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Abstract

Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, antiinflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent efforts of scientists in a pharmacological screening of chalcones, studying importance of chalcones and their biological activities. INTRODUCTION: Chalcones are a group of phenolic or flavonoid compounds widely distributed in plant kingdom 1. They are both intermediates and end products in flavonoid synthesis, act as defensive compounds, participated in pathogens interactions and contribute to the medicinal value of herbs 2. Naturally occurring chalcones and their synthetic derivatives show a wide spectrum of biological activities 3. For these reasons, chalcones are an object of continuously growing interest amongst scientists 4 .

Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products

“…Chalcones (1,3-diphenylprop-2-en-1-ones) are compounds of natural origin serving as starting components for flavonoid biosynthesis in plants [ 113 , 114 ]. Due to the interesting range of biological activities of chalcone derivatives and analogs, the chalcone scaffold is considered to be an important synthetic moiety in medicinal chemistry [ 115 , 116 ].…”

Design, Synthesis, and Molecular Docking of Novel Miscellaneous Chalcones as p38α Mitogen‐Activated Protein Kinase Inhibitors

“…[4] Long ago, plants containing chalcones were utilized in traditional treatments. [5] They proved their efficacy in working as antioxidants [6] and in treating microbial infections, [7] fungal infections, [8,9] viral infections, [10] and inflammations. [11] Besides, recent studies have proven its effectiveness as an anticancer.…”

Synthesis, Characterization, Antimicrobial and Antioxidant Activities of Substituted Pyrazolines From Furyl-Fluorenyl Chalcone

“…The chalcones are produced by the Claisen-Schmidt condensation method [4]. Due to the α, β-unsaturated carbonyl group contained in chalcones [5]. They have a lot of biological activity and can be used as good intermediates as in the synthesis of a number of heterocyclic compounds.…”

“…[6]. The heterocyclic compounds of Isoxazoles [7], 2-Aminopyrimidines [8], Thiazines [9], Oxazines [10], Pyrazoline [11], N-Acyl pyrazoline [12], 2-Amino-3cyanopyridines [13], 3-Cyanopyridines [14], Barbitones [15], 1,4-Diazepine [16], 1,4-Benzothiazepines [17] and Benzo [1,5]thiazepine [18] have been synthesized from chalcones have been synthesized from chalcones. The heterocyclic compound of pyrazoline (fig.…”