Cancer is a fatal disease where uncontrolled multiplication of cells occurs in the body. Radiation therapy, Chemotherapy, and medications are some of the procedures for treating cancer infections, but they are expensive, and the cure is ineffective. Usage of plants for the treatment of cancer can be one of the effective processes as the phytochemical compounds in these plants have the potential of alleviating various malignancies that includes cancer. The phytochemical compounds found in the plants have the medicinal properties like anti-inflammation, apoptotic, anti-oxidative to treat various disease include the cancer. The following chapter will be about the Indian medicinal plants such as Carica papaya, Glycyrrhiza glabra, Morinda citrifolia, Azadirachta indica, Psidium guajava, and Annona reticulate, in treating the cancer and its future perspectives.