Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Fu, Li; Xie, Kefeng; Zheng, Yuhong; Zhang, Luxi; Su, Weitao

doi:10.3390/electronics7020015

Cited by 44 publications

(7 citation statements)

References 53 publications

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“…The determination of paracetamol by the differential pulse voltammetry in this study is compared with other methods described in literature such as square wave voltammetry (SWV) and cyclic voltammetry (CV) ( Table 2). Although these last two methods offer interesting results with modified electrodes [35]- [45],…”

Section: Comparison With Other Methodsmentioning

confidence: 99%

Electroanalytical Investigation on Paracetamol on Boron-Doped Diamond Electrode by Voltammetry

Martin¹,

Ouattara²

2019

AJAC

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An electroanalytical method was developed for the direct quantitative determination of paracetamol in tablets based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on born-doped diamond (BDD) electrode using two voltammetric techniques (CV and DPV). The electrochemical measurements performed by cyclic voltammetric (CV) and differential pulse voltammetry (DPV) techniques were carried out using a cathodically pretreated boron-doped diamond electrode in HClO 4 and KClO 4 electrolytes. HClO 4 was then selected for analytical purposes and scan rate studies were also completed. The oxidation of the paracetamol is found to be irreversible and a diffusion-controlled nature of the paracetamol oxidation peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 0 µM to 13.87 µM, with 0.16 µM and 0.55 µM as the detection and quantification limit respectively.

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Section: Comparison With Other Methodsmentioning

confidence: 99%

Electroanalytical Investigation on Paracetamol on Boron-Doped Diamond Electrode by Voltammetry

Martin¹,

Ouattara²

2019

AJAC

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“…However, most QDs lack biocompatibility due to their intrinsic cytotoxicity [14,15]. In recent years, the use of graphene quantum dots (GQDs) has spread in life sciences applications [16][17][18]. GQDs are two-dimensional materials based on graphene; they are structured as a single-atom-thick sheet of honeycomb-arranged, sp2-bonded carbon atoms and they have great electronic properties [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

et al. 2020

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Glioblastoma is the most aggressive and lethal brain cancer. Current treatments involve surgical resection, radiotherapy and chemotherapy. However, the life expectancy of patients with this disease remains short and chemotherapy leads to severe adverse effects. Furthermore, the presence of the blood–brain barrier (BBB) makes it difficult for drugs to effectively reach the brain. A promising strategy lies in the use of graphene quantum dots (GQDs), which are light-responsive graphene nanoparticles that have shown the capability of crossing the BBB. Here we investigate the effect of GQDs on U87 human glioblastoma cells and primary cortical neurons. Non-functionalized GQDs (NF-GQDs) demonstrated high biocompatibility, while dimethylformamide-functionalized GQDs (DMF-GQDs) showed a toxic effect on both cell lines. The combination of GQDs and the chemotherapeutic agent doxorubicin (Dox) was tested. GQDs exerted a synergistic increase in the efficacy of chemotherapy treatment, specifically on U87 cells. The mechanism underlying this synergy was investigated, and it was found that GQDs can alter membrane permeability in a manner dependent on the surface chemistry, facilitating the uptake of Dox inside U87 cells, but not on cortical neurons. Therefore, experimental evidence indicates that GQDs could be used in a combined therapy against brain cancer, strongly increasing the efficacy of chemotherapy and, at the same time, reducing its dose requirement along with its side effects, thereby improving the life quality of patients.

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“…Therefore, the selection of the solvent in extraction processes has a significant impact on the efficacy of the extraction. The target should be highly soluble in the selected solvent, while other non-target components should be slightly or insoluble in the extraction solvent [57][58][59][60][61][62]. Because polyphenols have a polyphenol hydroxyl group, making them somewhat polar, they can be extracted by hydrophilic solvents such as water, ethanol, methanol and acetone.…”

Section: Extraction Of Plant Polyphenolmentioning

confidence: 99%

Extraction and Electrochemical Analysis of Polyphenols in Plant Samples

Zhou¹

2019

International Journal of Electrochemical Science

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Plant polyphenols are polyphenolic secondary metabolites that widely exists in plants and are mainly found in the skin, root, leaf and fruit. Plant polyphenols are natural antioxidants and are the most powerful free radical scavengers known. Therefore, the extraction and analysis of these polyphenols has attracted considerable attention. In this review, the extraction of plant polyphenols is discussed. Then, we focus on methods for the analysis and determination of plant polyphenols with a specific focus on analysis and detection methods based on electrochemical sensing.

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Graphene Ink Film Based Electrochemical Detector for Paracetamol Analysis

Cited by 44 publications

References 53 publications

Electroanalytical Investigation on Paracetamol on Boron-Doped Diamond Electrode by Voltammetry

Electroanalytical Investigation on Paracetamol on Boron-Doped Diamond Electrode by Voltammetry

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

Extraction and Electrochemical Analysis of Polyphenols in Plant Samples

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