Two New .BETA.-Hydroxychalcones from the Root Bark of Pongamia pinnata.

Tanaka, Toŝhiyuki; Iinuma, Munekazu; Yuki, Kaoru; Fujii, Yuko; Mizuno, Mizuo

doi:10.1248/cpb.39.1473

Cited by 22 publications

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“…Roots are used for cleaning gums, teeth, and ulcers and also effective in gonorrhea [ 12 , 13 ]. Flavones, isoflavones, chalcones, furanoflavonoids and pyranoflavonoids have been reported as the main phenolic constituents from various parts of the investigated plant [ 10 , 14 , 15 , 16 , 17 ]. A furanoflavone, karanjin, isolated from the seeds of this plant possesses insecticidal and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial Properties and Phenolics of Different Solvent Extracts from Bark, Leaves and Seeds of Pongamia pinnata (L.) Pierre

et al. 2012

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This study appraises the antioxidant and antimicrobial attributes of various solvent extracts (absolute methanol, aqueous methanol, absolute ethanol, aqueous ethanol, absolute acetone, aqueous acetone, and deionized water) from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. Maximum extraction yield of antioxidant components from bark (16.31%), leaves (11.42%) and seeds (21.51%) of P. pinnata was obtained using aqueous methanol (20:80). Of the extracts tested, the bark extract, obtained with aqueous methanol, exhibited greater levels of total phenolics [6.94 g GAE/100 g dry weight (DW)], total flavonoids (3.44 g CE/100 g DW), inhibition of linoleic acid peroxidation (69.23%) and DPPH radical scavenging activity (IC50 value, 3.21 μg/mL), followed by leaves and seeds extracts. Bark extract tested against a set of bacterial and fungal strains also revealed the strongest antimicrobial activity with the largest inhibition zone and lowest minimum inhibitory concentration (MIC). HPLC analysis of aqueous methanol extracts from bark, leaves and seeds indicated the presence of protocatechuic, ellagic, ferulic, gallic, gentisic, 4-hydroxybenzoic and 4-hydroxycinnamic acids in bark (1.50–6.70 mg/100 g DW); sorbic, ferulic, gallic, salicylic and p-coumaric acids in leaves (1.18–4.71 mg/100 g DW); vanillic, gallic and tannic acids in seeds (0.52–0.65 mg/100 g DW) as the main phenolic acids. The present investigation concludes that the tested parts of P. pinnata, in particular the bark, have strong potential for the isolation of antioxidant and antimicrobial agents for functional food and pharmaceutical uses.

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Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial Properties and Phenolics of Different Solvent Extracts from Bark, Leaves and Seeds of Pongamia pinnata (L.) Pierre

et al. 2012

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“…The structures were characterized as 7-hydroxy-2'5'-dimethoxy-[6'', 6''-dimethylpyrano(2'', 3'': 4', 3')] chalcone for ponganone-I, and 7-hydroxy-2', 5'dimethoxy-3, 4-methylenedioxy-[6'', 6''-dimethylpyrano (2'',3'',4',3')] chalcone for ponganone II 25 . A new diprenylated chalcone stipulin has been characterized from the roots of Dalbergia stipulacea 26 .…”

Section: Ijpsr (2020) Volume 11 Issue 2 (Review Article)mentioning

confidence: 99%

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2020

IJPSR

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Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, antiinflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent efforts of scientists in a pharmacological screening of chalcones, studying importance of chalcones and their biological activities. INTRODUCTION: Chalcones are a group of phenolic or flavonoid compounds widely distributed in plant kingdom 1. They are both intermediates and end products in flavonoid synthesis, act as defensive compounds, participated in pathogens interactions and contribute to the medicinal value of herbs 2. Naturally occurring chalcones and their synthetic derivatives show a wide spectrum of biological activities 3. For these reasons, chalcones are an object of continuously growing interest amongst scientists 4 .

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“…Antibiotics 2020, 9, x FOR PEER REVIEW 2 of 11 previous studies [8][9][10][11][12], we studied the antimicrobial properties of P. pinnata against several grampositive and gram-negative bacteria. In this preliminary investigation, we found that clinical isolates of pathogenic bacteria, including some MDROs, were susceptible to aqueous extracts of the seed coat of P. pinnata using the agar dilution method.…”

Section: Pulsed-field Gel Electrophoresismentioning

confidence: 99%

“…Pierre, which belongs to the family Leguminosae, is a glabrous, fast-growing tree in coastal and limestone areas of southern Taiwan and other tropical Asian countries [6,7]. Different parts of the P. pinnata tree have been widely used in making remedies for various types of infection [8][9][10] or inflammatory illnesses such as bronchitis and rheumatoid arthritis [11,12]. Based on the findings of previous studies [8][9][10][11][12], we studied the antimicrobial properties of P. pinnata against several gram-positive and gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Different parts of the P. pinnata tree have been widely used in making remedies for various types of infection [8][9][10] or inflammatory illnesses such as bronchitis and rheumatoid arthritis [11,12]. Based on the findings of previous studies [8][9][10][11][12], we studied the antimicrobial properties of P. pinnata against several gram-positive and gram-negative bacteria. In this preliminary investigation, we found that clinical isolates of pathogenic bacteria, including some MDROs, were susceptible to aqueous extracts of the seed coat of P. pinnata using the agar dilution method.…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Synergy of Pongamia pinnata Extract in Combination with Antibiotics for Inhibiting and Killing Methicillin-Resistant Staphylococcus aureus

Tang

et al. 2020

Antibiotics

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Aims: Currently, we face the serious problem of multiple drug-resistant pathogens. The development of new antimicrobial agents is very costly and time-consuming. Therefore, the use of medicinal plants as a source of alternative antibiotics or for enhancing antibiotic effectiveness is important. Methods: The antibacterial effects of aqueous extracts of the seed coat of Pongamia pinnata (Linn.) Pierre in combination with several antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) were tested by broth dilution, checkerboard, and time-kill methods. Results: For the combinations of P. pinnata with ampicillin, meropenem, cefazolin, cefotaxime, cefpirome, and cefuroxime, 70% to 100% were synergistic, with a fractional inhibitory concentration (FIC) index of < 0.5. For the time-kill method with 0.5× minimum inhibitory concentration (MIC) of P. pinnata in combination with 8, 4, 2, and 1 µg mL−1 of the various antibiotics, almost all of the combinations showed synergistic effects, even with the lowest concentrations of P. pinnata, except for aztreonam. No antagonistic effect was observed for these combinations. Conclusions: Based on these findings, aqueous seed coat extracts of P. pinnata have good potential for the design of new antimicrobial agents.

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Two New .BETA.-Hydroxychalcones from the Root Bark of Pongamia pinnata.

Cited by 22 publications

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Antioxidant, Antimicrobial Properties and Phenolics of Different Solvent Extracts from Bark, Leaves and Seeds of Pongamia pinnata (L.) Pierre

Antioxidant, Antimicrobial Properties and Phenolics of Different Solvent Extracts from Bark, Leaves and Seeds of Pongamia pinnata (L.) Pierre

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In Vitro Synergy of Pongamia pinnata Extract in Combination with Antibiotics for Inhibiting and Killing Methicillin-Resistant Staphylococcus aureus

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