Hepatoprotection by chemical constituents of the marine brown algaSpatoglossum variabile: A relation to free radical scavenging potential

Histological and biochemical studies on the effect of tetrodotoxin extracted from Puffer fish (Lagocephalus sceleratus) against carbon tetrachloride induced hepatotoxicity in albino mice.

“…The mechanism of the potential protective role of tetrodotoxin in ameliorating the toxic effects of EAC cells is presumably because of its antioxidant and free-radical scavenging properties. Similar results have been obtained from treatment of hepatotoxicity with other natural marine animals such as marine brown alga (Makhmoor et al, 2013), Sepia kobiensis cuttlebone (Ramasamy et al, 2014) and Sea Cucumber Holothuria atra extract (Dakrory et al, 2015). These findings contrast with those of Yamaguchi (1996), who found that liver and kidney sections showed congestion in mice after intraperitoneal injection of tetrodotoxin prepared from the ovary of Takifugu porphyreus.…”

The use of marine-derived bioactive compounds as potential hepatoprotective agents

“…Additionally, another recent study by Makhmoor et al showed the hepatoprotective roles of chemical constituents from the marine brown algae Spatoglossum variabile in animal models with CCl 4 -induced liver disease [35] . The antiradical and hepatoprotective effects of the compounds were tested after analyzing the radical scavenging potential and β-glucuronidase inhibition using in vitro tests.…”

“…The antiradical and hepatoprotective effects of the compounds were tested after analyzing the radical scavenging potential and β-glucuronidase inhibition using in vitro tests. The tested compounds exhibited antiradical activity against 1,1-diphenyl-2-picrylhydrazyl radicals along with superoxide anion scavenging effects [35] . In animal models, the orally pre-administered compounds 2-4 significantly blocked the CCl 4 -induced elevation of serum biochemical markers [35] .…”

“…The tested compounds exhibited antiradical activity against 1,1-diphenyl-2-picrylhydrazyl radicals along with superoxide anion scavenging effects [35] . In animal models, the orally pre-administered compounds 2-4 significantly blocked the CCl 4 -induced elevation of serum biochemical markers [35] . These studies provide basic scientists and clinicians with evidence that novel, bioactive, and antioxidant molecules or compounds isolated from these organisms may assist in the development of novel drugs/means to treat liver diseases.…”