Two‐Dimensional Transition Metal Dichalcogenides in Biosystems

Kalantar‐zadeh, Kourosh; Ou, Jian Zhen; Daeneke, Torben; Strano, Michael S.; Pumera, Martin; Gras, Sally L.

doi:10.1002/adfm.201500891

Cited by 326 publications

(259 citation statements)

References 125 publications

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“…Considering that the graphene ink was already commercialized and cheaper than other noble metal-involved electrocatalyst, this electrochemical oxidation treatment shows brightening prospects of graphene ink coatings for sensing application. Moreover, this work demonstrated other 2D material-based inks also could be applied for sensing application [44,45]. In order to verify the practical performance of the proposed method, the GI/GCE was used for determining PA in tablet.…”

Section: Resultsmentioning

confidence: 86%

Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Xie

Zheng

et al. 2018

Electronics

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Graphene ink is a commercialized product in the graphene industry with promising potential application in electronic device design. However, the limitation of the graphene ink is its low electronic performance due to the ink preparation protocol. In this work, we proposed a simple post-treatment of graphene ink coating via electrochemical oxidation. The electronic conductivity of the graphene ink coating was enhanced as expected after the treatment. The proposed electrochemical oxidation treatment also exposes the defects of graphene and triggered an electrocatalytic reaction during the sensing of paracetamol (PA). The overpotential of redox is much lower than conventional PA redox potential, which is favorable for avoiding the interference species. Under optimum conditions, the graphene ink-based electrochemical sensor could linearly detect PA from 10 to 500 micro molar (µM), with a limit of detection of 2.7 µM.

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Section: Resultsmentioning

confidence: 86%

Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Xie

Zheng

et al. 2018

Electronics

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“…For MoS 2 , it is relatively more biocompatible than GO when comparing their in vitro and in vivo toxicity, because MoS 2 is rather inactive to biomolecules. 80,81 Considered together, these findings signified the improved biocompatibility of MoS 2 /GO nanocomposites for potential biomedical applications. Figure 9 Pro-inflammatory responses elicited by diverse materials in J774A.1 cells.…”

Section: Preferential Lung Accumulation Of Mos 2 /Go Nanocompositesmentioning

confidence: 98%

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

et al. 2018

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Selective targeting plus optimal biocompatibility is still a big challenge in nanomedicine. Although many nanomaterials including graphene oxide (GO) and molybdenum disulfide (MoS 2 ) have been tested for this purpose, these materials possess both favorable features and drawbacks, which hampers their further development. Herein, we prepared MoS 2 /GO nanocomposites that manifested excellent dispersity in aqueous solutions and revealed acceptable biocompatibility in vitro and in vivo. Importantly, MoS 2 /GO displayed a novel feature to selectively target the lung. In other words, MoS 2 /GO manifested a pronounced tendency of localization towards the lung comparable to GO, offering a 'guided missile' effect in targeting the lung. Furthermore, MoS 2 /GO composites possessed enhanced drug loading capacity together with reinforced tumor-killing efficacy against cancer cells that have the propensity to metastasize to the lung. Importantly, MoS 2 /GO composites remarkably repressed metastatic tumor growth of B16 murine melanoma cancer cells in lungs of mice. Mechanistically, MoS 2 /GO was demonstrated to reveal compromised reactions towards macrophages at the nano-bio interface relative to GO, which is accountable for the interaction and the uptake of nanosheets by macrophages associated with phagocytosis and macrophagic activation. Considered together, our findings established new MoS 2 /GO nanocomposites with multi-functionalities including selective lung targeting, favorable drug loading capacity, elevated tumor killing efficacy and improved biocompatibility. Our study opens an avenue for MoS 2 /GO nanocomposites in cancer nanotheranostics.

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“…These materials host rich plasmonic physics including an interplay of plasmons with charge density waves [18][19][20] and first plasmon based applications have already been proposed [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Valley plasmonics in transition metal dichalcogenides

et al. 2016

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The rich phenomenology of plasmonic excitations in the dichalcogenides is analyzed as a function of doping. The many-body polarization, the dielectric response function and electron energy loss spectra are calculated using an ab initio based model involving material-realistic Coulomb interactions, band structure and spin-orbit coupling. Focusing on the representative case of MoS2, a plethora of plasmon bands are observed, originating from scattering processes within and between the conduction or valence band valleys. We discuss the resulting square-root and linear collective modes, arising from long-range versus short-range screening of the Coulomb potential. We show that the multi-orbital nature of the bands and spin-orbit coupling strongly affects inter-valley scattering processes by gapping certain two-particle modes at large momentum transfer.

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Two‐Dimensional Transition Metal Dichalcogenides in Biosystems

Cited by 326 publications

References 125 publications

Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility

Valley plasmonics in transition metal dichalcogenides

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