the hepatoprotective activities in relation to free radical scavenging potential as well as the β-glucuronidase inhibitory effects and cytotoxicity of the cinnamic acid ester derivatives n-butyl 3,5-dimethoxy-4-hydroxycinnamate 1 and isopropyl 3,5-dimethoxy-4-hydroxycinnamate 2 and the aurone derivatives 4′-chloro-2-hydroxyaurone 3 and 4′-chloroaurone 4 from the marine brown alga S. variabile.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotection by chemical constituents of the marine brown algaSpatoglossum variabile: A relation to free radical scavenging potential

Makhmoor¹,

Naheed²,

Shujaat³

et al. 2013

Pharmaceutical Biology

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“…Several novel natural products have been isolated from Spatoglossum variabile and Dictyota dichotoma algae gathered from the coast of the Arabian Sea in Karachi, Pakistan, but their pharmaceutical activity has not yet been investigated. 15,16 An antifungal phenolic compound with aromatic unsaturation was produced from the bacterium Pseudomonas aeruginosa CMG1055, also isolated from the Arabian Sea coast of Pakistan. 17 Gelliodes spp.…”

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Screening for Anti-Cancer Compounds in Marine Organisms in Oman

Dobretsov

Tamimi

Al-Kindi

et al. 2016

SQUMJ

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Objectives: Marine organisms are a rich source of bioactive molecules with potential applications in medicine, biotechnology and industry; however, few bioactive compounds have been isolated from organisms inhabiting the Arabian Gulf and the Gulf of Oman. This study aimed to isolate and screen the anti-cancer activity of compounds and extracts from 40 natural products of marine organisms collected from the Gulf of Oman. Methods: This study was carried out between January 2012 and December 2014 at the Sultan Qaboos University, Muscat, Oman. Fungi, bacteria, sponges, algae, soft corals, tunicates, bryozoans, mangrove tree samples and sea cucumbers were collected from seawater at Marina Bandar Al-Rowdha and Bandar Al-Khayran in Oman. Bacteria and fungi were isolated using a marine broth and organisms were extracted with methanol and ethyl acetate. Compounds were identified from spectroscopic data. The anti-cancer activity of the compounds and extracts was tested in a Michigan Cancer Foundation (MCF)-7 cell line breast adenocarcinoma model. Results: Eight pure compounds and 32 extracts were investigated. Of these, 22.5% showed strong or medium anti-cancer activity, with malformin A, kuanoniamine D, hymenialdisine and gallic acid showing the greatest activity, as well as the soft coral Sarcophyton sp. extract. Treatment of MCF-7 cells at different concentrations of Sarcophyton sp. extracts indicated the induction of concentration-dependent cell death. Ultrastructural analysis highlighted the presence of nuclear fragmentation, membrane protrusion, blebbing and chromatic segregation at the nuclear membrane, which are typical characteristics of cell death by apoptosis induction. Conclusion: Some Omani marine organisms showed high anti-cancer potential. The efficacy, specificity and molecular mechanisms of anti-cancer compounds from Omani marine organisms on various cancer models should be investigated in future in vitro and in vivo studies.

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Two New Cinnamic Acid Esters from Marine Brown Alga Spatoglossum variabile.

Cited by 3 publications

References 1 publication

Anti-mutagenic potential of algal extracts on chromosomal aberrations in Allium cepa L.

Anti-mutagenic potential of algal extracts on chromosomal aberrations in Allium cepa L.

Hepatoprotection by chemical constituents of the marine brown algaSpatoglossum variabile: A relation to free radical scavenging potential

Screening for Anti-Cancer Compounds in Marine Organisms in Oman

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